COVID-19

This early-stage trial tests two versions of a nasal spray vaccine called COV2, designed to protect against COVID-19. About 20 healthy adults who have already had at least two COVID-19 shots will receive two doses of the nasal vaccine. The study checks for side effects and measur…

This study tests two new COVID-19 booster vaccines in 80 healthy adults aged 40-64. One vaccine includes a special ingredient called 's3' designed to boost the body's immune response. Researchers will check safety and measure how well the vaccines work against the virus.

This study tests updated mRNA COVID-19 vaccines designed to target current virus variants. About 832 adults, especially those 65+ or with risk factors, will receive the vaccine to measure immune response and safety. The goal is to ensure the vaccine remains effective as the virus…

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot in the arm or as a nasal spray, with some shot versions including an adjuvant to boost the immune re…

This early-stage study tests a new type of COVID-19 booster vaccine made from a harmless sheep virus. It aims to see if it is safe and boosts the immune system in healthy adults aged 18 to 55 who have already been vaccinated or infected. The study will enroll 96 people and look f…

This study aims to find the best way to encourage more Latino adults and their friends to get the COVID-19 vaccine. Researchers will compare two methods: teaching some people motivational interviewing skills versus simply providing vaccine information. The goal is to see which ap…

This early-stage study tests a new booster vaccine called OCU500, designed to protect against COVID-19. Unlike a shot, it is given as a nasal spray or inhaler. The study involves 80 healthy adults aged 18-64 who have already received a primary COVID-19 vaccine series and at least…

This study looks at the best way to give COVID-19 booster and flu shots to people with weakened immune systems (like those with rheumatoid arthritis, organ transplants, or HIV). It will compare getting both vaccines on the same day versus one month apart, and also test if getting…

This study tests a new nasal spray COVID-19 vaccine (NDV-HXP-S-KP.2) against a standard mRNA shot in 200 adults who have already been vaccinated. The goal is to see if the nasal vaccine is safe and tolerable. Participants must be 18-64 with a high-risk condition or 65+ and have h…

This study looks at whether using two antiviral drugs together (remdesivir plus nirmatrelvir/r) works better than one drug alone for treating COVID-19 in people with weakened immune systems. It also tests if taking the medication for 10 days instead of 5 helps clear the virus fas…

This study looks at whether giving a combination of two antiviral drugs or a longer treatment course can help people with weakened immune systems clear COVID-19 faster. About 256 participants with mild or no symptoms will receive either standard treatment or an enhanced approach.…

This study looks at whether people who already take antihistamines (for allergies) or amantadine (for Parkinson's) have milder COVID-19. Researchers will track over 140,000 patients to see if these drugs lower hospital admissions and improve survival. The goal is to find a simple…

This study tests whether a 10-day course of the antiviral drug remdesivir can prevent severe COVID-19 in kidney transplant recipients who have mild or no symptoms. About 15 adults with end-stage kidney disease who test positive for SARS-CoV-2 will receive remdesivir starting just…

This study tests whether giving arginine, a natural protein, can improve energy production in cells of children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses of arginine three times a day for up to five days. Researchers will measure chang…

This study tests whether baricitinib, an anti-inflammatory drug, can improve thinking, physical function, and quality of life in people with long COVID. About 550 adults who had COVID-19 at least 6 months ago will receive either baricitinib or a placebo for 6 months. The main goa…

This study is testing a breathalyzer kiosk that can detect COVID-19, flu, and RSV by analyzing a person's breath. About 100 adults, both with and without symptoms, will breathe into the device for 8 seconds. The goal is to see if the breathalyzer is as accurate as the standard no…

This early-phase study tests a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 participant…

This study checks if a new COVID-19 test, called Metrix COVID Test, works well when used at home or in clinics. About 1000 people with COVID-like symptoms will take the test, and results will be compared to a standard FDA-cleared test. The goal is to see if the new test accuratel…

This study tests a new drug called MDX2301 to see if it can prevent COVID-19 in healthy adults and those at higher risk for severe illness. About 80 participants will receive either the drug or a placebo by injection or IV. The main goal is to check safety and how the body respon…

This study tests a new drug called VYD2311, a monoclonal antibody that blocks the COVID-19 virus from entering cells. About 1,770 adults and teens aged 12 and older will receive either VYD2311 or a placebo as a monthly shot for 3 months. The goal is to see if it safely prevents C…

This study aims to reduce COVID-19 illness and death among people who live or work in prisons. Researchers will test different ways to encourage vaccine uptake, such as community engagement, in Pennsylvania prisons. Over 37,000 incarcerated individuals and staff will take part, a…

This study tests whether an oral medication called Mito-MES can prevent COVID-19 in healthy adults who have been in close contact with someone who has the virus. Participants will take either the study drug or a placebo for a short time. The goal is to see if the drug can stop th…

This study tests whether adding music to guided mindfulness meditation helps reduce stress and anxiety better than meditation alone. It involves 70 adults of African descent who have symptoms of anxiety or depression. Participants will join virtual sessions and report their stres…

This study tests whether a diet rich in fermented foods (like yogurt, kimchi, and sauerkraut) is tolerable and can improve quality of life for people who survived a critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation, which …

This study tests a home-based rehabilitation program for people who were critically ill with COVID-19. Participants use a mobile app to guide them through exercise sessions, including high-intensity interval training. The goal is to improve walking distance, fitness, and physical…

This study is testing four different seawater nasal sprays to see how well they work for people with nasal and sinus problems like colds, allergies, or after surgery. Researchers will track symptom relief, safety, and how satisfied users are. The study includes infants, children,…

This early-stage study tests a new drug called ratutrelvir in 90 adults with mild to moderate COVID-19 who are not in the hospital. Participants take the study drug plus standard care. The main goals are to check safety and find the right dose, and to see how quickly symptoms imp…

This study tests whether Astepro nasal spray, already used for allergies, can help manage COVID-19 symptoms and lower the amount of virus in the body. About 280 adults with early COVID-19 will use the spray or a placebo for 10 days. Researchers will track symptoms, viral load, an…

This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can reduce fatigue and other symptoms in people with post-COVID syndrome. About 40 adults with long COVID and chronic tiredness will receive the treatment. The main goal is to see …

This study tests a new inhaled medication called Optate for people with mild COVID-19. About 40 adults will receive either Optate or a placebo spray. Researchers will measure virus levels in the nose and track symptom changes using a quality-of-life survey.

This study tests a small device worn on the ear that sends gentle electrical pulses to nerves. The goal is to see if it can reduce pain and other symptoms in children ages 11-18 who have had a concussion or long COVID for at least 3 months. The study will measure changes in balan…

This study tests whether a structured 8-week program of physical and cognitive exercises can improve daily function, thinking skills, and quality of life in adults with Long COVID and chronic conditions like high blood pressure or diabetes. About 374 participants will be randomly…

This study tests whether a gentle ultrasound pulse to a specific brain area can improve thinking problems in people with long COVID brain fog. Researchers will compare active ultrasound to a sham (fake) treatment in 40 adults who have had brain fog for at least 4 weeks after COVI…

This study uses an online survey to identify health risks, medication problems, and self-medication habits in 2000 adults aged 18 and older. Researchers aim to understand how factors like drug interactions and polypharmacy affect active longevity. Participants complete a question…

This study looks at how COVID-19 protection changes within households in Hong Kong. Researchers will measure antibodies from vaccines and past infections in about 1,350 people. The goal is to understand how household immunity patterns evolve over time.

This study follows 150 NIH employees who plan to get the flu and/or COVID-19 vaccine. Researchers will take blood and nasal samples monthly for about a year to see how the body's immune system responds to the vaccines. No vaccines or treatments are given as part of the study—it i…

This study is collecting information and blood samples from 1,800 health care workers across eight countries to learn how different COVID-19 variants affect immunity from vaccines and past infections. Participants include adults who have been vaccinated or had a confirmed COVID-1…

This study looks at whether screening for social needs (like food or housing) and connecting people to free community services can improve health and reduce COVID-19's impact. About 1,500 adults from emergency rooms and testing sites will take part. Researchers will track changes…

This study collects nose and blood samples from people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The goal is to learn more about these viruses and how the body fights them. Samples will be stored for future research, including vaccine develop…

This study looks at whether a virtual, community-based program combining music and mindfulness can help People of African Descent manage stress, anxiety, and depression during COVID-19. About 48 participants aged 16 and older will take part. Researchers will measure brain activit…

This study looks at how pregnant and non-pregnant patients recover after being in the intensive care unit (ICU) for COVID-19 and lung failure. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after the ICU stay. The goal is to better un…

This study aims to track how common respiratory viruses like COVID-19, flu, and RSV spread in communities and households. Researchers will enroll up to 25,000 people of all ages, collecting nasal swabs and symptom reports over time. The goal is to better understand infection rate…

This study aims to understand why the protection from vaccines, like those for COVID-19, decreases over time. Healthy adults aged 18 and older who are scheduled for a new vaccine or booster shot can join. Participants will give blood samples and health updates over one year to he…

This study looks at how the COVID-19 pandemic may have changed people's physical activity, sleep, blood pressure, and mental stress. Researchers at Indiana University will track 100 adults aged 18-75 using wearable devices, fitness tests, and blood samples. The goal is to better …

This study follows 10,000 pregnant women in Nagpur, India, from early pregnancy through 42 days after birth. Researchers want to learn if catching flu, COVID-19, or other respiratory viruses raises the risk of problems like preterm labor or severe pre-eclampsia. The goal is to pr…

This study follows 2300 adults who had COVID-19 to learn why some people develop long-lasting symptoms (Long COVID). Researchers will look at medical records and track participants over time to find patterns and possible causes. The goal is to better understand and predict post-C…

This study is looking at how well antibodies in the blood and nose can neutralize the viruses that cause COVID-19 and monkeypox. Researchers will follow 30 adults who have received vaccines or antibody treatments to see how this protection changes over time. The goal is to better…

This study looks at how changes in gut bacteria (dysbiosis) may contribute to Long COVID symptoms like fatigue, brain fog, and stomach issues. Researchers will collect stool and blood samples from 400 people—half with Long COVID and half without—to compare gut health and immune f…

This study looks at whether community health workers sharing personal stories on social media can encourage people to get recommended vaccines for flu, COVID-19, and other respiratory viruses. About 1,400 health workers and their followers will take part. Researchers will measure…

This study uses heart MRI scans to understand why some COVID-19 survivors continue to have heart and lung symptoms, like shortness of breath or tiredness. Researchers will follow 510 adults who were hospitalized with COVID-19, scanning their hearts and lungs months after infectio…

This study aims to understand how COVID-19 impacts patients with cancer by asking them to fill out surveys and participate in phone interviews. Researchers will track how many people take part over 12 months. The goal is to gather information, not to test a treatment.

This study is following 800 people who had COVID-19 to learn how long the virus can remain in different parts of the body, like the nose, stool, semen, and breast milk, after they feel better. Researchers will also track how the immune system responds and any long-term health pro…

This study tests different COVID-19 treatments in people with mild symptoms to see how quickly they clear the virus from the body. About 3,800 healthy adults aged 18-60 with early COVID-19 will take part. Researchers compare antiviral drugs and antibodies against no treatment to …

This study is a large international survey that collects health information from 10,000 adults hospitalized with COVID-19. Researchers will track serious complications such as death, heart failure, and kidney problems. The goal is to better understand the course of the disease an…

This study follows 345 adults over 4 years to see how often COVID-19 leads to lasting lung, heart, or kidney issues. Researchers compare people who had COVID-19 with those who never did. The goal is to find early warning signs and create better guidelines to prevent long-term org…

This study looks at whether placing a clear plastic box over a patient's head during CPR can reduce the spread of viruses, like COVID-19, to healthcare workers. Researchers will have 240 healthcare providers perform CPR on mannequins, with and without the box, to measure how well…

This study aims to collect samples and health information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to learn how viruses behave differently in healthy individuals versus those with weakened immune sy…

This study looks at how common COVID-19 is among healthcare workers by testing for antibodies. It also checks their mental and emotional well-being during the pandemic. The goal is to learn how to better support healthcare workers and prepare for future outbreaks.

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood with the new tablet compared to the original, and whether taking it with food or as a drink changes…

This study looks at 320 adults who need strong immune-suppressing drugs and have already had at least two COVID-19 vaccines. Researchers want to know if giving a booster right before starting treatment or waiting six months provides better protection. The goal is to find the safe…

This study compares how well two FDA-approved COVID-19 vaccines (Novavax and Pfizer-BioNTech) and flu vaccines work in adults aged 18-79 who have health risks like asthma, heart disease, or depression. Researchers will measure immune responses and side effects over time. The goal…