Can one Mega-Dose of an antifungal beat a deadly infection in AIDS patients?

NCT ID NCT05814432

Recruiting now Disease control Sponsor: Federal University of Health Science of Porto Alegre Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This phase III trial is testing whether a single high dose (10 mg/kg) of liposomal amphotericin B can safely and effectively treat disseminated histoplasmosis, a serious fungal infection, in adults with AIDS. The standard treatment requires two weeks of daily infusions. The study compares the single-dose approach to the standard regimen, measuring survival and side effects. If successful, it could simplify treatment and reduce hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a single high dose of liposomal amphotericin B
What this could lead to: If it works, a single high dose could replace the current two-week standard treatment, making therapy simpler and faster for a deadly fungal infection in people with AIDS.
What could go wrong: This is an early-phase trial, so the high dose may cause more side effects like kidney problems or electrolyte imbalances, and it might not be as effective as the standard regimen.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AIDS fungal infectious disease histoplasmosis HIV infectious disease Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AIDS AND INFECTIONS DISSEMINATED HISTOPLASMA CAPSULATUM INFECTION FUNGAL INFECTION IMMUNOSUPPRESSION

Contacts and locations

Locations

Federal University of Health Sciences of Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Hospital Geral de Roraima
RECRUITING

Boa Vista, Roraima, Brazil
Hospital Giselda Trigueiro
RECRUITING

Natal, Rio Grande do Norte, Brazil
Hospital de Clinicas de Porto Alegre
RECRUITING

Porto Alegre, Rio Grande do Sul, Brazil
Hospital de Doenças Tropicais
RECRUITING

Goiânia, Goiás, Brazil

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