HIV/AIDS

This study is testing a mobile health system that sends text reminders and offers support to help women with HIV stick to their treatment plan. The goal is to reduce stigma and medical mistrust while improving clinic attendance and medication use. About 80 women who have had trou…

This study tests a program called ADELANTE for Latino adults with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the program helps …

This study tests whether combining medication (varenicline or nicotine patch) with extra support can help people with HIV quit smoking. Smoking is especially harmful for those with HIV, shortening life more than the virus itself. The trial will enroll 340 adults with HIV who smok…

This study tests a program called Mlambe for married couples in Malawi where one partner drinks heavily and both are affected by HIV. The program offers savings accounts, money management lessons, and relationship skills training to help couples reduce alcohol use and improve com…

This study tests a 4-month online program called Women SHINE for 360 women living with HIV who have experienced violence and struggle to take their HIV medication regularly. The program includes one-on-one coaching, support groups, and online resources to help improve medication …

This study tests whether daily text reminders and small financial rewards can help people with HIV take their medication consistently. Researchers will enroll 550 adults in Uganda who recently started HIV treatment. Participants will use a special pill bottle that records each op…

This study tests a system that uses a special pill bottle to track when HIV medication is taken. If doses are missed, the system alerts a care team who can help with things like food, housing, or transportation. The goal is to see if this approach helps 110 adults with HIV take t…

This study tests whether a program led by peers (trained community members) can help women at high risk for HIV use prevention methods like PrEP more consistently. About 60 HIV-negative women in Uganda will receive the program and be followed for 6 months. The goal is to see if t…

This study combines peer navigation (trained community members who offer guidance) with a mobile health app to help gay, bisexual, and transgender people in rural Appalachia access HIV, STI, and HCV testing and prevention services. About 141 participants will be split into two gr…

This study works with over 1,200 young people aged 14-24 in Nigeria to make HIV self-testing and prevention services more available and long-lasting. Researchers will compare standard program delivery with enhanced strategies to see which helps community organizations keep offeri…

This study tests whether a brief alcohol counseling program helps heavy drinkers at high risk for HIV stay on their prevention medications (PrEP or PEP). Researchers will enroll 400 adults in Kenya and Uganda who visit bars or drinking venues. The goal is to see if the counseling…

This study is testing whether a mobile app called MyPEEPS can help young men who have sex with men (ages 16-29) avoid getting HIV. The app provides tailored information and support to encourage safer sex and use of PrEP (a daily pill that prevents HIV). Researchers will compare H…

This study tests a program called PrEP My Way, designed to help young women aged 16-24 in Kisumu, Kenya, continue using HIV prevention medicine. Participants can choose between a daily pill, a long-acting injection, or a vaginal ring, along with support from peers. The goal is to…

This study tests whether a mobile app plus virtual peer support can help young men (ages 16-25) who are at high risk for HIV start and stick with PrEP, a daily pill that prevents HIV. The study enrolls 500 HIV-negative participants across the U.S. who own a smartphone and have ha…

This study looks at 200 people with HIV to see if two types of HIV drugs (NNRTI and INSTI) cause different amounts of fat buildup or scarring in the liver. Participants will have ultrasound and other scans to measure liver health. The goal is to understand which drug might be saf…

This study looks at the bacteria living in the lungs of 150 adults with active tuberculosis (TB), including those also living with HIV. Researchers will collect samples from infected and healthy parts of the lung before, during, and after TB treatment to see how the bacteria chan…

This study pauses HIV medication in 40 volunteers to closely watch how the virus and body interact early on. Participants stop their antiretroviral therapy for up to three weeks and have frequent check-ups. Most will restart treatment within three weeks, even if the virus stays u…