HIV INFECTION

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This study tests a new oral cholera vaccine (Biovac OCV-S) to see if it works as well as a currently approved vaccine (Euvichol-Plus). About 2,824 healthy people aged 1 to 45, including some adults living with HIV, will receive two doses. Researchers will check immune responses a…

This trial tests whether a two-drug combination (darunavir/cobicistat plus lamivudine) works as well as a standard three-drug combination (darunavir/cobicistat plus tenofovir alafenamide/emtricitabine) in people with HIV whose virus is already suppressed. The study involves 78 ad…

This study tests whether a simple text-message system can help caregivers in Kenya spot and prevent malnutrition in children exposed to HIV. About 776 caregiver-child pairs will be split into two groups: one gets weekly SMS reminders to measure the child's arm and receive feeding…

This study tests whether giving very early and intensive antiretroviral therapy, plus an antibody, can help infants with HIV achieve remission—meaning the virus stays undetectable even after stopping treatment. Researchers will enroll about 1,120 infants and follow them for safet…

This study tests whether adding the HIV drug rilpivirine to standard treatment can help people with HIV whose immune systems haven't fully recovered. About 21 adults with low CD4 counts despite years of successful viral suppression will receive rilpivirine for 48 weeks. The goal …

This study is testing whether a smartphone app designed for people with HIV can help them quit smoking when combined with a lung cancer screening CT scan. About 100 participants will use the app and get a low-dose CT scan. The goal is to see if this approach is practical and help…

This study tests a program called Full-SPARCS, where trained peers lead group sessions to help people with HIV stay in care after they leave prison in South Africa. The program includes one-on-one check-ins and group meetings in community centers. Researchers will compare viral s…

This study tests a program called ARC that helps HIV clinics improve their work environment and reduce discrimination. Researchers will compare viral suppression and care retention in clinics using ARC versus standard care. The goal is to see if better clinic culture leads to bet…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different co…

This study tests whether personalized text messages can help HIV-positive women in Africa who sell sex take their antiretroviral therapy (ART) regularly. 350 women will either get standard care or standard care plus text reminders and tips for six months. The goal is to see if mo…

This study tests a lab-made human protein called CYT107 in 55 people with HIV and Kaposi sarcoma. The protein aims to boost T cells, which may help shrink cancer tumors. Participants receive weekly injections for up to 4 weeks, with follow-up for 3 years.

This study tests whether adding one dose of a stronger antifungal drug (liposomal amphotericin) to the standard treatment (fluconazole) can prevent cryptococcal meningitis in HIV-positive adults who test positive for the fungus but have no symptoms. About 356 participants in Ugan…

This study tests whether high-dose zinc supplements can improve immune function in people with HIV who still have low CD4 counts despite successful antiretroviral therapy. 120 participants will receive either zinc or a placebo for 16 weeks. Researchers will measure changes in CD4…

This study tests a CAR-T cell therapy (axicabtagene ciloleucel) in 20 HIV-positive adults whose aggressive B-cell lymphoma has come back or stopped responding to standard treatment. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells. The …

This study tests a couple-based problem-solving therapy for pregnant women living with HIV who also have depression. The goal is to improve their mental health and help them stick to their HIV medication, which prevents passing the virus to their baby. The trial will enroll 180 c…

This study tests a program called reSTART for men living with HIV who also use stimulants. It combines a smartphone app, a urine test to check medication levels, and motivational messages to help them remember to take their HIV drugs. The goal is to see if this approach can lower…

This study tests a system that uses a special pill bottle to track when HIV medication is taken. If doses are missed, the system alerts a care team to help address problems like food or housing issues. The goal is to help 110 adults in Los Angeles stick to their HIV treatment and…

This study tests two ways to help Latino men with HIV take their medication regularly. One group gets text reminders, and the other gets texts plus online support from a navigator. The goal is to see which approach works better for keeping the virus under control. 250 men will pa…

This study is testing a mobile health app designed to help women living with HIV remember their medications, appointments, and prescription refills. The app also addresses barriers like stigma and mistrust of the medical system. Researchers will enroll 80 women to see if the app …

This study looks at whether hearts from HIV-positive deceased donors are as safe and effective for HIV-positive recipients as hearts from HIV-negative donors. Fifty HIV-positive patients with advanced heart failure will receive a heart transplant, with the donor's HIV status dete…

This study tests a program called ADELANTE for Latinos with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the health worker progra…

This study tests whether teaching pregnant women in Kenya how to farm and providing them with supplies like seeds and irrigation pumps can reduce food shortages and improve health for both mothers and their babies. 410 pregnant women, half living with HIV, will be randomly assign…

This study tests whether daily text reminders and small prize incentives can help people with HIV take their medication on time every day. Researchers will enroll 550 adults in Uganda who recently started HIV treatment. Participants will receive text messages linking pill-taking …

This study investigates whether urine samples can be used to screen for cervical cancer in women living with HIV. Researchers will compare the accuracy of urine HPV testing with self-collected and provider-collected samples to detect cervical precancer (CIN2 or worse). The goal i…

This study is testing a new medical device called MagIA IBC that uses a single drop of blood from a finger prick to screen for HIV, hepatitis B, and hepatitis C at the same time. Researchers will enroll 252 adults who are known or suspected to have one of these infections. The go…

This study checks if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results to lab tests. The study also looks at how peer support can help homeless people in Toronto get tested and tre…

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. One hundred participants will either receive the shot or standard harm reduction supplies. R…

This study tests a program called Treat4All that helps people who drink heavily and are at risk for HIV or already have HIV. About 160 adults from an STI clinic in Lilongwe, Malawi, will either get the program or usual care. The goal is to see if the program reduces heavy drinkin…

This study tests whether giving HIV prevention pills (PrEP) on a medical van is a good way to reach people who inject drugs and are at high risk for HIV. The researchers will enroll 20 adults who use drugs or are sexually active and see how many start and stay on PrEP. The goal i…

This study looks at whether hormone therapy (estrogen with or without progesterone) can safely reduce hot flashes and night sweats in women living with HIV. Researchers will also check if it improves sleep, mood, thinking, bone health, and quality of life. About 105 women aged 40…

This study tests a digital peer-support program to reduce HIV-related stigma in 282 adolescents aged 15–22 in Ethiopia. Participants will use a phone-based group to share experiences and support each other, aiming to improve their mental well-being and help them stay in care. The…

This study reviews medical records of over 5,600 people with HIV to see how many might need special dental care due to low immune cells or blood issues. The goal is to help dentists know when to take extra steps and when standard care is safe, reducing stigma. It is an observatio…

This study will screen 2,000 people with HIV for fatty liver disease using a painless ultrasound technique. The goal is to catch liver problems early and improve long-term care. Researchers will also track how different HIV medications affect liver health.

This study looks at why some people with HIV develop Immune Reconstitution Inflammatory Syndrome (IRIS) after starting HIV medications. Researchers will use PET scans and lymph node biopsies to track inflammation and immune recovery in 300 adults. The goal is to better understand…

This study looks at whether a prebiotic supplement can help repair the gut barrier and reduce inflammation in people with HIV who also have alcohol use disorder. Forty participants will take either a prebiotic or a placebo for four weeks, then switch. Researchers will measure gut…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…

This study is testing whether the antibiotic doxycycline, already used to prevent bacterial STIs after sex, also changes inflammation levels and the natural bacteria in the body. Researchers will enroll 200 men, including those with HIV and those on PrEP, and measure immune marke…

This study looks at immune cells in the gut, spinal fluid, lymph nodes, and blood of HIV-positive and HIV-negative adults in Thailand. The goal is to understand how HIV changes the immune system in different parts of the body. About 232 people aged 18 to 50 will join. No new trea…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study follows 450 HIV-positive adults in France who can naturally control the virus without taking antiretroviral drugs. Researchers want to understand how their immune systems keep the virus in check and why some eventually lose that control. The goal is to learn more about…

This study looks at how common certain infections are among 250 asylum seekers living in reception centers in Italy. Participants must be adults who arrived in Italy between 2 and 36 months ago. The goal is to better understand infection rates to improve health screening and care…

This study looks at whether it's practical to surgically remove a type of eye surface tumor (OSSN) in people living with HIV in Sub-Saharan Africa. About 84 participants will have the tumor cut out and be followed for a year to see if the procedure is safe and if patients return …

This study is testing whether setting up special HIV teams in hospitals can increase testing for undiagnosed HIV. The teams will remind doctors to test patients with certain health conditions, reduce stigma, and improve care links. Over 5,200 patients across ten European countrie…

This study is testing whether people with HIV can collect small blood samples at home using a finger prick or a simple device. The goal is to see if these home-collected samples are as good as clinic-drawn blood for measuring levels of HIV medications. About 150 adults already on…

This study pauses HIV medication in 40 volunteers to closely monitor how the virus and body interact during the earliest stages of rebound. Participants stop their antiretroviral therapy and undergo frequent testing, resuming treatment within three weeks. The goal is to learn mor…

This study looks at whether peer education and support can help more adolescents and young adults (ages 15-39) living with HIV get screened for cancer and stick with their cancer treatment. Researchers will work with 4,100 participants in Zambia to improve early diagnosis and tre…

This study looks at whether people with HIV have chronic pain because their bodies don't make enough natural painkillers (opioid peptides). Researchers will test pain sensitivity in 200 adults (with and without HIV) using heat, touch, and pressure. The goal is to understand the c…

This study looks at whether people living with HIV can collect their own anal swab to test for HPV (a virus that can cause anal cancer) as accurately as a doctor can. About 400 adults aged 30 and older in Reunion Island will try both methods and share which they prefer. The goal …

This study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using b…