National Institute Of Allergy And Infectious Diseases (niaid)

This early-stage study tested whether a new HIV vaccine was safe and could trigger an immune response in healthy adults aged 18 to 50. The vaccine was given alone or with other HIV vaccines in different schedules. The study was terminated early, so results are limited.

This early-stage study tested a nasal spray vaccine against Ebola in 15 healthy adults. The vaccine uses a weakened common cold virus to deliver a piece of the Ebola virus, aiming to teach the body to fight off infection. The trial was stopped early, but researchers were checking…

This study tested four different doses of a drug called siplizumab in people aged 8 to 45 who were diagnosed with type 1 diabetes within the last 18 months. The goal was to find a safe dose that could help preserve the body's ability to produce insulin by changing certain immune …

This study tested the drug elotuzumab for people with active IgG4-related disease (IgG4-RD), a rare condition where the body attacks its own tissues. The trial aimed to see if adding elotuzumab to standard steroid treatment was safe and effective. Only 8 people enrolled before th…

This study tested two lupus medications—mycophenolate mofetil alone or with voclosporin—in 12 adults with moderate-to-severe lupus. Researchers wanted to see if treatment response differs based on a person's immune system type. The goal was to find better ways to tailor therapy, …

This study tested whether adding a 12-week course of VIB4920 to standard TNF-inhibitor therapy could improve disease control in people with rheumatoid arthritis who did not respond well to TNF-inhibitors alone. Only 2 participants were enrolled before the study was stopped. The g…

This study tested whether the drug tecovirimat can safely treat mpox and speed up recovery. About 719 people with mpox took either tecovirimat or a placebo. The main goal was to see if the drug helped skin lesions heal faster and reduced pain. The trial was stopped early, and res…

This study tested a small device that sends mild electrical pulses through the skin to stimulate the vagus nerve, aiming to reduce pain and inflammation in children with juvenile idiopathic arthritis (JIA). The trial planned to enroll 18 participants aged 5-18, comparing the acti…

This study looked at whether taking estrogen therapy changes the levels of HIV drugs in the blood of transgender women. About 93 adult transgender women living with HIV who were already on stable HIV treatment took part. The goal was to see if the HIV drugs still work well and if…