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NIH staff help unlock secrets of vaccine immunity in nose and blood

NCT ID NCT04794829

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 150 NIH staff members for about a year to see how their immune systems respond to flu and COVID-19 vaccines. Participants give monthly blood and nasal samples to measure antibodies in both the body and the nose. The goal is to understand how long immunity lasts and how it works in different parts of the body. No vaccines are given as part of the study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could help design better vaccines that protect both the body and the nose against flu and COVID-19.
What could go wrong
This is an observational study, not testing a new treatment. Results may not apply to the general public, and the small size (150 people) limits conclusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 influenza

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 INFLUENZA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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