COVID-19

This early-stage trial tested a new COVID-19 booster vaccine, STX-S, in 60 healthy adults who had already received a primary vaccine series and at least one booster. The vaccine uses tiny particles called exosomes to deliver spike proteins. The main goal was to check safety and s…

This study tested whether getting a different COVID-19 vaccine for the second shot (instead of the same one) is safe and boosts immunity. 100 healthy adults who had already received one dose of the AZD1222 vaccine were randomly assigned to get either the same vaccine or a differe…

This large, final-stage study tested a new combination vaccine that aims to protect against both COVID-19 and the flu with a single shot. About 9,300 adults aged 65 and older took part, receiving either the combo vaccine or a standard high-dose flu vaccine. Researchers checked ho…

This study tested a new vaccine designed to protect against the Omicron JN.1 variant of COVID-19. About 120 adults aged 65 and older, and teens and adults aged 12 to 64 with health conditions that increase COVID-19 risk, received one dose. Researchers checked how well the vaccine…

This study tested an updated RNA-based COVID-19 vaccine designed for the 2025-2026 season. It involved 774 participants aged 12 and older, including those 65+ and younger people with health conditions that raise their risk of severe COVID-19. Everyone received one shot, and resea…

This study tested Novavax's COVID-19 vaccine in 3,600 children aged 6 months to 12 years. The goal was to see if the vaccine is safe and triggers a strong immune response. Children received two doses 21 days apart, with some getting a placebo. The trial is complete, and results w…

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This study tested updated versions of the Pfizer-BioNTech COVID-19 vaccine designed to target newer Omicron variants (XBB.1.5, JN.1, and KP.2). Over 1,000 healthy people aged 12 and older received a single dose. The main goals were to check safety and measure the immune response.…

This large study tested Moderna's COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that increase the risk of severe COVID-19. The goal was to see how well different vaccine doses prevent COVID-19. Participants received either the original or an upda…

This study tested whether three different manufacturing batches (lots) of Novavax's COVID-19 vaccine produce the same immune response and safety in adults. About 900 healthy adults aged 18 to 49 who had already been vaccinated received one of the three lots. The results help ensu…

This large study tested the safety and effectiveness of the Pfizer-BioNTech mRNA vaccine (BNT162b2) against COVID-19 in nearly 47,000 healthy volunteers aged 12 and older. Participants received two doses of the vaccine or a placebo, and the trial also explored booster doses and p…

This study looked at whether a smaller (fractional) dose of the Pfizer-BioNTech COVID-19 booster works as well as the standard dose. It involved 601 healthy adults in Mongolia who had already received two doses of Sinopharm, AstraZeneca, or Sputnik vaccines 6 to 9 months earlier.…

This study tested the CoviVac COVID-19 vaccine in 200 healthy adults aged 60 and older. Researchers checked how safe the vaccine was and how well it boosted the immune system. The goal was to see if the vaccine could help prevent COVID-19 in this age group.

This study tested a new booster vaccine called PHH-1V in 887 adults who had already received two doses of the Pfizer COVID-19 vaccine. The goal was to see if the new booster was as safe and effective as a third Pfizer dose. The trial also looked at the effects of a fourth dose of…

This study tested different COVID-19 booster vaccines (Janssen, Moderna, Pfizer, Novavax) in about 1,900 adolescents and adults aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. Some participants had HIV, and others did not. The goal was to see if mixing vaccine t…

This study tested a new recombinant COVID-19 vaccine (made using CHO cells) in healthy people aged 3 and older. The trial involved 3,100 participants across two phases to check safety, side effects, and immune response. Participants received either a low or high dose of the vacci…

This early-stage study tested an experimental RNA-based COVID-19 booster vaccine in 383 healthy adults who had already received a COVID-19 vaccine. The goal was to find a safe dose and see how well the body's immune system responded. Researchers looked at side effects and immune …

This completed Phase 1/2 trial tested a new DNA booster vaccine called Covigenix VAX-002 in 46 healthy adults aged 18 and older. The vaccine is designed to protect against newer COVID-19 variants like Omicron. Participants had already received a primary COVID-19 vaccine or booste…

This study tested a new type of COVID-19 vaccine (ARCT-2303) in adults who had already received a COVID-19 vaccine. Some participants got the COVID-19 vaccine at the same time as the seasonal flu shot, while others got it alone. The goal was to see if the combination was safe and…

This study tested a single combined vaccine that aims to protect against both COVID-19 and influenza. About 8,800 healthy adults received either the combo shot or separate vaccines. Researchers checked for side effects and measured immune responses over six months to see if the c…

This study tested a new combination vaccine called mRNA-1083 that aims to protect against both COVID-19 and the flu with a single shot. It involved 2,457 healthy adults aged 50 and older in Japan, Taiwan, and South Korea. The main goals were to check how well the vaccine triggers…

This early-stage trial tested a new COVID-19 booster vaccine given as a nasal spray in 60 adults who had already received at least one mRNA COVID-19 booster. The main goal was to check safety and how well the body's immune system responds. The vaccine uses a harmless mouse virus …

This large Phase 3 trial tested whether giving healthy people who already received the Pfizer-BioNTech COVID-19 vaccine one or more extra doses (boosters) is safe and effective. Over 16,000 participants in several countries received either the original vaccine, a version adapted …

This phase 2 study tested several new mRNA COVID-19 booster vaccines in 692 healthy adults who had already received a primary vaccine series. The goal was to compare the safety and immune response of these experimental boosters against a control vaccine. Participants received a s…

This study tested a Novavax COVID-19 booster vaccine in 21 people with weakened immune systems due to inflammatory bowel disease or organ transplants. The goal was to see if the booster improved antibody levels and immune protection against COVID-19. Participants had already rece…

This Phase 2 trial tested updated mRNA vaccines designed to target specific COVID-19 variants, including Omicron. Over 1,200 adults who were already vaccinated received one or two doses of these variant vaccines. The goal was to see if these updated shots could boost the immune s…

This study tested three new self-amplifying RNA vaccines against COVID-19 in 72 healthy adults, some already vaccinated and some not. The goal was to check safety and how well the vaccines boost the immune system. Results help decide which vaccine candidates to study further.

This Pfizer trial tested whether a single injection combining an updated COVID-19 vaccine and a flu vaccine is safe and triggers a strong immune response. The study involved 644 healthy adults aged 50 and older. Researchers measured side effects and antibody levels to see if the …

This study tested several updated mRNA COVID-19 booster vaccines in over 1,400 healthy adults who had already received prior COVID-19 vaccines. The goal was to see if these new boosters are safe and can improve the immune response against newer Omicron variants. Participants rece…

This completed study tested Sanofi's experimental COVID-19 vaccines in over 3,000 adults aged 18 and older. The vaccines use a recombinant protein plus an adjuvant to boost immune response. The trial evaluated safety and immune responses for both a two-dose primary series and a b…

This study tested a new COVID-19 vaccine called SpikoGen in 39 adults who had never received a COVID-19 vaccine. Participants received two doses one month apart, followed by a third booster dose either one or three months later. The goal was to see how well the vaccine triggered …

This study tested a new COVID-19 booster vaccine called SpiN-Tec in 432 healthy adults aged 18 to 85 who had already received full vaccination and at least one booster. The vaccine was compared to approved boosters like Covishield and Comirnaty. The goal was to check safety and w…

This early-stage trial tested a new mRNA vaccine that combines protection against seasonal flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if a combined vac…

This study looks at health records from about 99,000 adults in Ontario who had COVID-19 and visited a pharmacist. It compares those who got Paxlovid (nirmatrelvir-ritonavir) with those who didn't, to see if the drug lowers the chance of hospitalization, ICU admission, or death wi…

This trial investigates whether famotidine, the active ingredient in Pepcid, can help relieve COVID-19 symptoms in adults who are not sick enough to be hospitalized. Participants receive either famotidine or a placebo, along with standard care, and report their symptoms remotely.…

This study looked at whether giving plasma (the liquid part of blood) from people who recovered from COVID-19 could help critically ill patients fight the virus. The plan was to collect plasma from up to 240 recovered donors and give it to sick patients. However, the plasma donat…

This small pilot study tested whether adding pegylated interferon lambda to standard care helps hospitalized adults with mild-to-moderate COVID-19 recover faster. Nine participants were randomly assigned to receive the drug or standard care alone. The study measured how long the …

This study tested a treatment called INM005, made from antibodies produced in horses, for adults hospitalized with moderate to severe COVID-19. The goal was to see if it could help patients recover faster, measured by improvement on a standard health scale 28 days after treatment…

This early-stage trial tested the safety and tolerability of a new drug called PA-001 in 47 healthy and elderly volunteers. Participants received either PA-001 or a placebo through an IV. The main goal was to see if the drug causes any side effects and to understand how the body …

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This completed study in Brazil looked at whether a fourth dose of a COVID-19 vaccine helps protect people aged 60 and older from hospitalization and death. Researchers tracked 260 elderly participants who received a second booster and compared their immune responses to samples fr…

This study looked at 84 hospitalized adults with severe COVID-19 who received the drug remdesivir. Researchers analyzed their recovery over 15 days to see how the drug affected their clinical course. The goal was to understand if remdesivir helps improve outcomes in severe cases.

This early-stage study tested the safety of an experimental oral drug called MSP008-22 in 64 healthy adults aged 18-50. The goal was to see if the drug is safe and how the body processes it. This is a first step toward possibly using it to control COVID-19, but it does not aim to…

This study tested whether common blood pressure medications (ACE inhibitors or ARBs) could improve outcomes for high-risk COVID-19 patients. Researchers enrolled 372 adults with confirmed COVID-19 who were either over 40 (outpatients) or over 18 (hospitalized). The goal was to se…

This early-stage trial tested a new cell therapy called agenT-797 in 20 hospitalized COVID-19 patients with moderate to severe breathing distress. The therapy uses immune cells from a healthy donor to calm inflammation and fight the virus. The main goals were to check safety and …

This study tested whether low-dose hydrocortisone, a common steroid, can help people with severe community-acquired pneumonia survive. Over 950 critically ill adults in intensive care received either the steroid or a placebo, alongside standard antibiotics and support. The goal w…

This Phase 2 trial tested whether combining famotidine (Pepcid) and celecoxib (Celebrex) could help people with COVID-19 recover faster. Only 4 participants were enrolled, making it too small to draw firm conclusions. The study aimed to see if these drugs could reduce symptom sev…

This completed Phase 2 study tested an oral antiviral drug called S-892216 in 282 adults with mild-to-moderate COVID-19. Participants took either the drug or a placebo tablet for a short time. The main goal was to see if the drug could lower the amount of virus in the nose and th…

This phase 3 study tested the drug sarilumab (Kevzara®) in 420 adults hospitalized with severe or critical COVID-19. Participants received either sarilumab or a placebo by IV. The main goal was to see if sarilumab speeds up clinical improvement. The trial also tracked survival, n…

This study tested the SpikoGen vaccine as a booster shot in 81 adults who had already received a full course of any COVID-19 vaccine. The goal was to see if a third or fourth dose of SpikoGen could raise antibody levels and provide protection. Researchers measured immune response…

This study tested whether the immune-modulating drug abatacept, given early to hospitalized COVID-19 patients on low-flow oxygen, helps them recover faster compared to a placebo. A total of 285 adults participated. The goal was to see if adding abatacept to standard care improves…

This completed trial tested whether colchicine, a cheap anti-inflammatory drug used for gout, can help patients with mild to moderate COVID-19 pneumonia. Sixty-six patients in Lahore were given the drug to see if it shortens hospital stays and reduces oxygen needs. The goal is to…

This study tested two new rapid tests that use a single nose swab to detect COVID-19, influenza A/B, and RSV. Researchers checked how accurate the tests are compared to standard lab methods and whether healthcare workers find them easy to use. The study involved 589 people with s…

This study evaluates how well the LumiraDx SARS-CoV-2 Ag ULTRA test detects COVID-19 when used at point-of-care locations like clinics or pharmacies. Participants with COVID-19 symptoms provide nasal and nasopharyngeal swabs, and the test results are compared to a standard lab re…

This study collected nose, throat, and blood samples from 523 adults with COVID-19 symptoms or a past positive test. The goal was to help develop and check the accuracy of a new rapid test for detecting COVID-19 antibodies and viral proteins. The test is designed to be used at th…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested whether a shallow (2 cm) or deeper (4 cm) nasal swab is better at detecting COVID-19 using rapid antigen tests. Over 300 adults in Denmark each received both swab depths, and results were compared to a standard throat PCR test. The goal was to find the best bala…

This study checked how well a new test called VitaSIRO solo™ detects COVID-19, flu, and RSV in people with respiratory symptoms. Over 1,200 participants provided nose and throat swabs. The test's accuracy was compared to standard lab methods.

This study checked whether 3D-printed nasal swabs work as well as standard swabs for diagnosing COVID-19. About 1,179 people who had COVID-19 symptoms or were recently exposed took part. Researchers compared the new swabs' accuracy and safety, like nosebleed risk, to the usual on…

This study tested whether saliva samples can detect the COVID-19 virus as well as the standard nose swab test. Over 5,000 people provided both nose swabs and saliva samples, which were compared using different detection methods. The goal was to see if a simpler, less invasive spi…

This study looked at CT scans from over 10,000 people to see if they can help diagnose COVID-19 more accurately. Researchers compared CT results with standard PCR tests and also used AI to predict which patients might need a ventilator. The goal is to make diagnosis faster and he…

This study tested a new rapid test that checks for flu A, flu B, COVID-19, and RSV using one nasal swab. Over 1,100 people with respiratory symptoms took part. The goal was to see how well the test works compared to standard lab tests.

This study checked how well a new rapid test (iHealth COVID-19/Flu A&B) can detect COVID-19 and flu A and B in people with respiratory symptoms. About 588 people with two or more symptoms provided nose swabs. The test's results were compared to a standard lab test to see how accu…

This study tested 949 adults with COVID-19 symptoms to see how well saliva samples work compared to standard nasopharyngeal swabs. Each participant gave four samples: saliva for a rapid test and for PCR, and a nasal swab for both tests. The goal was to find out which combination …

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This study tested a nose spray containing heparin, a common and safe medicine, to see if it could stop the spread of COVID-19 within households. Over 500 people who lived with someone who tested positive for COVID-19 used the spray or a dummy spray three times a day for 10 days. …

This large Phase 3 trial compared a new experimental mRNA COVID-19 vaccine (mRNA-1283) with Moderna's original vaccine (mRNA-1273) in over 13,500 people aged 12 and older. The goal was to see if the new vaccine is safer, triggers a better immune response, and prevents COVID-19 at…

This Phase 2 trial tested whether thymalfasin, a synthetic version of a natural immune-boosting protein, could prevent COVID-19 infection in 189 kidney dialysis patients. These patients are at high risk due to weakened immune systems and frequent clinic visits. The study measured…

This study tested how well two different 2023-2024 updated COVID-19 vaccines (Novavax and Pfizer mRNA) protect adults from getting sick with COVID-19. About 1,200 adults who had already received at least two mRNA vaccine doses were randomly assigned to get either the Novavax or P…

This completed study looked at whether a drug called Dimolegin can safely prevent blood clots in adults hospitalized with moderate COVID-19. A total of 184 participants took a 60 mg tablet once daily as part of their regular care. The main goal was to check for serious bleeding a…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This phase 3 trial tested whether a biologic called IMM-101 could reduce severe respiratory infections, including COVID-19, in cancer patients at higher risk. 195 participants either received three doses of IMM-101 or were simply observed. The goal was to see if the treatment cou…

This study tested whether the dietary supplement MitoQ could prevent severe viral infections, like COVID-19, in adults who had close contact with a sick person. Eighty asymptomatic adults were given MitoQ or no treatment and monitored for illness. The goal was to see if the suppl…

This study looked at whether taking a moderate dose (4,000 IU) of vitamin D daily could lower the chance of getting COVID-19 compared to a low dose (400 IU). Over 2,000 adults in the US took part for 12 months. The goal was to see if vitamin D can help prevent COVID-19 infection.

This study tested whether five infusions of stem cells from donated fat tissue could help prevent COVID-19 symptoms and hospital stays in people at high risk of exposure, like healthcare workers and first responders. The trial enrolled 53 participants who had no signs of COVID-19…

This study tested whether five infusions of a person's own stem cells (HB-adMSCs) could prevent COVID-19 symptoms and hospitalization in 51 high-risk adults, such as those over 65 or with underlying health conditions. Participants had previously banked their cells at Hope Bioscie…

This large study tested whether high-dose vitamin D3 supplements could help people recently diagnosed with COVID-19 avoid severe illness and also prevent the virus from spreading to their household members. Over 2,000 participants across the U.S. and Mongolia took either vitamin …

This study tested whether brief videos, handouts, or a short talk from ER staff could increase COVID-19 booster vaccination within 30 days. Over 900 adults from emergency departments took part. The goal was to see if simple, low-cost messaging can improve vaccine uptake.

This completed trial tested a program to increase COVID-19 vaccination among pregnant women. Over 6,900 participants were involved across OB/GYN practices. The program included training for healthcare providers, reminders, and feedback on vaccination rates. The goal was to see if…

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of…

This study tested whether a simple home program of breathing exercises and walking at least 6000 steps daily could ease long COVID symptoms like cough, breathlessness, and fatigue. Forty adults with long COVID followed the program for six weeks. Researchers tracked changes in sym…

This study tested a breathing exercise program for people with long COVID who still feel short of breath. 40 adults took part to see if the exercises could improve their breathing and daily activities compared to usual care. The goal was to find a simple way to help manage this c…

This study tested whether a gentle, noninvasive microcurrent treatment can reduce muscle pain in people who had COVID-19. Forty adults with post-COVID musculoskeletal pain were randomly assigned to receive either real or sham microcurrent therapy for 12 sessions. Researchers meas…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) helps moderate-to-severe COVID-19 patients with low oxygen levels. Thirty adults who needed extra oxygen and had risk factors like diabetes or heart disease were enrolled. The goa…

This study tested whether the Ghostly app, which guides patients through strength exercises, could help hospitalized people with stroke, COVID-19, frailty, or muscle weakness. Fifteen participants used the app during their hospital stay. The goal was to see if it was practical an…

This study tested whether the antiviral drug remdesivir could help people with Long COVID. 73 adults with confirmed Long COVID received five daily doses of the drug through an IV. Researchers measured how many people completed the treatment and tests, and how well they tolerated …

This early-phase study tested whether high doses of vitamin E (alpha-tocopherol) could reduce C-reactive protein (CRP), a marker of inflammation, in 56 adults with COVID-19. Participants were randomly assigned to receive vitamin E or a placebo. The results suggest that vitamin E …

This study looked at whether 6 weeks of special breathing exercises (inspiratory muscle training) can improve diaphragm strength and reduce shortness of breath in 18 COVID-19 survivors who still had trouble breathing. Participants had proven diaphragm weakness and no other explan…

This study tested whether using an e-health tool to guide exercise can improve fitness and quality of life in adults who had COVID-19. Seventy-seven participants who struggled with physical activity after their infection were enrolled. The experimental group used the MIA Health a…

This study tested whether having conscious COVID-19 patients with breathing problems lie face down (prone position) while on high-flow oxygen could reduce the need for a breathing tube. Over 400 adults with COVID-19 pneumonia and mild to severe acute respiratory distress syndrome…

This study tested whether two months of smell training can help people who lost their sense of smell or taste due to COVID-19. Forty adults were split into two groups: one did smell training, the other did not. Researchers measured changes using smell tests and daily diaries to s…

This study tested a special type of radiofrequency (448 kHz) combined with manual techniques to help people with ongoing breathing issues after COVID-19. 96 adults who had COVID and still had cough, shortness of breath, or fatigue for over a month received the treatment. The goal…

This study tested whether a daily breathing exercise program can help people with long COVID who have weak respiratory muscles. 44 adults with long COVID and reduced inspiratory muscle strength were randomly assigned to either breathing exercises plus physical exercise, or physic…

This study tested a brief, on-site mindfulness program for 1,000 frontline healthcare workers in a Madrid hospital during the COVID-19 outbreak. The goal was to see if it could help reduce stress right away. Participants rated how helpful it was on a scale of 0 to 10. The study w…

This study tested a home-based exercise program for people who had severe COVID-19. Twenty survivors used a smartwatch and video calls to guide their recovery. The goal was to see if it improved their walking distance, strength, and quality of life compared to usual care.

This study tests a program called SINCERE that screens people for social needs like food or housing help, then connects them to free community services with follow-up calls. Researchers want to see if this improves overall health, depression, and anxiety in 1500 adults at risk fo…

This study follows people aged 70 and older who were hospitalized with severe COVID-19 for one year after their diagnosis. Researchers aim to describe how many survive and how well they recover, including physical and mental function. The goal is to better understand the long-ter…

This study looks at anonymous health records from California and Louisiana to see if the Pfizer-BioNTech COVID-19 vaccine helps prevent post-COVID conditions (long COVID). Researchers will also track who gets vaccinated. The study includes adults with a COVID-19 diagnosis between…

This completed study looked at 25 young adults (ages 18-65) who had severe COVID-19 and now have thinking or memory problems. Researchers used a special PET-CT scan to see if there are changes in brain activity and how that relates to lung damage. The goal was to better understan…

This completed study looked at how COVID-19 affects the heart, lungs, brain, and kidneys in 202 people aged 18 to 80. Participants had imaging scans, blood tests, and other procedures to track inflammation and organ function over time. The goal was to understand why some people g…

This study used health records from over 8 million people in Taiwan to understand the effects of COVID-19 and how well the oral treatment nirmatrelvir/ritonavir works. Researchers looked at who got severely ill, needed hospital care, or died, and compared those who took the treat…

This study looked at 37 critically ill COVID-19 patients who were moved by train from overcrowded ICUs in Paris to less busy ICUs in western France. Researchers tracked how many died, got infections, needed breathing machines, and how long they stayed in the hospital. The goal wa…

This completed study used advanced MRI and CT scans to look for lasting damage in the brain, heart, lungs, and liver of 206 people who had COVID-19. Researchers compared those who were hospitalized with those who were not, to understand how the virus affects organs over time. The…

This study looked at how a person's genes might influence how sick they get from COVID-19. Researchers collected blood or saliva samples from 721 people in the U.S. who tested positive for the virus. The goal was to find genetic clues that could lead to better treatments in the f…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This completed study looked at nearly 29,000 adults who had non-cardiac surgery under general anesthesia in a large Canadian health region. Researchers wanted to see how often doctors used lung protective ventilation, a technique that uses smaller breaths and gentle pressure to r…

This study tested whether taking daily probiotic capsules for 4-5 weeks after a COVID-19 vaccine could improve the body's immune response. 138 healthy adults received either probiotics or a placebo. Researchers measured antibody levels and T-cell activity to see if probiotics mad…

This completed study looked at how often healthcare workers and first responders experienced short-term side effects (like fever or sore arm) after getting either the updated Novavax or Pfizer COVID-19 vaccine. About 660 adults who had at least one prior COVID-19 shot took part. …

This study collected blood, saliva, and eye fluid samples from 343 people with uveitis, an inflammatory eye disease that can cause vision loss. Researchers aimed to learn which genes and other factors might lead to the disease and affect treatment response. Participants were foll…

This early-stage study looked at how the experimental drug ALG-097558 behaves in 16 people with moderate liver impairment compared to healthy volunteers. The goal was to measure drug levels and safety, not to treat COVID-19. Results will help guide future dosing for patients with…

This study followed 122 COVID-19 patients who were in the ICU, along with their family members, for up to a year after leaving the hospital. Researchers measured physical health, mental well-being, and how well people returned to work and daily life. The goal was to learn about t…

This early study tests how the experimental COVID-19 drug ALG-097558 moves through the body in people with severe kidney problems compared to healthy volunteers. Twelve adults will take multiple doses of the drug. The goal is to see if kidney function affects drug levels and safe…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study involved over 2,500 people of all ages to find out which immune responses best predict protection against COVID-19 after vaccination. Researchers also tested whether local pharmacies could collect blood and nasal samples effectively. The goal is to improve future vacci…

This study collected information from 550 adults treated for COVID-19 at Methodist Health System facilities. Researchers looked at patient details, treatments given, and how well patients recovered. The goal was to better understand COVID-19 and improve future care, not to test a…

This study tested how a potential COVID-19 drug, ALG-097558, interacts with other medicines and food in 51 healthy adults. It also compared two tablet forms of the drug. The goal was to gather safety and dosing information, not to treat the disease. Results will help guide future…

This study tested whether one-on-one support from a resource navigator helps long-term care and retirement home staff access health and wellness resources. 123 staff members took part, with some getting a navigator and others not. Researchers measured changes in wellness, burnout…

This study looked at how many people in Punta Arenas, Chile, have persistent COVID-19 (long COVID) — symptoms lasting more than 4 weeks after infection. Researchers surveyed and tested 282 adults who had COVID-19, checking their physical and mental health, and looking for risk fa…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This completed study looked at 4000 COVID-19 patients in Swedish ICUs who needed a breathing machine. Researchers compared outcomes based on how soon after starting ventilation a tracheostomy was performed. The goal was to see if earlier or later timing affects how many days pati…

This study looked at 176 people who had COVID-19 and were having problems with smell, taste, or saliva. Researchers tested their senses and tried smell training as a way to help. The goal was to better understand these long-lasting symptoms and how to manage them.

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This completed study enrolled 818 adults hospitalized with COVID-19 to examine how genetic, inflammatory, and other blood markers relate to disease severity and death. Researchers tracked outcomes like recovery or death and analyzed risk factors using statistical models. The goal…

This study looked at children and young adults under 24 who had COVID-19, including those with cancer. Researchers collected samples and medical information to learn about symptoms, risk factors, and how the virus spreads. The goal was to better understand the disease in younger …

This completed study followed 917 adults with COVID-19 who were prescribed Paxlovid. Researchers wanted to see how often people test positive again after finishing the 5-day treatment. The goal is to better understand the so-called 'Paxlovid rebound' and help guide future care.

This study looked at how the immune system of people with COVID-19 responds, comparing those who had symptoms to those who did not. Researchers tested over 200 adults from households with a confirmed COVID-19 case to see if asymptomatic carriers develop antibodies. The goal was t…

This study tested a fast COVID-19 test-and-treat program in Ghana, Malawi, Rwanda, Zambia, and Zimbabwe. Researchers interviewed health officials, workers, and patients to see if the program was practical and well-liked. The goal was to learn how to set up similar programs in the…

This study followed 51 adults who survived severe COVID-19 pneumonia and needed a breathing tube for more than 72 hours. Researchers measured their quality of life, ability to perform daily activities, muscle strength, and nutrition at 1, 6, and 12 months after leaving the hospit…

This study reviewed medical records of 200 adults from an endocrinology clinic to see if taking vitamin D3 supplements lowered their chances of developing Long COVID after a COVID-19 infection or getting COVID-19 after vaccination. Researchers compared patients who took vitamin D…

This study looked at how stress from the COVID-19 pandemic affected eating behaviors and weight in over 5,000 English-speaking adults. Participants completed online surveys about their mental health, eating habits, and weight changes. The goal was to understand the link between p…

This completed study followed 530 working-age adults (18–70) who were hospitalized for COVID-19. Researchers measured disability using WHO checklists at 12 and 36 months after hospitalization. The goal was to understand how severe COVID-19 affects people's ability to function and…

This study looked at whether it is safe to give another dose of a COVID-19 mRNA vaccine to people who had a bad reaction to a previous dose, or to people with a history of allergies. It also included people with long COVID. A total of 137 adults took part and received either the …

This study looked at how the COVID-19 pandemic affected the supply of blood products for emergency surgeries at one hospital. Researchers tracked delays and shortages from March 2020 to March 2021. The goal is to use this information to create better policies for handling blood s…

This study tracked 100 fully vaccinated adults to see how many later caught COVID-19 (called a breakthrough infection). It also compared infection rates in people who got a booster shot. The goal was to understand how well vaccines and boosters protect against infection, not to t…

This study tested a blood test called ELISpot to see if it can detect the body's immune response to the COVID-19 virus. The test aims to find infections that standard swab tests might miss and help predict whether a person will develop mild or severe illness. Researchers enrolled…

This study reviewed medical records of 417 adults hospitalized with COVID-19 at four hospitals. Researchers wanted to find out how many patients also had other infections (co-infections) or developed new infections later. They also looked at how these infections affected death ra…

This completed study analyzed blood samples from 304 COVID-19 patients in France to find early immune markers that predict whether someone will become severely ill. Researchers looked at T-cells and inflammatory chemicals in the blood to understand why some people worsen while ot…

This study looked at whether a blood test measuring suPAR levels can predict which adults hospitalized with COVID-19 will develop severe breathing failure requiring a breathing tube. Researchers analyzed stored blood samples from about 367 patients. The goal was to see if a suPAR…

This early-phase study tested a radioactive tracer called 18F-αvβ6-BP in 5 people who had recovered from COVID-19. The goal was to see if the tracer could highlight lung damage on PET/CT scans. Participants received the tracer intravenously and underwent imaging. The study only a…

This study looked back at 60 adult blood cancer patients who had stem cell transplants and later developed a rare fungal infection called mucormycosis. Researchers compared cases before COVID-19 (2015-2020) to during the pandemic (2020-2024) to see if the virus, new tests, or new…

This study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…

This study followed 132 healthy smokers and non-smokers aged 30-55 to see how smoking history affects immune cells and COVID-19 risk. Participants provided blood, saliva, and nasal swab samples over up to six monthly visits. The goal is to understand why smokers may have more sev…

This completed study looked at anxiety about COVID-19 in 200 adults with rheumatic diseases who were already taking either biologic or conventional disease-modifying drugs. Researchers called participants and asked them to fill out a questionnaire about their coronavirus-related …

This study tested whether weekly community-led group discussions could improve trust and openness to COVID-19 testing and vaccination. Fifty-seven adults from nine housing agencies took part in online meetings and completed surveys over six months. The goal was to see if peer-led…

This study tested whether weekly community-led group discussions about health topics could change how people feel about COVID-19 testing and vaccines. 49 adults from housing authority agencies took part in Zoom meetings and completed surveys over 18 weeks. The goal was to see if …

This study looked at placentas from 68 women who had COVID-19 during pregnancy to see if the virus changes the placenta's structure or gene activity. Researchers also checked umbilical cord blood for signs of inflammation. The goal is to better understand how the infection might …

This study followed 75 people with cystic fibrosis (CF) for two years to see how many developed COVID-19 antibodies from infection or vaccination. Researchers wanted to know if CF patients are naturally protected or just avoiding the virus. The study collected blood samples and h…

This study looked at ways to encourage COVID-19 testing and prevention habits among people with diabetes or at risk for it. About 290 participants in Georgia were split into two groups to compare the effects of a 16-week program. The goal was to see if the program increased testi…

This study looked at whether people with cystic fibrosis (CF) have COVID-19 antibodies in their blood over two years. Researchers wanted to see if CF patients get infected less often or have milder symptoms. About 331 children and adults with CF from Europe gave blood samples and…

This study followed 283 adults who needed intensive care for severe COVID-19 lung damage (ARDS) in Poland. Researchers tracked who survived up to 4 years later and asked survivors about their quality of life, breathing, and daily function. No new treatment was tested—the goal was…

This study looked at 39 hospitalized COVID-19 patients to see if a strong T-cell immune response is linked to worse symptoms. Researchers measured specific immune cells and chemicals in the blood. The goal was to understand why some patients get much sicker, not to test a treatme…

This study followed 643 healthy adults in central North Carolina for one year to see how many developed antibodies to the COVID-19 virus. Participants had blood drawn five times and completed weekly symptom surveys. The goal was to better understand exposure rates and immune resp…

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researc…

This study looked at whether the COVID-19 virus can be found in the saliva of people who have no symptoms or only mild symptoms. Researchers collected samples from the nose, mouth, eyes, and blood, and also tested how many virus particles are released during speaking with and wit…

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes. Researchers used a needle to take samples from the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. The goal was to understa…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study looked at how T-cells, a key part of the immune system, respond to the COVID-19 virus in 51 people—hospitalized patients and healthy hospital staff. Researchers measured T-cell activity at several time points using a blood test called ELISPOT. The goal was to better un…

This study looked at whether virtual coaching helps rural pharmacists better counsel patients who are hesitant about COVID-19 vaccines. Twenty pharmacies took part, first receiving standard training and then adding one-on-one video coaching. Researchers measured how well pharmaci…

This study looked at why Spanish-speaking Latinx communities face higher rates of COVID-19 infection and lower vaccination rates. Researchers worked with community partners to understand social, ethical, and behavioral barriers. They tested a program that combines peer support an…

This completed study enrolled 760 adults who had tested positive for SARS-CoV-2 and recovered. Researchers collected blood and nasal samples to measure antibodies and immune cells. The goal was to understand how the body's immune system responds to natural infection, which could …

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This completed study tested a one-time 45-minute health education session for parents and students in Miami schools. The goal was to see if the session improved COVID-19 knowledge, confidence in health decisions, and vaccine uptake. Researchers compared responses between those wh…

This study investigated whether people hospitalized with severe COVID-19 are more likely to develop diabetes later on. Researchers followed 23 participants who had no diabetes before their infection, measuring their blood sugar levels over time. The goal was to understand how COV…

This study explored how changes in healthcare during the COVID-19 pandemic (2020-2021) impacted the quality of life and experiences of over 5,000 Dutch patients who had surgery or another medical procedure. Researchers first held focus groups to understand key themes, then create…

This completed study looked at over 6,000 adults admitted to Italian cardiac intensive care units during the COVID-19 pandemic. Researchers aimed to describe the types of patients admitted, how they were managed, and their short-term outcomes. The goal was to understand the pande…

This study looked at what helps or hinders COVID-19 testing among Black/African American adults. Researchers worked with beauty salons and barber shops to share culturally relevant videos and messages from trusted community leaders. The goal was to understand attitudes and increa…

This study aimed to understand how COVID-19 affected cancer patients and healthcare workers in cancer centers. Over 1,100 participants were followed for a year to track infections, severity, and emotional impacts. No treatments or vaccines were tested; instead, researchers collec…

This completed study from France enrolled 373 people who came to the emergency room with suspected COVID-19. Researchers checked routine blood markers to see if any could predict which patients would later get worse and need intensive care. The goal was to find simple, low-risk t…

This study looked at adults who received a COVID-19 vaccine through local programs in 7 countries. Researchers measured the immune response and how long protection lasts. About 5,400 people took part, providing blood and nose samples. The goal was to understand how well different…

This study followed over 1,100 high-risk COVID-19 patients in the Netherlands who received new antiviral drugs or monoclonal antibodies. Researchers collected blood samples and nasal swabs over 90 days to see how the virus and the body's immune response changed during treatment. …

This completed study observed 199 adults hospitalized with confirmed COVID-19. Researchers tracked patient characteristics, treatments used, and how the disease progressed over time. The goal was to answer important questions about the natural history of COVID-19 to help guide fu…

This study examined the immune systems of 120 COVID-19 patients who had trouble breathing. Researchers measured many immune markers in the blood to see if an overactive immune response causes lung damage. They also compared these markers to healthy people and looked for patterns …

This study used advanced MRI scans to look for organ damage in 693 adults who had recovered from COVID-19. Researchers focused on the heart, kidneys, and liver to see how often and how severely these organs were affected. The goal was to better understand the long-term health imp…

This early-phase study involved 36 healthy Thai adults to see if getting a COVID-19 booster and flu vaccine together is as effective and safe as getting them separately. Researchers measured immune responses and side effects over one month. The goal was to gather information to p…

This completed study followed 150 pregnant or breastfeeding women who received a bivalent COVID-19 booster. Researchers measured antibody levels in mothers, infants, and breast milk to understand how vaccination impacts immunity against COVID-19 variants. The goal was to learn mo…

This study examined whether a blood test parameter called NEU-SFL, which reflects neutrophil activation, could predict the risk of death in patients hospitalized for COVID-19 in 2021. Researchers compared NEU-SFL levels between those who survived and those who died. The goal was …

This completed study looked at blood clotting in 175 hospitalized COVID-19 patients. Researchers used a special test to measure how quickly and strongly blood clots form, and whether a protein called thrombomodulin can slow this process. The goal was to understand why some COVID-…

This study looked at 13 adults who had COVID-19 and still had symptoms like memory or nerve problems after recovery. Researchers used brain scans, memory tests, smell tests, and other exams to find possible changes in the nervous system. The goal was to better understand how COVI…

This completed study looked at whether medications used for COVID-19 or the COVID-19 vaccine can harm hearing. Researchers compared hearing test results among 90 adults aged 18-35: those who had COVID-19 and took medications, those who had COVID-19 but took no medications, and a …

This completed study from Ankara University looked at 146 severe COVID-19 patients in the ICU. Researchers measured red blood cell distribution width (RDW), a marker of variation in red blood cell size, to see if it could predict whether patients would need a breathing tube or di…

This study looked at over 2,300 children aged 0-12 who had mild cold symptoms before elective non-cardiac surgery. Researchers wanted to see if the COVID-19 pandemic changed the risks of complications like breathing problems or infections. The goal is to help doctors decide the s…

This study aimed to make COVID-19 rapid testing easier and more effective for Latino communities in San Diego County, especially near the US-Mexico border. Over 6,500 English- or Spanish-speaking adults who were patients at certain clinics or lived nearby took part. Researchers w…

This study followed over 4,200 Dutch COVID-19 patients for up to two years to learn about long COVID symptoms like exhaustion, breathing problems, and mental health issues. Researchers also looked at how these symptoms affect quality of life and what factors might predict who get…

This completed study used a special imaging method called electrical impedance tomography (EIT) to look at lung function in 100 people with long COVID who have trouble breathing, compared to 50 healthy volunteers. The goal was to see if EIT can detect changes in how air moves thr…

This completed study followed 4,235 Kaiser Permanente Colorado members to track COVID-19 antibodies and reinfection rates over 9 months. Researchers measured antibody levels and tested for new infections to see if antibody levels could predict reinfection risk. The goal was to be…

This study tested a patient engagement tool (PET) designed to encourage COVID-19 and flu vaccination among underserved populations in East London, including minority ethnic groups, migrants, and low-income individuals. Over 5,900 adults from six GP practices were randomly assigne…

This study tested a non-invasive helmet-like device to monitor brain pressure and detect tiny strokes in 60 hospitalized COVID-19 patients. The goal was to understand how COVID-19 affects the brain without using needles or surgery. Participants wore the device for one hour daily …

This completed study looked at whether smoking or using nicotine products changes the risk of catching COVID-19. Researchers surveyed over 600 healthcare workers who had been tested for the virus. The goal was to see if there is a connection between tobacco or nicotine use and te…

This study looked back at 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and a possible COVID-19 infection. The goal was to describe their symptoms, lab results, and heart function, and to figure out whether the virus directly damages the he…

This study tested two short digital videos designed to encourage COVID-19 vaccination among 1,419 adults with anxiety or depression who were not up to date on their shots. One video used 'attitudinal inoculation' to build resistance to misinformation, and the other used technique…

This completed study looked at 189 adults who had COVID-19 to see how long their immune system remembers the virus. Researchers collected blood, saliva, and nose swabs at 6 and 12 months after infection to measure antibody levels. The goal was to understand if protective immunity…

This pilot study tested a noninvasive wearable device that measures breathing, heart rate, body temperature, and oxygen levels. Researchers wanted to see if it could help screen for and monitor respiratory infections like COVID-19. Forty healthy adults performed breathing tasks w…

This study looked at whether iron deficiency anemia makes COVID-19 vaccines less effective in young women. Researchers gave intravenous iron to 121 participants and measured their immune responses. The goal was to see if correcting iron deficiency could boost vaccine protection.

This completed study looked at how the SARS-CoV-2 virus spreads within hospitals, involving over 2,000 patients, caregivers, and healthcare workers. Researchers tracked suspected and confirmed cases to identify risk factors and the effectiveness of infection control measures. The…

This completed study enrolled over 1,000 vaccinated adults who later tested positive for COVID-19. Researchers analyzed the virus's genetic code and measured antibody levels to understand which variants cause breakthrough infections and how well the immune system responds. The go…