Could giving TB pills on day one save more lives?

NCT ID NCT06739915

Completed Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The trial involved 364 adults in South Africa and compared this new method to standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TB prevention medicine (TPT)
What this could lead to: If successful, this approach could help more people with HIV get TB prevention quickly, reducing TB cases in high-risk populations.
What could go wrong: This is a small pilot study (364 participants) in one country, so results may not apply elsewhere. Giving prevention medicine before ruling out active TB carries a small risk of delaying proper TB treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease tuberculosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV/AIDS TUBERCULOSIS

Contacts and locations

Locations

Perinatal HIV Research Unit

Soweto, Gauteng, 1864, South Africa

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