When to boost? new trial seeks best COVID-19 shot timing for vulnerable patients

NCT ID NCT05415267

Recruiting now Knowledge-focused Sponsor: Kirby Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Participants will also receive a diphtheria/tetanus booster to compare how the immune system responds to different vaccines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: COVID-19 booster vaccine and diphtheria/tetanus toxoids vaccine
What this could lead to: If successful, this could help doctors choose the best time to give COVID-19 boosters to people starting immunosuppressive therapy, improving their protection against severe illness.
What could go wrong: This is a Phase 3 trial, but it focuses on timing rather than a new treatment. Results may not apply to all types of immunosuppression or vaccines, and individual responses may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AUTOIMMUNE DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

autoimmune disease hematopoietic and lymphoid cell neoplasm inflammatory disease COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Locations

Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
Concord General Repatriation Hospital
RECRUITING

Concord, New South Wales, 2137, Australia
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
St Vincent's Hospital, Sydney
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.