National Institute Of Allergy And Infectious Diseases (niaid)

This study is testing a hepatitis C medication (glecaprevir/pibrentasvir) in 30 pregnant women who have hepatitis C, with or without HIV. The goal is to see if the drug is safe and works well during pregnancy, potentially curing the mother and preventing the baby from getting the…

This study tests whether adding special drugs (IL-6 and IFN-gamma blockers) to the standard stem cell transplant process can help more people with chronic granulomatous disease (CGD) get cured. CGD is a rare immune disorder that causes severe infections. The trial involves 50 peo…

This early-stage study tests a new type of flu vaccine that targets the stem of the flu virus, which changes less than the head. The goal is to see if it is safe and triggers a strong immune response. Healthy adults aged 18 to 50 who have had a flu shot since 2020 can join. Half …

This study compares a high-dose flu vaccine to the standard dose in children aged 3-17 who received a kidney, heart, or liver transplant within the past 2 years. The goal is to see if the high-dose vaccine triggers a stronger immune response and is safe. About 312 children will t…

This study tests an experimental flu vaccine called BPL-1357 in 129 healthy adults aged 18 to 55. The vaccine is given as a shot or nasal spray, and participants are later exposed to the flu virus in a controlled hospital setting to see if the vaccine prevents illness. The goal i…

This early-stage study tests two experimental mRNA vaccines designed to train the immune system to make powerful antibodies against HIV. About 40 healthy adults without HIV will receive the vaccines to check for safety and measure immune responses. The goal is to see if this appr…

This early-stage study tests whether a new two-part HIV vaccine is safe and can trigger the immune system to produce special antibodies that may fight HIV. About 42 healthy adults without HIV will receive the vaccine and be monitored for side effects and immune responses over a y…

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines in the lab using blood samples from pregnant women aged 15-25 in Mali. The goal is to find a vaccine that blocks malaria parasites from attaching to the placenta.

This study tests whether three new HIV vaccines are safe for healthy adults aged 18 to 49. Two vaccines are given as nasal sprays and one as a booster shot. Researchers will also check if the vaccines help the body fight HIV and if the viruses used in the vaccines can spread to o…

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot in the arm or as a nasal spray, with some shot versions including an adjuvant to boost the immune re…

This study tests a vaccine against cytomegalovirus (CMV) given to people before they receive a liver transplant. The goal is to see if the vaccine can lower the amount of antiviral medicine needed after the transplant. About 416 participants who are CMV-negative and waiting for a…

This study looks at how well the Shingrix vaccine works in people with HIV compared to healthy adults. Shingrix is already approved to prevent shingles, but researchers want to see if it triggers a strong immune response in people with different CD4 counts. About 225 adults aged …

This study tests two experimental vaccines designed to prevent Epstein-Barr virus (EBV) infection, which causes mono and is linked to certain cancers. About 750 healthy adults aged 18 to 29, both with and without prior EBV infection, will receive three doses of one or both vaccin…

This early-stage study tests an experimental flu vaccine called FluMos-v2, with or without an added booster (ALFQ adjuvant), in 45 healthy adults aged 18-50. Participants receive two shots about 4 months apart and are monitored for safety and immune response over 15 months. The g…

This early-stage study tests a new booster vaccine called OCU500, designed to protect against COVID-19. Unlike a shot, it is given as a nasal spray or inhaler. The study involves 80 healthy adults aged 18-64 who have already received a primary COVID-19 vaccine series and at least…

This early-stage study tests a new HIV vaccine booster called VRIPRO in 40 healthy adults aged 18–60 who previously received an HIV vaccine in the HVTN 706 trial. Participants will get three shots over 24 weeks. The main goals are to check safety and measure the immune response, …

This early-stage study tests whether belimumab, a drug used for lupus, is safe for people with idiopathic CD4 lymphopenia (ICL) — a rare condition where the body has too few CD4 immune cells, raising infection risk. About 20 adults aged 18-70 with ICL and autoantibodies will rece…

This study is for children aged 2 to 12 who have HIV and whose virus is already under control with daily pills. The goal is to see if switching to a long-acting injectable medication (shots every 4 or 8 weeks) is safe, tolerable, and works as well as pills. About 90 children will…

This study tests whether a drug called belatacept can safely replace the standard anti-rejection drug tacrolimus in heart transplant patients. The goal is to prevent organ rejection while reducing the kidney damage often caused by tacrolimus. About 66 heart transplant recipients …

This study tests a cream made with a type of good bacteria (Staphylococcus hominis A9) to see if it can safely control eczema in adults and teens. Participants will use the cream for 14 weeks, starting with a steroid cream for the first two weeks. The main goal is to see if the c…

This study looks at whether people with early relapsing multiple sclerosis (MS) can stop taking the drug ocrelizumab after two years and still stay relapse-free. About 123 participants will receive the drug for two years, then be randomly assigned to continue the drug or switch t…

This study compares a stem cell transplant (AHSCT) to the best standard treatments for people with relapsing multiple sclerosis that hasn't responded to other therapies. About 156 participants will be randomly assigned to one of the two groups and followed for six years. The goal…

This study tests whether giving very early and intensive HIV medicines, with or without an extra antibody, can help babies control the virus without needing lifelong daily drugs. Researchers will enroll over 1,100 infants born with HIV and monitor them closely. The goal is to see…

This study in Botswana tests whether a combination of three lab-made antibodies can safely control HIV in children who started treatment early. About 41 kids will either receive the antibodies or pause their regular HIV medication under close monitoring. The goal is to see if the…

This study tests an oral drug called letermovir in 12 infants born with symptomatic congenital CMV, a virus that can cause hearing loss and developmental problems. The goal is to find the right dose and check how the body processes the drug. Babies will also receive standard trea…

This study tests whether liver transplant recipients can safely stop taking one anti-rejection medicine (tacrolimus) and use only everolimus to protect their kidneys. About 340 adults who received their first liver transplant will join. The goal is to see if this approach keeps t…

This study tests a drug called ublituximab for people with a rare autoimmune muscle disease (IMNM) that causes weakness. It involves 30 adults with early, active disease who have specific antibodies. The goal is to see if adding ublituximab to standard care improves muscle streng…

This study tests a pill called soquelitinib in 15 people aged 16 and older with a rare immune condition called ALPS-FAS. The drug aims to reduce the size of the spleen and lymph nodes, which often become enlarged in this disease. Participants take the pill twice daily for a year,…

This study tests whether injecting Berinert (C1 esterase inhibitor) directly into a deceased donor kidney before transplant can improve kidney function one year later. About 180 adults on dialysis awaiting a kidney transplant will receive either the drug or a placebo. The goal is…

This early-stage study tests the safety of an experimental oral drug called VNT-101 in healthy adults aged 18 to 59. The study will give single or multiple doses to see how the body handles the drug and if any side effects occur. It does not aim to treat or cure influenza, but to…

This early-stage study tests whether lab-made antibodies that target HIV are safe and how the body processes them. About 83 healthy adults without HIV will receive the antibodies through an IV or under-the-skin shots, alone or combined. The goal is to check for side effects and m…

This study tests a gene therapy for people aged 2 to 50 with X-linked severe combined immunodeficiency (SCID-X1), a condition that leaves the body unable to fight infections. Participants receive a mild chemotherapy drug to prepare their bone marrow, followed by an infusion of th…

This study tests whether adding the drug lenacapavir to standard HIV treatment can reduce the hidden HIV reservoirs that remain in the body. About 50 adults with well-controlled HIV will either add lenacapavir or continue their usual therapy. Researchers will measure changes in t…

This early-stage study tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people unable to fight off infections. Researchers take a participant's own white blood cells, add a corrective mRNA instruction, and return the cells to the body.…

This study tests whether adding the experimental drug VIB4920 to standard lupus kidney treatments (mycophenolate mofetil and prednisone) can improve kidney function in people with active lupus nephritis. About 74 adults with lupus and kidney inflammation will receive either VIB49…

This study is for people age 3 and older who have or may have a parasitic infection, such as malaria or intestinal worms. Participants will receive standard medical tests and treatments—no experimental drugs are involved. The goal is to diagnose, treat, and monitor the infection …

This early-phase study tests whether the drug vorinostat is safe and can help control moderate-to-severe Crohn's disease. Participants who respond well may then receive long-term maintenance therapy with another drug, ustekinumab, for up to two years. The goal is to reduce gut in…

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra) without the disease coming back. Participants must have been on high-dose tocilizumab for at least a year and off steroids for thre…

This early-stage trial tests a new gene-editing approach for X-linked chronic granulomatous disease (CGD), a rare immune disorder. Researchers will take stem cells from 10 adult males, fix a specific genetic mutation using base editing, and return the corrected cells after mild c…

This study tests whether adding dupilumab to current treatments can help adults with hypereosinophilic syndrome (HES) who still have symptoms. HES causes too many eosinophils, damaging organs like lungs and skin. Participants will receive dupilumab injections for up to 48 weeks w…

This study tests if the drug ruxolitinib can help hair regrow in people with APECED, a rare immune disorder that causes severe hair loss. About 70 people aged 12 to 75 will take the pill twice daily for 8 months. The goal is to see if hair regrows and if other immune-related symp…

This study tests whether adding belimumab to rituximab works better than rituximab alone for people with membranous nephropathy, a kidney disease caused by the immune system attacking the kidneys. About 58 adults aged 18 to 75 with confirmed disease will receive either the combo …

This study tests whether the drug Belumosudil can prevent chronic lung allograft dysfunction (CLAD), a form of long-term rejection, in 234 lung transplant recipients who show early signs of lung injury on biopsy. Participants will take Belumosudil or a placebo for 52 weeks alongs…

This study tests two drugs, carfilzomib and belatacept, along with standard steroids and immune-suppressing medicines, in 25 kidney transplant patients who have signs of rejection. The goal is to see if this combination is safe and can reduce harmful antibodies that attack the ne…

This study involves 800 adult first-time kidney transplant recipients. Researchers will use a blood test (molecular mismatch score) to identify those at higher risk for rejection. Six months after transplant, 300 eligible participants will be randomly assigned to switch from tacr…

This study tests whether giving powerful HIV antibodies along with standard antiretroviral therapy (ART) to people newly infected with HIV can help control the virus after stopping ART. 48 adults with acute HIV infection will receive either the antibodies or a placebo, plus ART. …

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This study tests whether adding tocilizumab (a drug that reduces inflammation) to standard anti-rejection medicines can prevent chronic lung allograft dysfunction (CLAD) in lung transplant recipients. 350 adults receiving their first lung transplant will be randomly assigned to g…

This study tests whether two drugs, everolimus and epoetin, can help liver transplant patients safely stop taking their standard anti-rejection medication (tacrolimus). About 20 adults who are 1-10 years post-transplant and stable on tacrolimus will switch to everolimus, receive …

This study tests new combinations of drugs for adults with lung tuberculosis (TB) to see if they work faster and are safer than the current standard treatment. About 315 participants will receive either a new drug mix or the usual treatment for 8 weeks, then all continue standard…

This study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month regimen for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter treatment is just as s…

This study tests whether a special HIV vaccine, combined with an immune booster (vesatolimod) and two powerful antibodies, can help people with HIV control the virus after stopping their daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment very ear…

This study tests a one-time gene therapy for a rare immune disease called CD40L-HyperIgM syndrome, which causes severe infections and autoimmune problems. One male participant will receive his own stem cells and T cells that have been corrected in the lab using a precise editing …

This study tests a drug called emapalumab in 10 people with APECED, a rare disease where the immune system attacks the body, causing severe gut inflammation (enteritis). Participants receive 7 doses over 6 months, and researchers track symptom changes and side effects. The goal i…

This study tests whether daratumumab is safe for people with antiphospholipid syndrome (APS), a condition that causes abnormal blood clots. About 22 adults will receive different doses of the drug to find the highest safe dose. The goal is to see if daratumumab can help control t…

This study compares two drug combinations for children aged 13-20 who receive a kidney transplant. One group gets belatacept and sirolimus, the other gets standard drugs tacrolimus and MMF. The goal is to see which combo better prevents organ rejection and keeps the kidney workin…

This study tests a new drug called NT-I7 in people with idiopathic CD4 lymphopenia (ICL), a rare condition where the body lacks key immune cells called CD4 T cells. The goal is to see if NT-I7 can safely increase these cells and help prevent severe infections. About 60 adults age…

This study tests whether transplanting healthy donor stool into the gut can reduce colon inflammation in people with chronic granulomatous disease (CGD) and colitis. About 20 participants aged 10–60 will receive the transplant during a colonoscopy and be followed for 6 months. Th…

This study is testing whether Mozobil, a drug already used for bone marrow transplants, can safely improve white blood cell counts in adults with WHIMS syndrome. WHIMS is a rare genetic disorder that causes severe infections, warts, and low white blood cells. Researchers will giv…

This study compares a new, less invasive test called the esophageal string test (EST) to standard methods for diagnosing H. pylori, a stomach bacteria that can cause ulcers and cancer. About 25 adults with persistent H. pylori infection will swallow a capsule with a string that c…

This study aims to see if a simple, low-cost esophageal string test can accurately diagnose eosinophilic esophagitis (EoE), a condition causing swallowing trouble. Researchers will compare the string test results with standard endoscopy in 70 African adults with dysphagia in Mali…

This study tests whether a single dose of L9LS, a lab-made antibody, can safely prevent malaria in women aged 18-49 in Mali. About 290 participants will receive either the antibody or a placebo and be monitored for infections and side effects over 24 weeks. The goal is to find a …

This study tests whether giving special antibodies (PGT121.414.LS and VRC07-523LS) to newborns exposed to HIV is safe and how long they stay in the body. About 48 infants will receive one or two doses soon after birth. The goal is to see if these antibodies can help prevent HIV i…

This study tests whether a combination of three lab-made antibodies, given through an IV, is safe and can help prevent HIV in healthy adults. About 200 participants aged 18-65 will receive the antibodies or a placebo and be followed for 18 months. The goal is to see if this appro…

This study tests if a spray made from ground cardamom seeds and a harmless skin bacteria (Roseomonas mucosa) can improve eczema symptoms in people aged 2 and older. Participants apply the spray 2-3 times a week for 14 weeks, and researchers track changes in rash severity and side…

This study compares two drugs, pramipexole and escitalopram, to see which better treats depression in people with HIV. It includes those with mild memory or thinking problems. About 186 adults will take one of the medications for several weeks, and researchers will track mood cha…

This early-stage study tests whether baricitinib, a drug already approved for other immune conditions, is safe and tolerable for people with Job syndrome (a rare genetic immune disorder) who also have lupus-like disease or severe eczema. About 20 participants aged 12 and older wi…

This study collects nose and blood samples from people aged 3 and older who have or may have a respiratory virus like flu or COVID-19. The goal is to learn more about these viruses and how the body fights them. Samples will be stored for future research, including vaccine develop…

This study will follow about 9,500 women of childbearing age in Kalifabougou, Mali, to track pregnancy outcomes and malaria infections. Researchers will collect data through regular health visits and surveys, but no new treatments or drugs are being tested. The goal is to better …

This study looks at people who get frequent or unusual infections, along with their family members, to find the genetic and biochemical causes of immune system problems. Researchers will collect blood, saliva, urine, and other samples to better understand these defects and develo…

This study looks at people with Common Variable Immunodeficiency (CVID) and similar immune system problems to learn how these conditions develop and change over time. Researchers will collect blood, urine, and other samples, and perform tests like CT scans to track the disease. T…

This study will analyze the DNA of up to 20,000 people to find genetic causes of immune-related conditions like allergies, autoimmunity, and primary immunodeficiencies. Participants are already enrolled in other NIH studies, and their blood or saliva samples will be sequenced. Th…

This study looks at immune cells in the lymph nodes of 16 cat-allergic adults. Half are on long-term allergy shots, half are not. Researchers will take samples from lymph nodes, blood, and nose after a controlled cat allergen exposure to see how the immune system responds. The go…

This study aims to understand why some people develop severe, hard-to-treat HPV infections while others don't. Researchers will collect medical history, blood, and tissue samples from 850 participants aged 3 and older, including healthy relatives. The goal is to find genetic and …

This study looks at how common chemicals in pollution, food, and personal care products affect our health. Healthy adults aged 18 to 80 will stay in a hospital room for two separate 7-day periods—one in a 'pure' room with filtered air and unprocessed foods, and another with typic…

This study collects blood, urine, stool, and other samples from up to 150 healthy volunteers aged 18 to 85. Researchers will use these samples to compare with those from patients who have too many eosinophils, a type of white blood cell that can cause disease. The goal is to bett…

This study aims to learn more about tuberculosis (TB) by collecting blood and other samples from people who have active or latent TB. Researchers want to better understand how the disease works and how it affects the body. Participants will provide samples and may receive treatme…

This study looks at how immune system diseases can cause problems in the brain and nerves, such as trouble moving, thinking, or feeling. Researchers will study 350 people aged 2 and older who have an immune disease, along with their healthy relatives and other healthy volunteers.…

This study aims to learn how Staphylococcus aureus bacteria interact with human cells to cause infections, especially in the spine. Researchers will use tonsil tissue discarded after routine surgery and nasal swabs from 500 participants aged 2 and older. The goal is to build a la…

This study aims to learn more about immune system problems that cause frequent infections or inflammation. Researchers will observe up to 3,500 patients, their family members, and healthy volunteers over one year. The goal is to track how these diseases progress and find genetic …

This study aims to find out what causes fevers in Cambodia, especially those spread by insects like mosquitoes. Researchers will use advanced DNA testing on blood samples from 6,500 people with fever. The goal is to better understand and diagnose these diseases in the future.

This study aims to find the right dose of a flu virus that can safely cause mild flu symptoms in healthy adults. About 90 volunteers aged 18 to 55 will be given either the virus or a placebo. The goal is to create a reliable model for testing future flu vaccines and treatments.

This study is creating a large collection of samples (like stool, saliva, and skin swabs) from up to 600 people of all ages, both healthy and with various conditions. The goal is to help researchers learn how the tiny organisms living in and on our bodies affect our health and pl…

This study looks at people with known or suspected inflammatory or infectious diseases that aren't covered by other research protocols. The goal is to evaluate and treat these patients using standard medical practices while gathering information to help train doctors and design f…

This study follows 150 NIH employees who plan to get the flu and/or COVID-19 vaccine. Researchers will take blood and nasal samples monthly for about a year to see how the body's immune system responds to the vaccines. No vaccines or treatments are given as part of the study—it i…

This study looks at how the immune system of healthy adults in Cambodia reacts to viruses that can spread from animals to humans. Researchers will collect blood samples from 400 people aged 18 to 65 who have close contact with animals or live near animal habitats. The goal is to …

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) soon after starting HIV medications. Researchers will use PET scans, blood tests, and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is t…

This study aims to learn more about cryptococcosis, a fungal infection, in adults who were previously healthy and have no known immune problems. Researchers will collect medical records and samples from 800 participants to understand the full range of symptoms, how the immune sys…

This study collects blood stem cells and immune cells from healthy volunteers and patients with immune or blood disorders. The cells are used in the lab to develop new gene and cell therapies. Up to 850 adults aged 18-70 will participate. The goal is to create better treatments f…

This study aims to understand why some people are more prone to fungal infections, especially those with immune system problems. Researchers will collect blood, saliva, and tissue samples from affected individuals, their close relatives, and healthy volunteers. No treatment is gi…

This study follows 600 people with GATA2 deficiency, a genetic condition that can affect the immune system and other body systems. Researchers will track participants for up to 15 years to learn why some have mild symptoms while others face serious problems like infections or can…

This study looks for genes that cause certain immune system problems. It includes up to 5,000 people with known or suspected genetic immune disorders and their family members. Researchers collect blood, cheek swabs, or skin samples to find genetic changes and learn how these cond…

This study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other infections. Researchers will study up to 1,000 participants with NTM, Job syndrome, or cystic fibrosis to understand the genetics, symptoms, and best treatments…

This study aims to understand why the protection from vaccines, like those for COVID-19, decreases over time. Healthy adults aged 18 and older who are scheduled for a new vaccine or booster shot can join. Participants will give blood samples and health updates over one year to he…

This study looks for immune system problems that might make some people get very sick from viruses like herpes, chickenpox, or HPV. Researchers will test blood and skin samples from up to 600 people who have had severe viral infections, along with their relatives. The goal is to …

This study aims to learn more about what causes food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will follow up to 1,800 people aged 2 to 99, including those with allergies, their relatives, and healthy volunteers, for up to 12 years. Pa…

This study creates a large collection of blood, tissue, and health data from 10,000 people with allergies, asthma, eczema, or sinus problems. Participants aged 3 to 100 will provide samples and answer questionnaires over 1 to 3 years. The goal is to help researchers better unders…

This study aims to discover new genes that cause immune system disorders by evaluating up to 500 patients and their relatives. Participants may provide blood, saliva, or tissue samples and undergo medical tests. No experimental treatments are offered; the goal is to better unders…

This study aims to learn why some pregnant women and young children get malaria while others don't, by tracking up to 15,000 participants in Mali over several years. Researchers will collect blood samples and health data to identify immune and parasite factors linked to infection…

This study aims to learn how the immune system responds to vaccines and natural infections by collecting blood, urine, saliva, and tissue samples from healthy adults aged 18 and older. Participants may also undergo procedures like bronchoscopy or colonoscopy to provide samples. T…

This study looks at how anthrax affects the body and how the immune system responds. It includes people who have or had anthrax, those exposed to it, and healthy people who got the anthrax vaccine. Researchers will collect blood, swabs, and other samples over time to learn more a…

This study screens up to 2,000 people who have or may have a weak immune system that makes them prone to infections, along with their healthy blood relatives. The goal is to find the causes of these immune problems and improve how they are diagnosed and treated. Participants unde…

This study collects biological samples like blood, saliva, and urine from people with blood disorders (such as sickle cell disease and thalassemia) and healthy volunteers. The goal is to help researchers better understand these conditions and related diseases like malaria. Partic…

This study looks at how the immune system controls inflammation in the gut for people with Crohn's disease or ulcerative colitis. Up to 1,000 participants, from newborns to age 75, will receive standard medical care while researchers collect blood, tissue, and other samples. The …

This study aims to learn more about PFAPA, a condition that causes repeated fevers, sore throats, and mouth ulcers in children. Researchers will collect blood, saliva, stool, and tonsil tissue from 1,500 people with PFAPA or other tonsil problems. No new treatments are tested; th…

This study looks at whether a newer kidney function test (Cystatin C) can help doctors give the right dose of two common antibiotics (meropenem and cefepime) to critically ill ICU patients with drug-resistant infections. About 200 adults will participate to see if this test works…

This study looks at why certain white blood cells (eosinophils) become overactive in people with allergies, parasitic infections, or rare immune conditions. Researchers will observe up to 800 participants aged 1 to 100, using blood tests, bone marrow samples, and other exams—but …

This study looks at 200 people aged 3-21 with eczema and high allergy antibody levels to improve how doctors test for milk and peanut allergies. Participants will eat small amounts of the suspected food under medical supervision to see if they truly react. The goal is to find bet…

This study looks at why some people with tuberculosis (TB) feel worse after starting treatment, even though they initially improved. Researchers will follow 140 adults on TB therapy, with or without these paradoxical reactions, using blood tests, urine samples, and PET/CT scans t…

This study collects blood, saliva, and other samples from up to 3000 people with primary immunodeficiency (PID) or their relatives. The goal is to find genetic causes and better understand these inherited immune disorders. No treatment is given; the focus is on research to improv…

This study looks at how healthy people's skin reacts to tick bites. Researchers will place clean, lab-raised ticks on participants' skin to study the immune response. The goal is to gather information that could help develop a vaccine against ticks and tick-borne diseases like Ly…

This study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like limb swelling, blindness, and heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical test…

This study aims to understand why a small group of people with HIV, called long-term non-progressors, can control the virus for years without antiretroviral therapy. Researchers will collect white blood cells and plasma from up to 400 participants through apheresis or blood draws…

This study follows 700 people with Down syndrome (and some healthy relatives) for up to 15 years to understand how their immune system changes over time. Researchers will look at infections, autoimmune problems, and blood cancers, and compare those who had part of their thymus re…

This study screens healthy adults aged 18 to 60 to see if they can join future vaccine and antibody trials at the NIH. Volunteers give blood and urine samples and have a physical exam, but do not receive any experimental treatment. The goal is to build a pool of eligible particip…

This study looks for the genetic causes of inherited immune system problems that affect white blood cell balance. It involves up to 5,000 people with suspected immune disorders and their relatives. Researchers will review medical records and collect blood samples to identify dise…

This study uses a procedure called leukapheresis to collect large numbers of white blood cells from people with HIV. Researchers want to compare immune function in those treated soon after infection versus those treated later. The study does not provide any treatment—it only coll…

This study aims to find the genetic mutations that cause chronic active Epstein-Barr virus (CAEBV), a rare and serious disease mainly affecting children and young adults. Researchers will analyze blood and tissue samples from up to 50 patients and 150 relatives, plus anonymous do…

This study looks at why some people in Mali get allergic diseases like asthma or eczema. Researchers will collect samples and health info from 288 people with and without allergies. They will compare germs on the skin and in the gut, plus environmental factors like pollution, to …

This study aims to understand how malaria develops in the body and how it spreads from people to mosquitoes. Healthy adults aged 18 to 54 will be infected with a malaria parasite through donated blood and closely monitored. Participants will stay at the clinic for several days, h…

This study follows 600 adults with HIV in the Washington, D.C., area to monitor their health over time. Participants visit the clinic every 3-4 months for check-ups and blood tests. The goal is to collect data for research and help train infectious disease doctors. No experimenta…

This study looks at people with severe or hard-to-treat Valley Fever, a lung infection caused by a fungus found in the southwestern U.S. and parts of the Americas. Researchers want to understand why some people get very sick by studying their immune systems, genetics, and the fun…

This study looks at how leishmaniasis, a parasitic disease, affects people and how it responds to different treatments. Researchers will collect blood and tissue samples from up to 289 participants aged 3 to 100 with known or suspected infection. The goal is to learn more about t…

This study follows 500 people with neurocysticercosis, a brain infection caused by pork tapeworm larvae, to see how well current treatments work over many years. Researchers will track symptoms like seizures and headaches, and collect blood, urine, and spinal fluid samples. The g…

This study aims to improve how doctors evaluate and treat people exposed to dangerous germs like anthrax or new flu strains. It will enroll up to 200 people, including patients and healthcare workers, to collect data and provide standard or experimental care. The goal is to learn…

This study collects blood, urine, skin swabs, and other samples from healthy volunteers to help researchers at the Vaccine Research Center study diseases like HIV and hepatitis. Participants must be 18 or older and can donate samples once or multiple times over a year. The sample…

This study looks at whether signs of inflammation in spinal fluid can predict which multiple sclerosis (MS) drugs a person will respond to. About 250 adults with progressive MS will take one or two study drugs for up to 18 months. Researchers will track changes in disability and …

This study collects blood plasma and white blood cells from healthy volunteers and patients using a procedure called apheresis. The samples are used in laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH study or be a healthy vo…

This study aims to understand how the immune system and skin healing are connected. Researchers will study people with primary immune deficiency, eczema, or psoriasis, as well as healthy volunteers. Participants will provide blood and skin samples to help identify differences in …

This study enrolls healthy adults who are already part of a respiratory virus challenge study at the NIH. Participants wear a smartwatch and use a smartphone to track things like temperature, heart rate, coughing, and voice changes. The goal is to see if these digital devices can…

This study looks at why some HIV drugs cause weight gain. Healthy volunteers aged 18 to 55 will take one of four HIV medications for 4 weeks. Researchers will measure changes in blood, fat tissue, and body composition to understand the early metabolic effects. The goal is to find…

This study aims to learn more about idiopathic CD4+ lymphocytopenia (ICL), a rare condition where the body has too few CD4+ immune cells, leading to infections or autoimmune problems. Researchers will follow about 950 participants for up to 10 years, collecting medical history, b…

This study aims to understand why some people with immune system problems get severe or unusual fungal infections. Researchers will collect blood, saliva, and tissue samples from up to 1,200 participants, including patients, their relatives, and healthy volunteers. The study will…

This study aims to collect samples and health information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to learn how viruses behave differently in healthy individuals versus those with weakened immune sy…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow up to 600 patients and their relatives over time, using exams and genetic tests to understand the disease better. No new treatments …

This study follows people with Autoimmune Lymphoproliferative Syndrome (ALPS) and their relatives over many years. Researchers aim to learn how the immune system goes wrong, what genes are involved, and how the disease changes over time. Participants visit the NIH once a year for…

This study aims to learn how the immune system reacts to COVID-19 during and after infection, and why some people get very sick while others have no symptoms. It will collect blood and stool samples by mail from up to 5,000 people of all ages, including those with confirmed or su…

This study aims to learn more about inflammatory diseases of the brain and spinal cord, such as multiple sclerosis (MS), which may be caused by the immune system attacking the body. Researchers will compare tests from 2,400 people—both healthy volunteers and those with symptoms o…

This study looks at why mast cells grow too much in people with mastocytosis, a condition that can cause itching, bone pain, and stomach pain. Researchers will collect blood and bone marrow samples from up to 600 participants during a single 8-hour visit. The goal is to learn mor…

This study is for people with active Lyme disease. Its main goal is to learn more about the infection by following patients over time. Participants will receive standard medical tests and FDA-approved treatments. The study does not test any new drugs or procedures.

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood and other biological samples from up to 2,419 adults, both with and without HIV. Researchers will compare these samples to better understand the virus and related immune de…

This study is for people with autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn what causes these diseases, how they change over time, and how they affect the body. Participants will have medical tests, i…

This study looks at people who still feel sick after being treated for Lyme disease. Researchers want to find out if the Lyme bacteria are still alive in the body and causing these ongoing symptoms. Up to 700 participants, including those with chronic Lyme, recovered patients, an…

This study collects samples like blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. The samples are used to develop and improve research tests, not to treat any disease. Participants may be asked to give samples over 5 years, with visits lasting about …

This study looks at where HIV hides in the body by comparing virus levels in blood, lymph nodes, and bone marrow. Researchers want to understand how HIV damages the immune system and why it persists even with treatment. About 400 adults with HIV will provide blood and tissue samp…

This study looks at the genetic causes of primary immunodeficiency disorders (PIDs), which weaken the immune system. Researchers will compare people with PIDs, their healthy relatives, and healthy volunteers to find genetic differences. Up to 2,500 participants aged 0-90 will pro…

This study aims to understand why some adults develop a severe immune condition called secondary hemophagocytic lymphohistiocytosis (sHLH), which causes dangerous fevers and inflammation. Researchers will follow 300 adults with sHLH for up to a year, collecting blood samples and …

This study screens healthy adults aged 18 to 50 to see if they can join future malaria research trials. The goal is to find safe and effective malaria vaccines, drugs, or prevention methods. Participants will have a medical history check, physical exam, and blood and urine tests.…

This study aims to understand how certain bacteria avoid being killed by our immune cells. Researchers will collect blood from up to 200 healthy volunteers to study these interactions in the lab. No treatments or drugs are tested; the goal is simply to learn more about how bacter…

This study follows about 50 family members who have a genetic condition causing high levels of a type of white blood cell (eosinophils), which can damage organs like the heart and nerves. Researchers will track participants over many years with yearly check-ups, blood tests, and …

This study screens healthy adults aged 18 to 65 to see if they can join future research on infectious diseases like flu and Zika. Volunteers undergo a medical check-up, blood tests, and heart exam. No treatment is given—the goal is to build a pool of eligible participants for lat…

This study is for people with idiopathic CD4 lymphocytopenia (ICL), a rare condition that causes low CD4 T cells and raises infection risk. Researchers will give participants and healthy volunteers two drugs to move stem cells from bone marrow into the blood, then collect them. T…

This study tests a new tracer for PET/CT scans that may find protein clumps (amyloidosis) in organs without needing a biopsy. It involves 30 adults with CAPS who developed amyloidosis from anakinra injections. Participants will have scans every 6 months for 2 years to track chang…

This study is observing people who previously participated in type 1 diabetes treatment trials. Researchers will follow them for up to five years to see how long their bodies continue to produce insulin naturally and how their immune systems change over time. The goal is to gathe…