HIV INFECTION

This study tests whether giving very early and intensive HIV medicines, with or without an extra antibody, can help babies control the virus without needing lifelong daily drugs. Researchers will enroll over 1,100 infants born with HIV and monitor them closely. The goal is to see…

This study compares heart transplants from HIV-positive and HIV-negative donors in 50 HIV-positive patients with advanced heart failure. The goal is to see if using HIV-positive donor hearts is as safe and effective. Participants receive whichever donor heart becomes available fi…

This study is testing whether a smartphone app called Positively Smoke Free - Mobile can help people living with HIV quit smoking. Participants will also receive a low-dose CT scan to screen for lung cancer. The goal is to see if using the app at the time of screening is practica…

This phase 1 trial is testing a CAR-T cell therapy (axicabtagene ciloleucel) in 20 adults with HIV and aggressive B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to recognize and attack cancer c…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and reach undetectable viral loads. About 716 men will take part and be followed for 12 month…

This early-stage study tests a new experimental drug, MK-4646, in 28 people with HIV-1 who have never taken HIV medication. The main goals are to see if the drug is safe and tolerable, and how much it can lower the amount of virus in the blood. Participants will take the drug alo…

This study tests whether taking 75 mg of zinc daily can improve immune function in people with HIV whose CD4 counts remain low despite antiretroviral therapy. About 120 participants will be randomly assigned to receive zinc or continue their usual care. The goal is to see if zinc…

This study is checking if a new finger-prick test for HIV and syphilis is easy and accurate enough for people to use on themselves at home. About 900 adults in Canada will try the test and compare results with standard lab tests. The study also looks at how peer support can help …

This study tests whether offering HIV prevention medication (PrEP) on a medical van is a good way to reach people who inject drugs or are sexually active. About 20 adults at high risk for HIV will receive PrEP and be followed for 6 months. The goal is to see if this approach help…

This study follows 450 HIV-positive people who can keep the virus under control without taking antiretroviral drugs. Researchers want to understand how their immune systems do this and what happens over time. The goal is to learn more about the body's natural defenses against HIV…

This study looks at immune cells in the gut, spinal fluid, lymph nodes, and blood of HIV-positive and HIV-negative adults in Thailand. Researchers want to understand how HIV changes the immune system in different parts of the body. About 232 people aged 18 to 50 will join. This i…

This study tests whether setting up special HIV teams in hospitals can help find undiagnosed HIV in patients who have conditions linked to HIV. About 5,200 patients across ten European countries will be included. The teams will review medical records, remind doctors to offer HIV …