New drug cocktail aims to beat deadly fungus in blood cancer patients

NCT ID NCT07185503

Recruiting now Disease control Sponsor: Institute of Hematology & Blood Diseases Hospital, China Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a combination of two antifungal drugs—liposomal amphotericin B plus either posaconazole or isavuconazole—in 60 adults with blood cancers who also have a serious fungal infection called mucormycosis. The goal is to see if the combo can clear the infection better and with fewer side effects than standard treatments. Participants will be closely monitored for symptom improvement, side effects, and survival over several months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liposomal amphotericin B combined with posaconazole or isavuconazole
What this could lead to: If this works, it could offer a more effective and safer treatment option for a deadly fungal infection in people with blood cancers.
What could go wrong: This is a small, early-phase study with only 60 participants and no comparison group. The combination may still cause serious side effects or fail to improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Zygomycosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUCORMYCOSIS IN HEMATOLOGIC MALIGNANCIES

Contacts and locations

Locations

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
RECRUITING

Tianjin, China
Second Hospital of Tianjin Medical University
NOT_YET_RECRUITING

Tianjin, China
Shengjing Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, China
The First Affiliated Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, China
The First Affiliated Hospital of Harbin Medical University
NOT_YET_RECRUITING

Harbin, China
The Second Hospital of Dalian Medical University
NOT_YET_RECRUITING

Dalian, China
Tianjin First Central Hospital
NOT_YET_RECRUITING

Tianjin, 300020, China
Tianjin Haihe Hospital
NOT_YET_RECRUITING

Tianjin, China
Tianjin Union Medical Center of Nankai University
NOT_YET_RECRUITING

Tianjin, China

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