Could a vaccine given during pregnancy shield infants from a deadly virus?

NCT ID NCT06325657

Completed ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participants and follows both mothers and their babies for up to 6 months after birth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RSVpreF vaccine
What this could lead to: If successful, this vaccine could help protect infants born to mothers with HIV from severe RSV infections, potentially reducing hospitalizations and deaths.
What could go wrong: This is a phase 3 trial, but results may not confirm full protection or safety for all. The vaccine may cause side effects or not generate enough immunity in this specific population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease respiratory tract infectious disorder respiratory syncytial virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY SYNCYTIAL VIRUS

Contacts and locations

Locations

Botho Ke Bontle Health Services

Pretoria, Gauteng, 0184, South Africa
FAMCRU - Worcester

Worcester, Western Cape, 6850, South Africa
Gole Biomed Research Centre

Polokwane, Limpopo, 0699, South Africa
Gugulethu Green Clinic

Cape Town, Western Cape, 7750, South Africa
Josha Research

Bloemfontein, Free State, 9301, South Africa
MRC Unit on Child And Adolescent Health

Cape Town, Western Cape, 7700, South Africa
Qhakaza Mbokodo Research Clinic

Ladysmith, KwaZulu-Natal, 3370, South Africa
REIMED Reiger Park

Boksburg, Gauteng, 1459, South Africa
Setshaba Research Centre

Pretoria, Gauteng, 0152, South Africa
Synergy Biomed Research Institute

East London, Eastern Cape, 5241, South Africa
University of Witwatersrand (WITS) - Vaccines and Infectious Diseases Analytics (VIDA)

Johannesburg, Gauteng, 2013, South Africa
Wits RHI

Johannesburg, Gauteng, 2001, South Africa
Wits VIDA Nkanyezi Research Unit

Johannesburg, Gauteng, 2093, South Africa
Worthwhile Clinical Trials

Benoni, Gauteng, 1500, South Africa

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