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Major study tests moderna vaccine in High-Risk groups

NCT ID NCT05168813

Completed ⭐️ VACCINE ⭐️ Sponsor: COVID-19 Prevention Network Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large study tested Moderna's COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that increase the risk of severe COVID-19. The goal was to see how well different vaccine doses prevent COVID-19. Participants received either the original or an updated bivalent vaccine, and researchers tracked infections and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Moderna COVID-19 mRNA vaccine (mRNA-1273 and bivalent mRNA-1273.222)
What this could lead to
If successful, this could show that the Moderna COVID-19 vaccine works well in people with HIV or other conditions that raise their risk of severe COVID-19.
What could go wrong
This trial is already completed, so results are available. However, the vaccine may be less effective against new variants, and side effects like fever or fatigue can occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 HIV INFECTIONS SARS-COV-2 INFECTION

Contacts and locations

Locations

  • Aurum Institute Klerksdorp CRS

    Klerksdorp, North West, South Africa

  • Baylor-Uganda CRS

    Kampala, Uganda

  • Blantyre CRS

    Blantyre, Malawi

  • CAPRISA eThekwini CRS

    Durban, KwaZulu-Natal, South Africa

  • Cfhrz Crs

    Lusaka, Zambia

  • Clinical HIV Research Unit (CHRU)/ Helen Joseph CRS

    Johannesburg, Gauteng, South Africa

  • Emavundleni CRS

    Cape Town, Western Cape, South Africa

  • Eswatini Prevention Center CRS

    Mbabane, Hhohho Region, Eswatini

  • FAM-CRU (Family Clinical Research Unit)

    Cape Town, Western Cape, South Africa

  • Gaborone CRS

    Gaborone, Botswana

  • Groote Schuur HIV CRS

    Cape Town, Western Cape, South Africa

  • Isipingo CRS

    Isipingo, KwaZulu-Natal, South Africa

  • Joint Clinical Research Centre

    Kampala, Uganda

  • Josha Resarch CRS

    Bloemfontein, Free State, South Africa

  • Kisumu - Kombewa CRS

    Kisumu, 40100, Kenya

  • Kisumu Crs

    Kisumu, Kenya

  • Kliptown Soweto CRS

    Johannesburg, South Africa

  • MERC Kempton Park

    Pretoria, Gauteng, South Africa

  • MERC Middelburg

    Middelburg, Mpumalanga, South Africa

  • MERC Welkom

    Welkom, South Africa

  • MU-JHU Research Collaboration CRS

    Kampala, Uganda

  • Malawi CRS

    Lilongwe, Malawi

  • Masiphumelele Clinical Research Site (MASI) CRS

    Cape Town, Western Cape, South Africa

  • Matero Reference Clinic CRS

    Lusaka, Zambia

  • MeCRU CRS

    Ga-Rankuwa, Gauteng, South Africa

  • Moi University Clinical Research Centre

    Eldoret, Kenya

  • Ndlovu Research Centre CoVPN CRS

    Elandsdoorn, South Africa

  • Nelson Mandela Academic Research Unit CRS

    Mthatha, Eastern Cape, South Africa

  • Newtown Clinical Research

    Johannesburg, Gauteng, South Africa

  • PHOENIX Pharma (Pty) Ltd

    Port Elizabeth, Eastern Cape, South Africa

  • PHRU Matlosana CRS

    Klerksdorp, South Africa

  • Qhakaza Mbokodo Research Clinic CRS

    Ladysmith, KwaZulu-Natal, South Africa

  • Rustenburg CRS

    Rustenburg, North West, South Africa

  • Soweto - Bara CRS

    Johannesburg, Gauteng, South Africa

  • Synergy Biomed Research Institute

    East London, Eastern Cape, South Africa

  • Synexus Helderberg

    Stellenbosch, Western Cape, South Africa

  • Synexus Stanza Clinical Research Centre (CRS)

    Pretoria, Gauteng, South Africa

  • TASK Central

    Cape Town, Western Cape, South Africa

  • TASK Eden

    George, Western Cape, South Africa

  • Tembisa Clinic 4 CoVPN CRS

    Tembisa, Gauteng, South Africa

  • Tongaat CRS

    Durban, KwaZulu-Natal, South Africa

  • UNC Global Projects / Kamwala District Health Centre

    Lusaka, Zambia

  • UVRI-IAVI HIV Vaccine Program LTD. CRS

    Entebbe, Uganda

  • Univeristy of Cape Town Lung CRS Institute

    Cape Town, Western Cape, South Africa

  • Vulindlela CRS

    Durban, KwaZulu-Natal, South Africa

  • Wits RHI Ward 21 CRS

    Johannesburg, Gauteng, South Africa

  • Zambia Emory HIV Research Project - Ndola CoVPN CRS

    Ndola, Zambia

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