HIV INFECTION

This study tested four different combinations of experimental HIV vaccines in healthy volunteers at low risk of infection. The main goals were to see if the vaccines were safe and if they could trigger an immune response against HIV. Researchers compared different orders and type…

This study tested if people with well-controlled HIV could safely switch from a standard three-drug daily pill to a new two-drug daily pill. Researchers compared the new combination (doravirine/islatravir) against continuing the original treatment to see if it kept the virus supp…

This study tested whether people who got an experimental antibody (VRC01) before catching HIV could better control the virus without daily medication. 13 participants who started HIV treatment early stopped their pills under very close medical monitoring. Researchers watched to s…

This study tested if people with HIV who were already successfully controlling their virus could safely switch to a new, simpler once-daily pill (doravirine/islatravir). It compared this new combination to people who continued their current antiretroviral therapy. The main goal w…

This study tested a new dose of three proven HIV medicines (dolutegravir, emtricitabine, and tenofovir alafenamide) in children under 10 years old in Africa. The goal was to find the right dose to create a single, easy-to-take tablet that works for all children, just like adults.…

This study tested whether a 12-week, high-intensity exercise program delivered by video could slow down the accelerated aging process seen in older Veterans living with HIV. Researchers enrolled 89 Veterans over age 50 with stable HIV to see if the no-equipment circuit training c…

This study tested whether the HPV vaccine could help prevent high-grade cervical lesions from developing or returning in women living with HIV. 536 HIV-positive women who also had HPV received either the actual vaccine or a placebo (saltwater shot) after their cervical lesions we…

This study tested whether a personal support guide could help men in Malawi continue taking HIV prevention medication (PrEP) for at least six months. The program was offered to 199 heterosexual men who visited a clinic for sexually transmitted infections. Researchers compared how…

This study is observing children who started HIV medication within weeks of birth to understand their long-term health, immune system, and virus levels. About 250 children will be followed for up to seven years with regular check-ups and sample collection. The goal is to gather d…

This study aimed to understand how the body's own immune system might be involved in causing or worsening pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers compared blood samples from over 600 people, including patients wi…

This study aimed to understand if HIV infection causes hidden problems with how the kidneys process water, even when standard blood and urine tests appear normal. Researchers compared 30 adults with HIV to people without HIV using a special kidney function test. The goal was to g…