HIV/AIDS

This study tests whether using simple, fast urine tests and viral load checks at the clinic can help people with HIV stick to their medication and keep the virus under control. About 539 people starting HIV treatment in South Africa will take part. The goal is to see if this appr…

This study tests a video-based program called VITAL Start for Adolescents to help teens living with HIV take their medication regularly and stay healthy. About 1,800 teens and their caregivers in Malawi will either watch the videos plus get standard care, or just get standard car…

This study tests if semaglutide, a drug used for diabetes and weight loss, can reduce dangerous belly fat and improve heart health in people with HIV who have extra fat around the waist. About 108 adults with HIV and a high BMI will receive either the drug or a placebo for 32 wee…

This study tests a smartphone-based system to help community health workers support people with both TB and HIV in South Africa. The goal is to improve treatment success, reduce deaths, and keep patients engaged in care. The approach uses video directly observed therapy and other…

This study tests a program that combines weekly video chats with a counselor and a mobile app to help young adults (ages 18-29) living with HIV get their virus levels under control. Participants who are not yet virally suppressed will be randomly assigned to either the program or…

This study tests whether a mix of a DNA vaccine, a booster vaccine, an immune stimulant, and special antibodies can help people with HIV control the virus after stopping their daily antiretroviral therapy. About 11 participants will receive the combination and then pause their re…

This study tests ways to help 880 adolescents and young adults with HIV in Kenya stay engaged in their care. Participants first get either standard care or electronic navigation. If they miss a visit, they are reassigned to standard care, peer support, or cash incentives. The goa…

This study tests a program to help men who have sex with men in Lima, Peru get HIV testing and connect to treatment or prevention services. The program offers HIV tests at social venues and uses a text-messaging app to share information and support. The goal is to see if this app…

This study compares a shorter course of steroids (8 days for moderate cases, 14 days for severe) against the standard 21-day treatment for Pneumocystis pneumonia (PCP) in people with HIV/AIDS. The goal is to see if the shorter regimen works just as well at preventing death and ma…

This study tests a new online program called ORCHID, designed to help aging women with HIV feel better emotionally and stay in care. The program teaches skills to build positive feelings and cope with stress. Researchers will enroll 30 women from a Miami HIV clinic to see if the …

This study compares two methods of rolling out a program called Bridges, which teaches financial skills and provides support to young people ages 11-17 who lost parents to AIDS. About 1,440 students from 48 schools in Uganda will take part. The goal is to see which method works b…

This study looked at whether combining patient questionnaires, staff training, and telemedicine could help people with HIV get better care for mental health and substance use issues. It was designed for adults receiving HIV care at five clinics in Alabama. The study was withdrawn…