New drug combo may unlock transplants for 'Impossible-to-Match' kidney patients

This study tests whether two drugs, daratumumab and belatacept, can lower the immune system's sensitivity in kidney transplant candidates who are very hard to match. About 19 highly sensitized patients will receive the treatment to see if it reduces their antibody levels or allows them to receive a kidney from a previously incompatible donor. The goal is to shorten their wait time and increase their chance of getting a transplant.