Transplant patients get stronger COVID protection by temporarily lowering immune drugs

NCT ID NCT05077254

First seen Jan 11, 2026 · Last updated May 17, 2026 · Updated 15 times

Summary

This study looked at 48 kidney and liver transplant recipients who had a weak antibody response after their initial COVID-19 vaccines. Researchers gave them an extra mRNA booster shot, and in some patients they temporarily reduced immune-suppressing medications to see if that would improve antibody levels. The goal was to find a safer way to boost protection against severe COVID-19 in this high-risk group.

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Contacts and locations

Locations

  • Emory Healthcare

    Atlanta, Georgia, 30322, United States

  • Houston Methodist

    Houston, Texas, 77030, United States

  • Johns Hopkins Institute for Clinical and Translational Research: Broadway Adult Outpatient Clinical Research Unit

    Baltimore, Maryland, 21287, United States

  • Mt. Sinai Hospital

    New York, New York, 10029, United States

  • NYU Langone Transplant Institute

    New York, New York, 10016, United States

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Ochsner Health

    New Orleans, Louisiana, 70121, United States

  • University of California San Francisco Health

    San Francisco, California, 94143, United States

  • University of California, San Diego

    San Diego, California, 92093, United States

  • University of Illinois Health

    Chicago, Illinois, 60612, United States

  • University of Iowa Hospitals

    Iowa City, Iowa, 52242, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15260, United States

  • University of Wisconsin-Madison

    Madison, Wisconsin, 53706, United States

  • Weill Cornell Medicine

    New York, New York, 10065, United States

Conditions

Explore the condition pages connected to this study.