National Institute Of Allergy And Infectious Diseases (niaid)

This study tested whether taking doxycycline for 3 days works as well as the standard 7-day course to cure chlamydia. About 664 men and women with chlamydia took either a 3-day or 7-day regimen, and were tested again after 28 days. The goal is to see if a shorter treatment can be…

This study tested an experimental smallpox vaccine called IMVAMUNE in 226 healthy adults who had never received a smallpox vaccine. Participants received either the vaccine or a placebo, and researchers monitored side effects and immune responses for up to 425 days. The goal was …

This early-stage trial tested an experimental mRNA vaccine (mRNA-1215) for Nipah virus, a serious disease spread from animals and people. Forty healthy adults received two shots, one month apart, and were monitored for safety and immune response over about a year. The vaccine can…

This study looked at whether adding special ingredients called adjuvants to two standard flu vaccines (Fluzone and Flublok) could improve the body's immune response. About 240 healthy adults aged 18-45 received either a vaccine alone or a vaccine with an adjuvant. Researchers che…

This study tested whether an experimental HIV vaccine could prevent infection in over 5,400 sexually active adults in South Africa. Participants received either the vaccine or a placebo and were followed for up to 36 months. Unfortunately, the vaccine did not provide enough prote…

This study tested whether the MVA-BN vaccine for mpox works as well in teenagers (ages 12-17) as it does in adults. About 450 healthy participants received two doses of the vaccine. Researchers measured immune responses and monitored for side effects to see if the vaccine is safe…

This early-stage study tested two experimental RSV vaccines given as nose drops in 60 children. Some children already had RSV antibodies (ages 1 to 5) and some did not (ages 6 months to 2 years). The main goal was to check if the vaccines were safe and triggered an immune respons…

This early-stage study tested a new yellow fever vaccine (MVA-BN-YF) in 92 healthy adults aged 18-45. The goal was to check its safety and how well it triggers an immune response, with some groups also receiving an adjuvant to boost effectiveness. Results will help decide if furt…

This early-stage study tested a new DNA-based HIV vaccine in 46 healthy adults without HIV. The vaccine was designed to train the immune system to recognize and fight HIV. Researchers checked for side effects and measured immune responses. The goal was to see if the vaccine is sa…

This early-stage trial tested a new vaccine (CJCV2) against Campylobacter, a common cause of food poisoning. About 60 healthy adults received three different doses of the vaccine, with or without an immune-boosting adjuvant (ALFQ). The main goal was to check safety and see how we…

This early-stage trial tested a new COVID-19 vaccine given as a nasal spray. The goal was to see if it is safe and triggers an immune response. 27 healthy adults aged 18 to 50 received two doses. The vaccine uses a weakened virus to deliver a piece of the COVID-19 spike protein.

This early-stage trial tested a new COVID-19 booster vaccine given as a nasal spray. The goal was to see if it is safe and how well it boosts the immune system. The study involved 60 healthy adults who had already received the standard COVID-19 shots. Researchers monitored side e…

This study tested whether giving smaller doses of the MVA-BN monkeypox vaccine under the skin (instead of the standard full dose into the fat) still provides good protection. About 229 healthy adults aged 18–50 received either one-fifth or one-tenth of the standard dose under the…

This study tested two experimental nasal spray vaccines designed to protect children against human metapneumovirus (HMPV) and parainfluenza virus type 3 (HPIV3), both of which can cause serious breathing problems. Twenty-four children aged 2 to 5 who already had antibodies to HPI…

This study tested updated COVID-19 vaccines designed to protect against new and emerging virus variants. About 1,270 adults who had already been vaccinated received one or two doses of these variant-specific vaccines. The goal was to see how well the updated vaccines boost the im…

This early-stage study tested whether a new vaccine called HSV529 is safe for people. It included 69 healthy adults aged 18 to 40, some with and some without herpes infection. Participants received three shots of the vaccine or a placebo and were monitored for side effects over a…

This study tested an experimental HIV vaccine in 132 healthy adults to see if it is safe and triggers an immune response. Participants received different combinations of the vaccine with or without adjuvants (substances that boost immune response). The goal was to gather early da…

This early-stage study tested an experimental flu vaccine called FluMos-v2 in 30 healthy adults aged 18 to 50. The vaccine is designed to protect against multiple flu strains at once, unlike current shots that target only one or two. Participants received two doses four months ap…

This early-stage study tested a new HIV vaccine called INO-6160 in 20 healthy adults without HIV. The vaccine uses synthetic DNA to teach the body to recognize HIV and includes an immune booster (IL-12). Some participants also received a booster shot with a different HIV protein.…

This study tested a new vaccine designed to stop the malaria parasite from spreading from people to mosquitoes. 105 healthy adults received three doses of the vaccine over a month. The main goal was to check safety and see if the vaccine triggers an immune response. No one was ex…

This study checked the safety of the MVA-BN (Jynneos) vaccine against monkeypox in 500 adults working in high-risk areas of the Democratic Republic of the Congo. Participants received two vaccine doses and were monitored for side effects for up to 28 days after the last dose. The…

This study tested an experimental HIV vaccine in 127 healthy adults who do not have HIV. The main goal was to see if the vaccine is safe and whether it triggers an immune response. Researchers used different combinations of vaccine ingredients and adjuvants (boosters) to find the…

This early-stage study tested a single dose of an experimental mRNA flu vaccine in 50 healthy adults aged 18 to 49. The main goal was to check safety at three different dose levels. A small group also received a standard flu shot for comparison. The study is complete and helps pa…

This study tested a vaccine called Triplex in 90 adults who have both HIV and cytomegalovirus (CMV). The goal was to see if the vaccine is safe and boosts the immune system's ability to fight CMV. Participants received either the vaccine or a placebo, and researchers monitored th…

This early-stage study tested an experimental HIV vaccine in 51 healthy adults to see if it is safe and can trigger an immune response. The vaccine is designed to train the body to make special antibodies that could block HIV. Researchers also tested different combinations of imm…

This study tested a new vaccine designed to prevent Epstein-Barr virus (EBV) infection, which causes mononucleosis and is linked to certain cancers and autoimmune diseases. The trial involved 25 healthy adults aged 18 to 25 who had never had EBV. Participants received either the …

This study tested an experimental vaccine (CssBA+dmLT) to prevent moderate-to-severe diarrhea caused by ETEC bacteria, a common cause of travelers' diarrhea. 72 healthy adults received either the vaccine or a placebo, then were intentionally exposed to the bacteria in a controlle…

This early-stage study tested a new oral vaccine (dmLT) to see if it is safe for people. The vaccine aims to protect against a type of E. coli that causes diarrhea, often called traveler's diarrhea. About 36 healthy adults aged 18-45 received one of four vaccine doses and were mo…

This early-stage study tested a new HIV vaccine in 24 healthy, HIV-negative adults to see if it is safe and can trigger an immune response. The vaccine uses a liposome (a tiny fat bubble) to deliver a piece of the HIV virus. The main goal was to check for side effects and measure…

This study tested a new HIV vaccine called VIR-1388 in 93 healthy adults who did not have HIV. The goal was to see if the vaccine is safe and whether it triggers an immune response. Participants were randomly assigned to receive either the vaccine or a placebo, and researchers mo…

This early-stage study tested a new way to make a flu vaccine that might protect against many different flu strains, not just one. Researchers gave an H5N1 flu shot to 32 adults, some of whom had previously received other experimental flu vaccines. The goal was to see if this 'pr…

This early-stage trial tested a new HIV vaccine candidate in 57 healthy adults without HIV. The vaccine uses a protein designed to train the immune system to recognize HIV. The main goals were to check safety and see if the vaccine triggers a specific immune response. Results wil…

This early-stage study tested two experimental HIV vaccines in 117 healthy, HIV-negative adults to see if they are safe and can trigger an immune response. Participants received several shots of the vaccines, which were designed to train the body to recognize HIV. The main goal w…

This study tested a single dose of a special virus mixture (bacteriophages) given intravenously to adults with cystic fibrosis who have chronic lung infections with Pseudomonas aeruginosa bacteria. The goal was to see if the treatment is safe and can reduce the amount of bacteria…

This study tested whether taking a double dose of the HIV drug dolutegravir (50 mg twice daily) along with the TB drug rifapentine can keep HIV under control in people with both HIV and tuberculosis. Thirty adults with HIV and TB took part. The goal was to see if the higher dose …

This study tested whether the statin drug pitavastatin could lower the risk of heart attacks, strokes, and other serious heart problems in over 7,700 adults with HIV who were already on HIV treatment. Participants were randomly assigned to take either pitavastatin or a placebo pi…

This early-stage study tested a new approach to help kidney transplant recipients stop taking anti-rejection drugs. Eight adults received donor stem cells along with a special drug combination, aiming to train their immune system to accept the new kidney without long-term medicat…

This study tested the safety and tolerability of long-acting injectable HIV medications (cabotegravir and rilpivirine) in 168 children and teens whose HIV was already well-controlled. Participants received oral doses first, then switched to monthly or every-other-month injections…

This study tested whether the drug aviptadil, added to usual care, helps hospitalized COVID-19 patients with severe breathing failure recover better than a placebo. 471 adults took part, and researchers tracked their recovery and safety over 90 days. The goal was to see if avipta…

This study looked at how safe and effective the drug bedaquiline is for children and teens with a hard-to-treat form of tuberculosis (TB) that is resistant to the antibiotic rifampin. The trial included 54 participants, some of whom also had HIV. Researchers monitored side effect…

This study looked at 26 adults with HIV whose virus levels stayed high despite taking combination antiretroviral therapy (ART). Researchers wanted to understand why the drugs weren't working and test ways to improve control, such as directly watching patients take their medicatio…

This study tested whether the drug tecovirimat is safe and effective for treating monkeypox (mpox) in adults and children. Participants received either tecovirimat or a placebo along with standard care for 14 days. The main goal was to see how quickly skin lesions healed. The tri…

This study tested whether a drug called omalizumab can help people with peanut and other food allergies eat small amounts of those foods without having an allergic reaction. The trial included 471 children and adults aged 1 to 55 years. Participants received either omalizumab or …

This early-phase study tested a drug called brentuximab vedotin, originally used for lymphoma, in 17 people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The main goal was to see if the drug is safe and tolerable. Researchers monitored for serious side…

This study looked at 48 kidney and liver transplant recipients who had a weak antibody response after their initial COVID-19 vaccines. Researchers gave everyone an extra mRNA booster shot and randomly assigned some to temporarily reduce their immunosuppressive medications. The go…

This study tested two different doses of the drug linezolid, combined with three other medicines, to treat drug-resistant tuberculosis (TB). The goal was to see if a lower dose could work just as well but with fewer side effects. 138 adults with drug-resistant TB took part. The r…

This study tested whether giving two lab-made antibodies (VRC01LS and 10-1074) could keep HIV suppressed in 30 children in Botswana who started HIV treatment very early. The children stopped their regular HIV pills and received antibody infusions instead. The goal was to see if t…

This study tested whether the drug remdesivir helps hospitalized COVID-19 patients with severe breathing problems recover better than standard care alone. About 87 adults took part, receiving either remdesivir or a placebo plus usual treatments. The main goal was to see how well …

This study tested an oral drug called selgantolimod in 29 adults who have both chronic hepatitis B and HIV and have been on stable antiviral therapy for at least 5 years. The goal was to see if the drug is safe and can lower hepatitis B surface antigen (HBsAg) levels in the blood…

This study tested the safety of tofacitinib, a drug already used for arthritis, in 10 adults with chronic granulomatous disease (CGD) who had ongoing inflammatory problems in the gut, skin, or lungs. Participants took the pill for 3 months while doctors monitored side effects and…

This early-stage study tested an experimental antibody called VRC01 in 24 adults with very recent HIV infection. The goal was to see if it is safe and can lower the amount of virus in the blood, either alone or with standard HIV medications. The study found that VRC01 was general…

This early-phase study tested whether rituximab, a drug that targets certain white blood cells, is safe for people with rare diseases where the body's immune system attacks its own proteins. Seven adults with conditions like pulmonary alveolar proteinosis or severe candidiasis re…

This study tested a drug called AMG 714 in 60 adults with vitiligo, a condition that causes white patches on the skin. The goal was to see if the drug could help bring back skin color on the face after 24 weeks of treatment. Participants received either the drug or a placebo, and…

This study tested the safety and effectiveness of the drug tecovirimat for treating mpox (formerly monkeypox) in 328 adults and children. Participants received either tecovirimat or a placebo, and researchers measured how quickly their skin lesions healed. The trial also tracked …

This study tested whether adding tocilizumab to standard anti-rejection medicines helps heart transplant recipients have better outcomes one year after surgery. Researchers looked at whether the drug reduced rejection, harmful antibodies, and improved heart function. The trial in…

This large, international study aimed to find safe and effective treatments for people hospitalized with COVID-19 who developed severe breathing failure. It tested several investigational drugs, including aviptadil and remdesivir, by adding them to the standard hospital care pati…

This study tested whether a simple saltwater mouth rinse can detect pneumocystis, a lung infection that can be life-threatening for people with weak immune systems (like those with HIV, cancer, or organ transplants). Current diagnosis requires coughing up lung fluid or a tube ins…

This study tested a single injection of a lab-made antibody called L9LS in healthy Kenyan children aged 5 months to 10 years. The goal was to see if it is safe and can protect against malaria caused by the Plasmodium falciparum parasite. Over 900 children took part, and researche…

This early-stage study tested a vaginal ring that slowly releases the HIV drug tenofovir over 90 days. The goal was to see if the ring is safe and delivers enough drug to prevent HIV. 49 healthy women took part, and researchers measured drug levels in blood, vaginal fluid, and ti…

This large study tested whether a long-acting injectable drug (cabotegravir) could prevent HIV infection better than daily oral pills in men and transgender women who have sex with men and are at high risk. Over 4,500 participants received either the injection every 8 weeks or a …

This study looked at whether a dengue vaccine (TV003) or a past Zika infection could protect people from getting Zika again. 27 healthy adults were given the vaccine or had a prior Zika infection, then were exposed to the Zika virus to see if they got infected. The goal is to fin…

This study tested a clever way to prevent dengue fever: releasing mosquitoes infected with Wolbachia bacteria into neighborhoods. These special mosquitoes make it harder for viruses like dengue to spread. Over 5,700 children in Brazil took part, and the approach was added to stan…

This early-stage study tested a new lab-made antibody called CAP256J3LS in 24 healthy adults to see if it is safe and how long it stays in the body. The antibody is designed to stop HIV from infecting cells. Participants received either one or three doses by injection or IV, and …

This study looked at whether a special liquid diet (elemental diet) can change gut bacteria and improve stomach and bowel symptoms in people with chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD). Three participants aged 8 to 65 followed the diet for up to …

This study tested a drug called JBT-101 (lenabasum) in 109 adults with lupus who had active joint pain. Participants took the drug or a placebo by mouth for 84 days. The main goal was to see if the drug could reduce daily pain levels. The approach uses the body's natural processe…

This study tested whether taking a grass pollen tablet under the tongue along with the drug dupilumab for 2 years could help adults with moderate to severe seasonal allergies tolerate grass pollen better. About 199 participants were involved. The main goal was to see if this comb…

This early-stage study tested a single dose of an experimental drug called SAR440894 in 42 healthy adults aged 18 to 45. The main goal was to check if the drug is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo, and …

This study looked at liver damage in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Researchers used liver biopsies, ultrasound, and CT scans to check for scarring (fibrosis) and fat buildup. The goal was to better understand how HIV drugs may harm t…

This study looked at how HIV and tuberculosis medications are processed in the bodies of pregnant women and new mothers. Over 1,500 participants provided blood samples to measure drug levels during pregnancy and after childbirth. The goal was to find the right doses to keep both …

This study followed 1,377 people living with HIV in Liberia over about 3 years. Researchers collected health data, blood and urine samples, and asked questions about symptoms and behaviors. The goal was to better understand how HIV affects people in Liberia and to help improve lo…

This study tested a special method called xenodiagnosis to see if Lyme disease bacteria can survive antibiotic treatment. Researchers placed clean ticks on the skin of 45 people who had or never had Lyme disease. The ticks were later checked for the bacteria. The goal was to unde…

This study explored how malnutrition, diabetes, and worm infections influence the body's response to latent tuberculosis (LTBI) in 626 people aged 14–65 in South India. Participants provided blood, urine, and stool samples, and some had chest X-rays or ultrasounds. The goal was t…

This study looked at whether people who had a bone marrow transplant would do a better job of monitoring for cytomegalovirus (CMV) if they could test themselves at home using a finger-prick blood spot and get reminders on a mobile device. About 150 transplant recipients took part…

This study followed 775 healthy children aged 2-9 in Cambodia for three years to learn how mosquitoes spread dengue and other viruses. Researchers took blood samples each wet and dry season to check for infections and mosquito exposure. The goal was to gather information to help …

This study collected blood samples from 310 HIV-infected adults and healthy volunteers to measure markers of inflammation, blood clotting, and blood vessel function. The goal was to better understand how these markers relate to HIV and risks like heart disease or stroke. No treat…

This study looked at the genes in the skin of 433 people with eczema (atopic dermatitis) to find patterns that separate mild from severe disease. Researchers also checked how standard treatments like steroid creams and dupilumab change those gene patterns over time. The goal was …

This study tested how bismuth subsalicylate (the active ingredient in Pepto-Bismol) affects the bacteria living in the gut. 34 healthy adults took the medicine for 2 days, and researchers compared their stool samples before and after. The goal was to understand how this common st…

This study looked at how a tuberculosis drug called pretomanid is handled by the body in people with different levels of kidney function. Researchers gave a single dose to 12 adults, including those with severe, mild, or moderate kidney impairment and healthy volunteers. The goal…

This study involved 90 Ugandan children aged 6 months to 14 years with severe malaria. Researchers gave them standard IV artesunate and measured how the drug affected their body functions and cleared the parasite. The goal was to learn more about the right dose, not to test a new…

This study looked at 90 adults with HIV in Uganda whose virus is well-controlled by medication. Researchers measured the hidden HIV that stays in the body (the latent reservoir) and compared it to similar patients in the U.S. The goal was to learn more about this reservoir to hel…

This study collected blood, saliva, stool, urine, and skin samples from 19 people aged 2 and older with known or suspected immune defects. The goal was to learn how different parts of the immune system work together, not to test a treatment. Participants were followed for up to 5…

This study looked at why some people get hives from physical triggers like cold, pressure, or exercise. Researchers tested 173 participants to confirm their triggers and collected blood and skin samples to study immune system activity and genetic factors. The goal was to better u…

This study gave 32 healthy adults a mild dose of respiratory syncytial virus (RSV) in a hospital setting to closely monitor how the body fights the infection. Participants stayed in isolation for about 10 days while researchers tracked symptoms, viral shedding, and immune respons…

This study looked at how well different COVID-19 vaccines work in adults from 7 countries. About 5,400 people joined within a day of getting their vaccine. Researchers measured immune responses and tracked any side effects to understand how the vaccines protect against COVID-19.

This study looked at 190 HIV-positive women starting HIV medication to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track viral shedding and inflammation. The goal was to understand why some women …

This study looked back at medical records of 137 people with chronic granulomatous disease (CGD), a rare immune disorder. Researchers compared those who had a stem cell transplant with those who received standard care to see who lived longer and had fewer infections. The goal was…

This study investigated whether measles infection can cause 'immune amnesia'—temporarily wiping out a child's existing immunity to other diseases. Researchers followed 264 children aged 1-15 in Africa, comparing those with and without measles. They measured antibody levels and re…

This study looked at tissue samples from tonsils, lymph nodes, intestines, and lungs of people with HIV and healthy volunteers. The goal was to measure virus levels and immune cells to better understand how HIV behaves in the body during treatment. About 386 adults took part, and…

This study looked at how children's immune systems respond to the flu vaccine. Researchers collected nasal and finger-prick blood samples from 65 kids aged 2-17 before and after they got their regular flu shot. The goal was to understand both nose and body-wide immunity to help d…

This study aimed to measure how common malaria and worm infections are in pregnant women and children in two counties of Liberia. Over 1,200 participants gave a small blood sample and answered health questions. The results help doctors understand the local disease burden and impr…

This completed study looked at how HIV and tuberculosis medications behave in the bodies of pregnant women and new mothers. Researchers measured drug levels in 205 women during pregnancy and after delivery to find the right doses. The goal was to make sure both mother and baby ge…

This study followed nearly 1,000 people with severe allergic conditions like eczema and related genetic disorders to understand how these diseases develop and change over time. Participants, including children and adults, underwent tests such as allergy skin pricks, blood draws, …

This study looked at how the virus that causes COVID-19 reduces the number of lymphocytes—a type of white blood cell that fights infections—in the blood. Researchers studied 240 adults who currently had COVID-19 or had recently recovered. They collected blood samples and medical …

This early-stage study tested a new drug called EV68-228-N in 36 healthy adults to see if it is safe and how the body processes it. Participants received a single dose of the drug or a placebo by IV. The main goal was to check for side effects, not to treat any disease. This rese…

This study aims to find genetic mutations that cause severe allergic conditions like asthma, eczema, food allergies, and anaphylaxis. Up to 1,000 people (patients and their relatives) aged 1 to 80 will provide blood samples and answer questionnaires. No treatment is given; the go…

This study looked at how two common antibiotics (amoxicillin and azithromycin) change the community of microbes living in healthy people, and whether those changes affect metabolism and the immune system. Over 100 healthy adults took antibiotics for a week or less, and researcher…

This study aimed to measure how often people of all ages in Sabou, Burkina Faso, get malaria over one year. Researchers tracked infections in 608 healthy volunteers aged 6 months to 65 years through monthly blood tests and surveys. The information gathered will help design better…

This study tested an oral herpes drug, valacyclovir, in 17 newborns whose mothers had genital herpes. The goal was to find a dose that gives the same drug levels in the blood as the standard IV treatment. The results help doctors know how to safely give this medicine by mouth to …