New drug combo could slash kidney transplant wait times for Hard-to-Match patients

NCT ID NCT04827979

First seen Jan 23, 2026 · Last updated May 16, 2026 · Updated 20 times

Summary

This study tests whether two drugs, daratumumab and belatacept, can lower immune sensitivity in kidney transplant candidates who are highly sensitized, meaning their bodies reject most donor kidneys. Nineteen participants with very high antibody levels receive the drugs to see if they become compatible with more donors. The goal is to help them get a transplant sooner and reduce the risk of rejection.

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Contacts and locations

Locations

  • University of California at San Francisco Medical Center

    San Francisco, California, 94143, United States

Conditions

Explore the condition pages connected to this study.