National Institute Of Allergy And Infectious Diseases (niaid)

This study tested the safety and immune response of a new experimental Ebola vaccine given as a nasal spray. It involved 15 healthy adults who received two doses of either the vaccine or a placebo. The main goals were to check for side effects and see if the vaccine triggered an …

This study tested whether adding a new drug called VIB4920 to standard arthritis medication (TNF inhibitors) could better control rheumatoid arthritis in adults whose current treatment wasn't working well enough. It was a Phase 2 trial that planned to enroll 104 participants but …

This large study tested whether the antiviral drug tecovirimat could safely and effectively treat mpox. Over 700 participants with mpox were randomly assigned to receive either the drug or a placebo for 14 days. The trial was stopped early after an independent review board found …

This study tested whether adding the drug elotuzumab to standard steroid treatment (prednisone) could better control IgG4-Related Disease (IgG4-RD), a chronic condition that causes inflammation and scarring in various organs. It involved about 75 adults with active disease affect…

This early-stage study tested different doses of an immune therapy called siplizumab in people recently diagnosed with type 1 diabetes. The main goal was to find a safe dose that changes certain immune cells, which might help protect the body's remaining insulin-producing cells. …

This study aimed to see if two different drug combinations could better control active systemic lupus erythematosus (SLE) in specific groups of patients. It tested mycophenolate mofetil (MMF) alone or combined with voclosporin in adults with moderate to severe, non-organ-threaten…

This study tested a device that delivers mild electrical pulses through the skin to stimulate a nerve in the ear, aiming to reduce pain and inflammation in children with juvenile idiopathic arthritis (JIA). Participants, aged 5-18, used the device at home daily for 8 weeks while …