COVID-19

This early-stage study tests a new booster vaccine for COVID-19 made from a harmless sheep virus. It aims to see if the vaccine is safe and boosts immunity in 96 healthy adults aged 18 to 55 who have already been vaccinated or infected. Participants receive one shot and are monit…

This study tests two ways to increase COVID-19 vaccination among Latino adults and their friends in Maryland. One group learns motivational interviewing skills to encourage their peers, while the other just gets vaccine information. Researchers will compare how many friends get v…

This study is testing an updated mRNA COVID-19 vaccine (mRNA-1283) designed to protect against newer variants of the virus. Researchers want to see how well the vaccine boosts the immune system and if it is safe. The study involves 832 adults, including those 65 and older or with…

This early-stage trial tests a new nasal spray vaccine called COV2 against COVID-19. About 20 healthy adults who have already received at least two COVID-19 shots will get two doses of the nasal vaccine, 28 days apart. The study checks if the vaccine is safe and how well it boost…

This early-stage study tests a new booster vaccine called OCU500, designed to protect against COVID-19. Unlike a shot, it is given as a nasal spray or inhaler. The study involves 80 healthy adults aged 18-64 who have already received a primary COVID-19 vaccine series and at least…

This study looks at the best way to give COVID-19 booster and flu shots to people with weakened immune systems (like those with rheumatoid arthritis, organ transplants, or HIV). It will compare getting both vaccines on the same day versus one month apart, and also test if getting…

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot in the arm or as a nasal spray, and researchers will check for side effects and measure immune respo…

This study tests two experimental COVID-19 booster vaccines in 80 healthy adults aged 40-64. The vaccines are designed to create stronger and longer-lasting immune responses. Participants will receive one dose of either a vaccine or a placebo and will be monitored for side effect…

This study tests a new nasal spray COVID-19 vaccine (NDV-HXP-S-KP.2) against a standard mRNA shot in 200 adults who have already been vaccinated. The goal is to see if the nasal vaccine is safe and tolerable. Participants must be 18-64 with a high-risk condition or 65+ and have h…

This study tests whether giving the antiviral drug remdesivir for 10 days can prevent severe COVID-19 in kidney transplant patients who have mild or no symptoms. The goal is to safely allow transplants to happen sooner, reducing time on dialysis. The trial involves 15 adults rece…

This study tests whether baricitinib, an anti-inflammatory drug, can improve thinking, physical function, and quality of life in people with long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This study tests different COVID-19 treatments in adults with mild symptoms to see which ones clear the virus fastest. Participants are healthy adults aged 18-60 with a positive test and early symptoms. The goal is to compare drugs like antivirals and antibodies against no treatm…

This study is checking if people who already take antihistamines (allergy meds) or amantadine (a Parkinson's drug) have milder COVID-19 infections. Researchers will track hospitalizations, survival, and long COVID symptoms in up to 140,660 patients. The goal is to see if these co…

This study looks at whether combining two antiviral drugs or taking them for a longer time helps people with weakened immune systems clear COVID-19 faster. About 256 participants with mild to moderate COVID-19 will be randomly assigned to different treatment plans. The goal is to…

This study tests whether combining two antiviral drugs (remdesivir and nirmatrelvir/ritonavir) or taking the standard drug for a longer time (10 days instead of 5) helps immunocompromised people with mild COVID-19 clear the virus faster. About 256 adults with weakened immune syst…

This study checks if a new COVID-19 test, called the Metrix COVID Test, works well when used at home or in clinics. About 1,000 people with COVID-like symptoms will take the test, and their results will be compared to a standard FDA-cleared test. The goal is to see if the new tes…

This study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a PET-MR scan. Researchers want to see if it can safely and accurately find clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 healthy volunteers …

This study is testing a breathalyzer kiosk that can detect COVID-19, flu, and RSV from a person's breath. About 100 adults, both with and without symptoms, will breathe into the device. The goal is to see if the kiosk can accurately identify infections compared to standard nasal …

This early-stage study tests an experimental antibody called MDX2301 in 80 healthy adults and those at higher risk for severe COVID-19. Participants receive either the antibody or a placebo by injection or IV. The main goal is to check safety and how the body processes the drug.

This study tests whether an oral drug called Mitoquinone can prevent COVID-19 in adults who have had high-risk exposure to someone with confirmed SARS-CoV-2 infection. Participants will be randomly assigned to receive the drug or a placebo. The goal is to see if the drug can stop…

This study aims to reduce COVID-19 illness and death among people who live and work in prisons. Researchers will test different ways to encourage vaccine uptake in Pennsylvania prisons, involving over 37,000 participants. The goal is to find simple, effective methods to increase …

This small study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce fatigue and other lingering symptoms of post-COVID syndrome. Researchers will enroll 40 adults diagnosed with post-COVID condition who have had symptoms like chron…

This study tests a new inhaled medication called Optate for people with mild COVID-19. About 40 adults will receive either Optate or a placebo spray. Researchers will measure virus levels in the nose and track symptom changes using a quality-of-life survey.

This study tests a small device worn on the ear that sends gentle electrical pulses to nerves. The goal is to see if it can reduce pain and other symptoms in children ages 11-18 who have had a concussion or long COVID for at least 3 months. The study will measure changes in balan…

This study is testing four different seawater nasal sprays to see how well they work for nasal symptoms like congestion, runny nose, and sneezing. It includes over 1,000 people of all ages, including pregnant women, with conditions like colds, allergies, or sinus infections. The …

This study is testing whether giving arginine, a natural protein, can help children aged 3 to 21 who are in the hospital with COVID-19. Researchers want to see if arginine improves how the body's cells produce energy. Participants will receive one of three doses of arginine three…

This study tests whether a structured 8-week program of physical and cognitive exercises can improve daily function, thinking skills, and quality of life in adults with Long COVID and chronic conditions like high blood pressure or diabetes. About 374 participants will be randomly…

This study tests whether Astepro nasal spray, usually used for allergies, can help manage early COVID-19 symptoms and lower the amount of virus in the body. About 280 adults with a positive COVID-19 test will use the spray or a placebo for 10 days. Researchers will track symptoms…

This study tests whether adding music to guided mindfulness meditation helps people of African descent manage stress, anxiety, and depression better than meditation alone. About 70 adults with anxiety or depression will join virtual sessions. The goal is to see if a culturally re…

This study tests whether a gentle ultrasound pulse to a specific brain area can improve thinking problems in people with long COVID brain fog. Researchers will compare active ultrasound to a sham (fake) treatment in 40 adults who have had brain fog for at least 4 weeks after COVI…

This early-stage study tests a new drug called ratutrelvir in 90 adults with mild to moderate COVID-19 who are not in the hospital. Participants take the study drug plus standard care to see if it helps them recover faster and is safe. The goal is to find the best dose for future…

This study looks at how common COVID-19 is among healthcare workers by testing for antibodies. It also checks their mental and emotional well-being during the pandemic. The goal is to learn how to better support healthcare workers and prepare for future outbreaks.

This study looks at how COVID-19 changes the bacteria in your gut and whether that leads to long COVID symptoms like fatigue, brain fog, and stomach issues. Researchers will collect stool and blood samples from 400 people—half with long COVID and half without—to find differences …

This study is creating a large registry of up to 10,000 adults hospitalized with COVID-19 across many countries. Researchers will track serious outcomes like death, heart failure, and kidney problems to better understand the disease. The goal is to gather knowledge to help preven…

This study collects blood, nose, and saliva samples from 20,000 people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The samples are stored for future research to better understand these infections and how the body fights them. Participation last…

This study looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, blood pressure, and mental stress. Researchers at Indiana University will track 100 healthy adults aged 18-75 using wearable devices, fitness tests, and blood samples. The goal is to…

This study tests whether placing a clear plastic box over a patient's head during CPR helps reduce the spread of viruses to healthcare workers. Researchers will measure how well the box works during chest compressions and breathing procedures. The goal is to make emergency care s…

This study uses surveys and interviews to learn how COVID-19 impacts the health and daily life of adults with cancer. Researchers will track how many people take part over 12 months. The goal is to gather information, not to test a treatment.

This study is looking at how well antibodies in the blood and nose can fight COVID-19 and monkeypox over time. Researchers will study 30 adults who have received vaccines or antibody treatments for these viruses. The goal is to better understand how long protection lasts, not to …

This study follows 1800 healthcare workers from 8 countries to learn how COVID-19 infection and vaccination affect their immune systems. Researchers will collect blood samples and health data to see how different virus variants may escape natural or vaccine-induced protection. Th…

This study looks at whether community health workers can use personal stories on social media to share reliable information about flu, COVID-19, and other respiratory viruses. About 1,400 health workers will be trained in science communication and then post on social media. Resea…

This study follows 345 adults to see how often COVID-19 leads to long-term lung, heart, or kidney problems. Researchers compare people who had COVID-19 with those who never got it. The goal is to find better ways to predict and prevent these complications.

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu, COVID-19, or other respiratory viruses raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to pr…

This study follows 2300 adults who have recovered from COVID-19 to learn how many develop long-term symptoms (like fatigue or organ damage) and why. Researchers will look at medical records and track participants over time. No new treatments are tested—the goal is simply to gathe…

This study aims to collect samples and health information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to learn how viruses behave differently in healthy individuals versus those with weakened immune sy…

This study aims to understand how respiratory viruses like COVID-19, flu, and RSV spread in communities. Researchers will track infections in 25,000 people of all ages through testing and surveys. The goal is to improve public health responses and preparedness for future outbreak…

This study looks at how COVID-19 immunity changes over time in households in Hong Kong. Researchers will measure antibodies from vaccines and past infections in about 1,350 people. The goal is to understand how protection against the virus shifts at the family level.

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood with the new tablet compared to the original, and whether taking it with food or as a drink changes…

This study aims to understand how the immune system changes over a year after getting the flu and/or COVID-19 vaccine. Researchers will follow 150 NIH staff members aged 18 and older, collecting blood and nasal samples monthly. No vaccines are given as part of the study; particip…

This study uses an online survey to identify health risks, especially those related to medication use, in 2,000 adults aged 18 and older. Researchers will look at patterns of self-medication, supplement use, polypharmacy (taking 5+ drugs), and serious drug interactions. The goal …

This study follows 800 people who have recovered from COVID-19 to see how long the virus lingers in different body fluids like nose swabs, stool, semen, and breast milk. Researchers also track antibody development and long-term symptoms. The goal is to better understand recovery …

This study looks at whether screening for social needs (like food or housing) and referring people to community services can help prevent COVID-19 and reduce its long-term health effects. About 1,500 adults from emergency departments and COVID-19 testing sites will take part. Res…

This study looks at 320 adults who need strong immune-suppressing drugs and have already had at least two COVID-19 vaccines. Researchers want to know if giving a booster right before starting treatment or waiting six months provides better protection. The goal is to find the safe…

This study aims to understand why the protection from COVID-19 vaccines fades over time. Healthy adults aged 18 and older who are scheduled to receive a new vaccine or booster for COVID-19 or another emerging infection can join. Participants will give blood samples and health upd…

This study compares how well two FDA-approved COVID-19 vaccines (Novavax and Pfizer-BioNTech) and flu vaccines work in adults aged 18-79 who have health risks like asthma, heart disease, or depression. Researchers will measure immune responses and side effects over time. The goal…

This study looks at how pregnant and non-pregnant patients recover after being in the intensive care unit (ICU) for COVID-19 and lung failure. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to better…

This study uses cardiac MRI to examine heart and lung damage in 510 COVID-19 survivors who had severe symptoms. Researchers aim to link imaging findings with ongoing symptoms like shortness of breath and fatigue. The goal is to better understand why some people have lasting probl…

This study tests a virtual, community-based program that combines music and mindfulness to help People of African Descent manage stress, anxiety, and depression during COVID-19. About 48 participants aged 16 and older will join online sessions. Researchers will measure brain acti…

This study tests whether a diet rich in fermented foods (like yogurt, kimchi, and sauerkraut) is tolerable and can improve quality of life for people who survived a critical illness, including severe COVID-19. Researchers will look at gut health, inflammation, and mental and musc…