HIV INFECTION

This study tested whether a double-dose hepatitis B vaccine (40 micrograms) works better than the standard dose (20 micrograms) in people with HIV who had not responded to previous hepatitis B vaccines. The trial included 178 participants and measured how many developed protectiv…

This study tested four different HIV vaccine combinations in 92 healthy volunteers at low risk of HIV. The goal was to find which combination is safest and best at triggering the body's immune system to fight HIV. Researchers used a prime-boost approach, giving one vaccine first …

This study looked at how the HIV medicine raltegravir works in people with severe liver failure who need a liver transplant. It included 14 HIV-positive adults with end-stage liver disease. Researchers measured how the drug behaves in the body and checked for interactions with an…

This study tested whether the HPV vaccine can reduce the chance of developing high-grade cervical lesions (precancerous changes) in women living with HIV. About 536 women received either the HPV vaccine or a placebo. The goal was to see if the vaccine helps the immune system figh…

This study looked at whether people with HIV whose virus is already well-controlled can safely lower their daily dose of the drug darunavir from 800 mg to 400 mg. About 100 adults with stable HIV took part. The goal was to see if the lower dose could still keep the virus level un…

This study tested whether switching to a two-drug pill (doravirine/islatravir) works as well as staying on a three-drug pill (BIC/FTC/TAF) for people whose HIV is already suppressed. About 643 adults with HIV took part. The main goal was to see if the new pill kept virus levels l…

This study looked at whether switching to a new once-daily pill (doravirine/islatravir) is safe and effective for people with HIV whose virus is already suppressed by their current medication. Over 600 adults took part. The main goal was to see if the new pill kept the virus unde…

This study tested whether a new combination of three HIV medicines (dolutegravir, emtricitabine, and tenofovir alafenamide) at a special dose works well and is safe for children living with HIV in Africa. 53 children aged 28 days to 10 years took part. The goal is to create a sin…

This study tested whether giving two lab-made antibodies (VRC01LS and 10-1074) could keep HIV suppressed in 30 children in Botswana who started HIV treatment very early. The children stopped their regular HIV pills and received antibody infusions instead. The goal was to see if t…

This study tested whether adding the drug maraviroc to standard HIV treatment for 24 weeks could improve immune function in people whose CD4 counts stayed low even though their HIV was well-controlled. The trial included 60 HIV-positive adults with CD4 counts below 350 and little…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for radiation or chemotherapy. Sixteen participants were followed for …

This study tested a 12-week course of telaprevir added to a longer course of peginterferon and ribavirin in 70 adults with both HIV and hepatitis C who had not been helped by earlier treatment. The goal was to see if this combination could clear the hepatitis C virus for good. Th…

This study looked at whether low-dose CT scans can help find lung cancer early in people with HIV who have a history of heavy smoking. About 450 participants aged 40 and older were scanned. The goal was to measure how many lung cancers were found and to learn more about the types…

This study tested a new lab-made antibody called CAP256J3LS in 24 healthy adults to see if it is safe. The antibody is designed to stop HIV from infecting cells. Participants received either one or three doses by injection or IV, and were monitored for side effects over several m…

This large study in South Africa tested whether offering HIV treatment immediately after diagnosis, instead of waiting until the patient's immune system weakens, could reduce the number of new HIV infections in entire communities. Over 28,000 people from 22 different areas took p…

This study tested a program to prevent HIV in men who have sex with men in sub-Saharan Africa. Over 800 men received check-ups, STI tests, counseling, and condoms every three months. The goal was to see if this regular care is practical and helps lower HIV infections in this grou…

This study tested whether a personal helper (a systems navigator) could help heterosexual men in Malawi keep taking HIV prevention medicine (PrEP) after visiting a clinic for a sexually transmitted infection. About 199 men took part. The navigator provided support and reminders t…

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 HIV-positive veterans aged 50 and older. Participants did circuit training combining resistance and aerobic exercises, available via video conferencing. The goal was…

This study followed 516 HIV-positive men who have sex with men over time to track anal HPV infection and related cell changes. Researchers used exams and anal swabs to see how often high-grade lesions appear or go away on their own. The goal was to gather information that could h…

This study looked at whether a specific genetic change in the TLR7 gene (found on the X chromosome) is more common in women with HIV than in healthy women. The goal was to understand if this gene change makes it harder for the immune system to fight off HIV. Researchers studied 9…

This study looked at 30 people with HIV who had undetectable virus levels in their blood for at least 6 months due to antiretroviral therapy. Researchers examined gut tissue to find hidden HIV that standard blood tests miss. The goal was to understand why the virus persists in th…

This study looked at 167 men who have sex with men and are on HIV treatment with undetectable virus in their blood. Researchers checked if the virus could still be found in their semen. The goal was to understand any remaining risk of passing HIV to a partner, even when blood tes…

This study looked at how well the kidneys work in people with HIV, including those taking different medications. Researchers tested 30 adults with HIV and compared them to people without HIV. They used a special water test to find early, hidden kidney problems that standard tests…

This study looked at whether a lab-made antibody called VRC01 could help people with HIV control the virus without taking daily HIV medication. Thirteen people who got HIV during a vaccine study and had taken HIV drugs for at least a year stopped their medication under close moni…

This study followed 163 children who started HIV treatment within 12 weeks of birth to track their health, growth, and immune system over about seven years. Researchers measured weight, height, CD4 counts, and virus levels to build a detailed picture of long-term outcomes. No new…

This study looked at 629 adults with different types of pulmonary arterial hypertension (PAH), including those linked to HIV, heart defects, and connective tissue diseases. Researchers tested blood for antibodies that attack blood vessel and lung cells to see if these immune mark…