HEMATOLOGIC MALIGNANCY

This study looks at whether a special process can safely remove the 'allergy' label for certain penicillin-type antibiotics in people with blood cancers like leukemia or lymphoma. About 3,800 hospitalized patients with a reported beta-lactam allergy will take part. The goal is to…

This study tests whether combining two drugs, pirtobrutinib and venetoclax, can help control mantle cell lymphoma (MCL) that has returned or not responded to prior therapy. About 30 adults with confirmed MCL will take both pills by mouth. The goal is to see how many patients' tum…

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil alongside their usual GVHD prevention medicine…

This study is for people who have had a stem cell transplant for blood cancer and are at high risk of serious fungal infections. The standard preventive drug may not work well enough anymore, so researchers are testing a stronger drug called posaconazole. They will check the drug…

This study tests a new way to prepare stem cells for transplant in children and adults with blood cancers like leukemia. The method removes certain immune cells to lower the risk of graft-versus-host disease, a serious side effect. About 70 participants will receive the treatment…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study compares different durations of maribavir treatment in 218 adults who have a stubborn CMV infection after a stem cell transplant. The goal is to see which treatment length best prevents the infection from coming back. Participants must be at least 18 and have had their…

This study tests a less intense stem cell transplant for people with blood cancers like leukemia or lymphoma. The treatment uses chemotherapy and radiation before receiving donor stem cells from a partially matched family member. The goal is to help the body accept the new cells …

This early-phase study tests a new way to give immune cells (T-cells) after a stem cell transplant for children with high-risk blood cancers. The goal is to see if giving special memory T-cells early can help fight cancer while reducing dangerous side effects like graft-versus-ho…

This early-stage study tests the safety of a new drug called ziftomenib when combined with standard chemotherapy for people whose acute myeloid leukemia (AML) has returned or not responded to treatment. The study includes adults with specific genetic changes (NPM1 mutation or KMT…

This study tests whether injecting specially grown immune cells (HTLPs) after a cord blood transplant can help adult blood cancer patients rebuild their immune system faster. The goal is to reduce the risk of serious infections and graft-versus-host disease. Ten participants will…

This study is for children and young adults up to age 21 with a high-risk type of leukemia (CD19+ ALL) that has come back or not responded to treatment. Researchers are testing a new way to do a stem cell transplant using cells from a partially matched family member, followed by …

This study tests two different chemotherapy conditioning plans combined with a single drug (cyclophosphamide and methotrexate) to prevent graft-versus-host disease (GVHD) after a stem cell transplant. About 82 adults with blood cancer who have a matched donor will participate. Th…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This early study tests whether adding the drug abatacept to standard anti-rejection medicines can safely prevent graft-versus-host disease (GVHD) in 10 adults with blood cancers receiving a special stem cell transplant called omidubicel. Participants will receive chemotherapy bef…

This early-phase study is testing whether it is safe and possible to collect a patient's own stem cells and give them together with CAR T-cell therapy for blood cancers that have come back or not responded to treatment. About 20 adults aged 18 to 85 with certain types of lymphoma…

This early-stage trial tests whether adding decitabine and venetoclax to a standard stem cell transplant is safe for people with high-risk blood cancers like leukemia. About 20 adults aged 18-75 with a matching donor will take part. The goal is to find the best dose that limits s…

This study looks at whether offering blood transfusions at home for people with advanced blood cancers who are in hospice care can improve their quality of life and mood. About 700 adults with relapsed or hard-to-treat blood cancers will take part. The goal is to see if this prog…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can help adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to either get PEACE plus standard …

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients receiving stem cell transplants. The program is designed to improve quality of life during a difficult treatment. Researchers will enroll 40 adults to see if the progra…

This study is testing whether using a virtual reality headset during a bone marrow biopsy can help lower pain and anxiety. About 160 adults with blood cancers will be randomly assigned to use the headset or receive standard care. The goal is to see if this simple, drug-free appro…

This study tests if a 12-week program combining a special diet supplement with online brain exercises can improve memory and thinking in blood cancer survivors. About 80 adults who have mild to moderate thinking problems after treatment will be randomly assigned to either start t…

This study looks at whether a 12-week home exercise program with remote coaching and monitoring can improve heart and lung fitness and daily activity levels in people who have finished treatment for lymphoma. About 80 participants will be randomly assigned to either home-based or…

This study is testing whether giving blood transfusions at home is practical and acceptable for cancer patients who need regular transfusions. About 30 adults with blood cancers or bone marrow disorders will receive 1-5 blood units at home. Researchers will track how often transf…

This study tests a program called Nite2Day+ that uses mindfulness and sleep tips to help blood cancer patients with sleep problems, fatigue, stress, and pain. About 60 adults with certain blood cancers will either get the program or standard care. The program includes a mobile ap…

This study tests a special support program (BMT-CARE) for people caring for a loved one undergoing a bone marrow transplant. The goal is to see if the program improves the caregiver's quality of life compared to standard care. The study will enroll 800 caregivers and track their …

This study compares two oral medications—diosmin-hesperidin (a plant-based supplement) and loratadine (an allergy drug)—to prevent severe bone pain caused by G-CSF, a medicine that boosts white blood cells in people with blood cancers. About 88 adults receiving G-CSF for leukemia…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will use ultrasound to check the heart function of 60 patients before and within a few days after treatment. The goal is to find out how often the…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk about stem cell transplant and cellular therapy decisions. About 60 youth and their parents will try the tool, and researchers will measure if it is…

This study follows 100 children and young adults who have received CAR T-cell therapy to learn about short- and long-term side effects. Researchers will track how often patients get infections, have delays in blood cell recovery, or experience nerve damage. The goal is to better …

This study looks at how energy use inside cancer and immune cells influences treatment success in blood cancers like leukemia. Researchers will analyze samples from 350 patients and healthy donors to find patterns linked to therapy resistance. The goal is to better understand the…

This study looks at blood samples from 50 people with blood cancers who are receiving CAR T therapy. Researchers want to understand why the cancer sometimes comes back or doesn't respond to treatment. They will measure immune cells and genetic changes over time to find patterns l…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how their immune system responds to the vaccine and how long that protection lasts. Up to 150 children will take part at St. Jude Children's Research Hospital. The goal …

This study collects bone marrow samples from 70 people with blood cancer to grow 3D organoids—tiny lab-made models of the cancer. Researchers will test different chemotherapy combinations on these organoids to see which kills the most cancer cells. The goal is to learn if this ap…

This study is for people with cancer who are about to start or have already received FDA-approved immunotherapy. Researchers want to see if special blood tests (immune-methylation and cytokine profiling) can predict whether the treatment will work. The goal is to better understan…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…

This study enrolls 88 adults receiving a stem cell transplant for blood cancers. Researchers collect DNA from blood, skin, hair, and cheek cells before and after transplant to see which source gives the most reliable genetic information for adjusting drug doses. The goal is to im…