Could antibody shots replace daily HIV pills for kids?

NCT ID NCT03707977

Completed Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether two lab-made antibodies, VRC01LS and 10-1074, could keep HIV under control in 30 children in Botswana who started treatment early. The children received the antibodies by infusion and stopped their regular HIV medication. Researchers monitored how many kids maintained low virus levels and tracked any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: VRC01LS and 10-1074 (broadly neutralizing antibodies)
What this could lead to: If successful, this could point toward a way for children with HIV to maintain viral suppression without daily antiretroviral therapy.
What could go wrong: This is an early-phase study with only 30 children, so results may not apply widely. The antibodies may not keep HIV suppressed in all children, and there is a risk of side effects from the infusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HIV INFECTION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTION

Contacts and locations

Locations

Botswana Harvard AIDS Institute Partnership CRS Non-Network

Gaborone, Botswana
Francistown Non-Network CRS

Francistown, Botswana

More trials for these conditions

Other studies related to the condition(s) this trial covers.