Cash for quitting: new study tests rewards and meds to help HIV patients stop smoking

NCT ID NCT04490057

Completed Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches could reduce the number of cigarettes smoked per day. The study enrolled 323 adults with HIV who smoked at least 5 cigarettes daily.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine patch, nicotine gum, nicotine nasal spray, nicotine inhaler, varenicline, bupropion
What this could lead to: If successful, this could point toward effective, personalized ways to help people with HIV quit smoking, reducing their risk of smoking-related diseases.
What could go wrong: This is a completed Phase 4 study, but results may not apply to all smokers with HIV. Self-reported smoking reduction may be less reliable than objective measures.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease nicotine dependence Tobacco Use Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOBACCO USE CESSATION

Contacts and locations

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Locations

Bridgeport Hospital Infectious Disease Clinic

Bridgeport, Connecticut, 06110, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
SUNY Downstate STAR Clinic

Brooklyn, New York, 11203, United States
Yale University School of Medicine

New Haven, Connecticut, 06510, United States

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