IMMUNOSUPPRESSION

This study tests whether giving immunosuppressive drugs as a single daily dose after liver transplant works as well as the standard twice-daily regimen. About 162 adult liver transplant recipients will be randomly assigned to once-daily or twice-daily dosing. The goal is to see i…

This study tests hand transplantation for people who have lost a limb below the elbow. The goal is to see if the transplanted hand can be used for daily activities 18 months after surgery. Participants must be 18-65 and willing to travel for regular check-ups, blood tests, and bi…

This study tests whether checking a patient's genes before a kidney transplant helps doctors give the right dose of tacrolimus, a drug that prevents organ rejection. About 114 people waiting for a kidney transplant will be randomly assigned to either genetic testing or standard c…

After a liver transplant, patients must take lifelong anti-rejection drugs that can cause kidney problems, diabetes, heart disease, and cancer. This study tests whether a simple ultrasound-like test called a fibroscan can identify patients who can safely reduce their anti-rejecti…

This early-stage study tests whether a robotic bladder transplant from a deceased donor can work for 5 people with severe bladder damage. The goal is to see if the new bladder gets good blood flow and works better than current treatments using bowel tissue. Participants must be w…

This study compares two treatments for children aged 6-18 with Crohn's disease: one group gets infliximab alone, another gets immunosuppressives alone, and a third gets both. The goal is to see which approach leads to more kids achieving remission (symptom-free and healed gut) af…

This study looks at how transplant patients, who take drugs to suppress their immune system, respond to the shingles vaccine compared to their healthy housemates. Researchers will give 160 participants two doses of the SHINGRIX vaccine and measure their immune responses over one …

This study looks at how problems with the immune system can lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from people with genetic immune defects, healthy people with gum disease, and healthy people without gum disease…

This observational study looks at how severe trauma changes the body's blood and bone marrow, aiming to understand why some patients become immune-suppressed and develop infections like sepsis. Researchers will collect blood and bone marrow samples from 255 trauma patients and co…