A One-Two punch against cervical cancer: testing plus vaccination in HIV-Positive women
NCT ID NCT06402383
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests two strategies for preventing cervical cancer in women living with HIV in Tanzania. Both strategies involve HPV self-sampling and visual checks of the cervix, but they differ in the timing of HPV vaccination. The study aims to see which approach better reduces precancerous lesions at a 12-month follow-up, potentially informing national screening programs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HPV vaccine (offered alongside HPV DNA testing and visual assessment of the cervix)
- What this could lead to
- If successful, this could establish a practical, effective strategy for preventing cervical cancer in women living with HIV, potentially reducing cervical cancer rates in Tanzania and similar settings.
- What could go wrong
- The trial is early-stage and may face challenges in implementation, such as adherence to follow-up visits. The vaccine's benefit in women already exposed to HPV is uncertain, and outcomes may not generalize beyond the study population.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pamoja Tunaweza Women's Centre
Moshi, Tanzania
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