University Of Texas Southwestern Medical Center

This study is investigating whether taking vitamin D supplements can help people with sarcoidosis, an inflammatory disease. Researchers will give vitamin D to some participants with low levels and a placebo to others to see if it reduces inflammation and improves lung function an…

This study is testing a new support program to help blood donors who have inherited high cholesterol (familial hypercholesterolemia) get better treatment. Researchers will compare two groups: one receiving standard information and another getting extra support and education. The …

This study is testing if giving a higher dose of the drug cabozantinib can help control advanced kidney cancer in patients whose cancer has started growing again while on the standard dose. The trial will enroll 18 adults with advanced kidney cancer who previously benefited from …

This study aims to find out if a highly focused, non-surgical radiation treatment is better than a limited surgery for people with early-stage lung cancer who are at high risk for complications from major surgery. It will compare survival rates over three years between patients r…

This study is testing whether a smartphone app can help people with kidney problems better manage fluid buildup and swelling. Participants will use the app daily to track their weight and blood pressure, and it will provide personalized instructions for adjusting their water pill…

This study is comparing two treatments for a condition where a small adrenal gland tumor causes mildly high cortisol levels. Researchers want to see if surgically removing the gland or using a weight-management medication (semaglutide) works better to improve the body's response …

This study is testing a three-part treatment for people whose advanced kidney cancer has started to spread again in a few spots. It combines a drug injected into a tumor to activate the immune system, very precise radiation to those spreading spots, and continued immunotherapy. T…

This study is testing a new approach for early-stage, hormone-positive breast cancer. It gives patients a single, high-dose radiation treatment before surgery to try to shrink or eliminate the tumor. The trial also explores using a special ultrasound instead of surgery to check l…

This study is testing a drug called belantamab mafodotin for people with AL amyloidosis that has come back or hasn't responded to other treatments. The goal is to find a safe and effective dose and see if it can reduce the disease in the blood and improve organ function, especial…

This study aims to see if a specific brain activity pattern, called Biotype-1, can predict which people with schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis will respond exceptionally well to the medication clozapine. About 320 participants will be ran…

This study is testing if combining three standard heart medications into a single 'polypill' can help people recover better after a heart attack. The goal is to see if taking one pill instead of three improves how well patients stick to their medication, which could lower the ris…

This study aims to find out if cooling therapy (therapeutic hypothermia) is better than keeping a normal body temperature for newborns with mild brain injury caused by oxygen deprivation during birth. Researchers will follow 460 infants for two years to see how their development …

This study is testing if a home-based exercise program, delivered through videos and virtual coaching, can help adults with a common type of heart failure (HFpEF) or those at risk for it. The goal is to see if this convenient, remote approach can improve exercise capacity, physic…

This study is testing whether combining two existing drugs, pembrolizumab and lenvatinib, can help control advanced cervical cancer that has returned or spread. It is for women whose cancer has continued to grow despite previous treatments, including other immunotherapies. The ma…

This study is testing if the drug tafamidis is safe and helpful for people who have already received a heart transplant because of a serious disease called ATTR cardiac amyloidosis. The disease causes harmful proteins to build up and damage organs. Even after a heart transplant, …

This early-stage study is testing a new way to deliver radiation for hard-to-treat lung tumors located near the heart or major airways. It aims to see if giving fewer, more powerful radiation doses spaced weeks apart, guided by real-time MRI scans, can be safer for patients while…

This study is comparing two different ways to provide follow-up care to new mothers after they leave the hospital. It aims to see if using telemedicine (video calls) or automated text/email alerts can help catch health problems like high blood pressure or infections sooner. The g…

This study is testing a new, personalized plan for radiation therapy in men whose prostate cancer shows signs of returning after surgery. Instead of giving everyone the same intensive treatment, doctors will first give a shorter course of radiation to the prostate area. Based on …

This study is testing whether a combination of two immunotherapy drugs, ligufalimab and cadonilimab, can help control advanced liver or bile duct cancers that have worsened after prior immunotherapy. It will enroll about 64 adults whose cancer has spread and is no longer respondi…

This study is testing a shorter, more focused radiation schedule for early-stage larynx (voice box) cancer. It will compare this new approach to standard radiation to see if it causes fewer short-term side effects. The goal is to control the cancer while potentially making treatm…

This study is testing if the antidepressant escitalopram can help reduce the number of severe asthma attacks in adults. It will involve about 105 adults with moderate-to-severe asthma who still have frequent flare-ups despite their regular inhaler treatments. Participants will be…

This study aims to find the safest mix of two common anesthesia drugs, propofol and etomidate, for patients with heart or lung conditions undergoing common endoscopy procedures. Researchers will compare two different drug ratios to see which one better maintains stable blood pres…

This study is testing whether combining a targeted cancer drug (enfortumab vedotin) with precise radiation therapy can help shrink tumors before bladder removal surgery. It's for patients with muscle-invasive bladder cancer who cannot receive standard cisplatin chemotherapy. The …

This study is testing if freezing a tumor (cryoablation) followed by an immunotherapy drug (pembrolizumab) before surgery can help prevent cancer from coming back in women with a hard-to-treat type called triple-negative breast cancer. It's for women who still have cancer after i…

This study is testing whether blocking the nerves around the prostate can slow or stop the spread of prostate cancer in men with high-risk disease. Researchers will compare one versus two injections of a nerve-blocking agent (ethanol) to see which is more effective at reducing ne…

This study is testing a new combination of an immunotherapy drug (atezolizumab) with three chemotherapy drugs for children and young adults whose solid tumors have returned or not responded to prior treatment. The main goals are to first check if the combination is safe and then …

This study is testing whether having a doctor visit patients at home helps manage high blood pressure and type 2 diabetes better than standard clinic visits. Researchers will compare health outcomes for 100 adults who receive two home visits versus those who get usual clinic care…

This study is testing if ketamine, given through an IV, can help people with moderate to severe methamphetamine addiction reduce or stop their drug use. It will compare ketamine to another sedative drug (midazolam) in 120 adults over 12 weeks. Participants will receive eight IV i…

This early-stage trial is testing personalized radiation therapy approaches for small cell lung cancer and brain tumors. The study aims to make radiation treatment safer and more effective by adjusting it based on how each patient's tumors respond during therapy. Researchers will…

This study aims to find out if heart transplants from HIV-positive donors are as safe and work as well for HIV-positive recipients as transplants from HIV-negative donors. The research will follow 50 adults with both HIV and advanced heart failure who receive heart transplants, c…

This study is testing a new type of MRI scan to see if it can better identify which patients with severe heart disease will benefit most from bypass surgery. Researchers will compare scans from 30 patients before and after surgery to scans from healthy people. The goal is to impr…

This study is testing if a combined PET/MRI scan can better tell the difference between aggressive kidney tumors that need treatment and harmless or slow-growing ones that may not. Participants are adults with a suspicious kidney mass who are already scheduled for a standard MRI.…

This study aims to develop better tools for diagnosing Parkinson's disease and similar movement disorders. Researchers will use advanced brain scans and artificial intelligence to identify patterns that can distinguish between different conditions and predict how quickly they mig…

This large national trial aims to find the best method for early liver cancer detection in people at high risk. It will compare the current standard approach (an ultrasound plus a blood test) against a newer blood test alone. The goal is to see which method is more effective at f…

This large study is testing whether helping older adults (70+) lower their blood pressure more than usual can prevent or slow down memory loss and dementia. It will compare a special support program for blood pressure control against regular medical care in 4,000 people. Research…

This study is testing if adding a trained health coach to a community re-entry program can help people who have been involved with the justice system get better access to HIV prevention medication (PrEP). The health coach will talk with participants about health, offer HIV testin…

This study is testing a new program to prevent HIV infections among people in the Dallas County Jail. A navigator will meet with interested individuals to discuss their HIV risk, offer testing, and provide education about PrEP, a daily pill that prevents HIV. The goal is to succe…

This study is testing whether a compound from green tea (EGCG) can help prevent liver cancer in people with cirrhosis, a serious liver scarring condition. Sixty participants with a high risk of developing cancer will take either the green tea extract or a placebo pill for 24 week…

This study is testing a new system to prevent heart failure in people with type 2 diabetes. It uses a simple blood test and a risk score to identify patients at high risk. When a high risk is found, the system alerts the patient's doctor to start proven preventive medications ear…

This study is testing whether a daily supplement called D-mannose can prevent recurring urinary tract infections (UTIs) in women after menopause. Researchers will compare D-mannose to a placebo (inactive pill) in 90 women with a history of frequent UTIs over a 12-month period. Th…

This study aims to find practical ways to protect older adults from heart strain during dangerous heat waves. Researchers will test simple cooling methods like fans, water spray, or both on 100 healthy seniors aged 65+. Participants will experience simulated heat wave conditions …

This study is testing whether a simple home treatment—using a heated blanket on the legs—can help prevent dangerous high blood pressure disorders in pregnant women with obesity. Researchers will enroll 118 women early in pregnancy and randomly assign them to use either a warm bla…

This study is testing if a low dose of an anti-inflammatory drug called colchicine can help people with a specific type of chronic heart failure (HFpEF) who also have body-wide inflammation. For 3 months, 60 participants will take either the drug or a placebo pill to see if it im…

This study is testing if a gentle electrical stimulation of a nerve near the ankle can help reduce urinary leakage in children with spina bifida. Kids aged 8-18 will learn to use the device at a clinic and then do the 30-minute treatments at home for 6 weeks. The goal is to see i…

This study is testing if a small, non-invasive device placed on the ear can help reduce pain after back surgery. The device gently stimulates nerves to potentially lower pain signals to the brain. Researchers will compare it to a fake device in 20 patients to see if it helps peop…

This study is testing whether freezing specific nerves in the throat can reduce symptoms of a persistent, nerve-related cough. It involves a small group of adults who have had a cough for over 8 weeks that hasn't responded to other treatments. Doctors will apply a freezing treatm…

This study aims to find which of three breathing therapies works best to help patients' lungs recover after heart surgery. Researchers will compare three different devices that help expand the lungs to prevent complications like lung collapse. The goal is to see which method impr…

This study is testing if an online support program can help teenagers (ages 15-18) who have just left a psychiatric hospital. The program connects teens with trained peer mentors and specialists for virtual meetings and group support over 8 weeks. Researchers want to see if this …

This study aims to see if wetting the skin helps people with healed burns control their body temperature better when exercising in hot conditions. Researchers will compare 40 participants—some without burns and some with different levels of past burns—while they exercise with eit…

This study is looking at whether a treatment that reduces hand tremors in people with Essential Tremor also helps with the social anxiety and stigma caused by the shaking. Researchers will measure changes in psychological distress and social avoidance one year after patients rece…

This study is testing if simple cooling methods, like wearing a wet T-shirt or having wet skin, can help people with heart failure stay cooler and reduce stress on their hearts during hot weather. Researchers will compare these methods to no cooling in a simulated heat wave. The …

This small pilot study is testing whether a gentle, non-invasive brain stimulation technique can help improve social behaviors and thinking patterns in women with anorexia nervosa. Researchers will use a device called tDCS to stimulate a part of the brain called the cerebellum wh…

This study is testing a new way to combine three different types of heart scans to better understand the health of heart muscle in people with severe heart disease. It will enroll 15 people, including 9 patients scheduled for bypass surgery and 6 healthy volunteers. The goal is t…

This study is testing how well a new type of imaging scanner works for detecting prostate cancer. It involves men who are already scheduled to get a standard PET scan for their cancer. Participants will have an extra scan on the new machine right after their regular scan, but the…

This study aims to understand how natural fluctuations in the female hormone estradiol affect the spinal cord's ability to adapt and respond to signals. Researchers will recruit 50 healthy young women and men to measure spinal cord excitability using safe, low-level electrical ne…

This study aims to understand how kidney and bladder cancers use different nutrients from the blood to grow and survive. Researchers will study tissue samples from 600 patients who are already scheduled for surgery or biopsy for their cancer. By tracking specially labeled nutrien…

This study aims to better understand how Parkinson's disease affects the brain's ability to control and regulate movements and actions. Researchers will compare 50 people with Parkinson's disease to healthy volunteers using simple computer tasks with a joystick. The study will ex…

This study aims to understand if a common nerve block procedure affects the smallest blood vessels in the eye. Researchers will scan the eyes of 50 adults with severe brain injuries before and after they receive the nerve block as part of their standard care. The goal is to gathe…

This study aims to collect data on pupil size and reactions in 1,000 patients in intensive care units. Researchers are using a special device called a pupillometer to take these measurements. The goal is to establish what 'normal' pupil readings look like in very sick patients, w…

This study aims to understand if eating less phosphate—a mineral found in many foods—can improve how well your muscles work during exercise and reduce harmful belly fat. Researchers will compare two diets in 124 healthy adults: one with typical phosphate levels and one with lower…

This pilot study aims to see if a gentle, non-invasive electrical stimulation applied to the ear is safe and feasible for ICU patients with moderate to severe traumatic brain injury. Researchers will enroll 42 patients to test the device and measure its effect on blood markers of…

This study aims to understand what causes the skin problems in lupus by creating a national registry of 1000 patients. Researchers will collect health information, blood, and skin samples to identify genes and proteins linked to the disease. The goal is to improve future diagnosi…

This study is testing a program that offers financial help for travel and other costs to people in cancer treatment trials. Researchers want to see if this program helps more people from different backgrounds join and stay in these important studies. They will survey and intervie…

This study is testing a new type of MRI scan to see how brain tumors process energy differently than healthy brain tissue. It is for adults newly diagnosed with a brain tumor who have not yet started treatment. The goal is to gather information that could help develop future trea…

This study aims to learn how to better control prosthetic hands by temporarily implanting tiny electrodes into the nerves of the arm. Researchers will work with 25 people who have had a hand or arm amputation to record nerve signals when they try to move their 'phantom' hand and …

This study aims to understand if two common heart medications (propranolol and metoprolol) cause older adults to overheat more quickly during extreme heat. Researchers will expose 22 healthy adults aged 65+ to 3 hours of simulated heat while monitoring their body temperature. The…

This study aims to understand how a simulated burn injury affects the body's ability to cool down after exercising in the heat. Researchers will compare how quickly body temperature and heart rate return to normal in the same healthy adults with and without a special material tha…

This study aims to understand how depression affects different types of thinking, especially those related to emotions, in adults. Researchers will compare brain scans and thinking tests from 120 people with depression to 120 healthy volunteers. The goal is to map how depression …

This study aims to test a new brain imaging method to see how healthy brains create energy and important brain chemicals. Researchers will use a special type of MRI scan on 28 healthy volunteers to measure these processes. The goal is to gather information to help understand brai…

This study aims to understand if standard medications for a heart condition called ATTR amyloidosis reduce harmful protein levels in the blood over time. Researchers will follow 50 patients already taking or starting these medications. They will check blood samples regularly to s…

This study aims to understand how older adults process two drugs (sirolimus and everolimus) that might slow down aging. Researchers will measure drug levels in the blood and check for changes in biological signs of aging over three months in 60 participants aged 65 and older. The…

This small, early study aims to understand how a single dose of ketamine affects brain pressure and oxygen levels in patients with severe traumatic brain injury. Researchers will monitor 10 critically ill patients who already have special brain monitors in place. The goal is to g…

This study aims to better understand multiple sclerosis by tracking disease patterns and treatments in a large group of people over many years. It's a registry study, meaning participants report their health information regularly but don't receive any treatment. The information h…

This study aims to understand how a drug called scopolamine affects brain activity during memory tasks. Researchers will work with 60 adults who have epilepsy and already have electrodes implanted in their brains for medical monitoring. Participants will complete memory games on …

This study aims to understand how phosphate from food affects people with chronic kidney disease (CKD). Researchers will feed 60 participants (30 with CKD, 30 without) three different phosphate diets over 21 days and measure changes in their blood and urine. The goal is to find b…

This study is testing a new, non-invasive eye scan to see if it can help doctors understand brain conditions like stroke and brain bleeds. Researchers will compare scans from 50 people with these neurological illnesses to scans from healthy people. The goal is to gather early inf…