HIV-Positive hearts for HIV-Positive patients: a lifesaving experiment?

NCT ID NCT06659952

Recruiting now Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether hearts from HIV-positive deceased donors are as safe and effective for HIV-positive recipients as hearts from HIV-negative donors. Fifty HIV-positive patients with advanced heart failure will receive a heart transplant, with the donor's HIV status determined by organ availability. Researchers will track survival, graft function, and serious side effects for three years after transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HIV-positive heart transplant
What this could lead to: If successful, this could expand the donor pool for HIV-positive patients needing heart transplants, potentially reducing wait times and saving lives.
What could go wrong: This is a small, early-stage study with only 50 participants, so results may not apply broadly. There are also unknown risks of using HIV-positive donor hearts in HIV-positive recipients.

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Conditions

The condition(s) this trial relates to.

advanced heart failure HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED END STAGE HEART FAILURE HIV INFECTION

Contacts and locations

Locations

UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

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