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Frailty check may steer safer cancer care for seniors

NCT ID NCT03680677

Recruiting now Knowledge-focused Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study looks at whether simple frailty assessments can predict how older patients (60+) with acute leukemia or MDS will fare after intensive treatments like chemotherapy, CAR T-cell therapy, or stem cell transplants. Researchers will track frailty status and compare outcomes like non-relapse mortality across frail, pre-frail, and non-frail patients. The goal is to see if frailty measures can help personalize treatment intensity to improve survival and reduce harm.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Frailty phenotype assessments
What this could lead to
If frailty assessments prove reliable, they could help doctors tailor cancer treatments to each older patient's resilience, potentially improving survival and quality of life.
What could go wrong
This is a small, early-stage study, so results may not apply broadly. Frailty measures may not fully predict treatment outcomes, and the study does not test a new treatment itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute leukemia hematopoietic and lymphoid cell neoplasm leukemia myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, ACUTE MDS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Abramson Cancer Center of the University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

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