University Of Texas Southwestern Medical Center

This study tests a personalized approach to radiation therapy for men whose prostate cancer has returned after surgery. Instead of giving everyone the same treatment, doctors will adjust the plan based on how well the cancer responds to initial radiation. Those who respond well m…

This early-stage study tests a personalized radiation technique called PULSAR for lung cancers located near the center of the chest. The goal is to make treatment safer while still effectively controlling the tumor. About 30 adults with primary or metastatic lung cancer will rece…

This study tests whether adding two immunotherapy drugs (CDX-1140 and CDX-301) to standard chemotherapy (PLD) is safe and helps control metastatic HER2-negative breast cancer. About 30 people with advanced cancer that has not responded to other treatments will take part. The goal…

This study tests whether curcumin, a natural compound found in turmeric, can slow or stop the progression of low-risk prostate cancer in men who are not receiving immediate treatment. About 291 men with early-stage prostate cancer will take either curcumin or a placebo daily for …

This study tests a mobile app called DynamiCare, combined with a patient navigator, to help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine. The app uses at-home saliva tests and financial rewards to encourage healthy be…

This study tests whether text messages can help parents lock up guns and medications after their teen's suicide-related emergency room visit. About 129 teens aged 12-17 and their parents will be followed for 12 weeks. The goal is to see if simple reminders can reduce access to da…

This study tests whether hydroxycitrate, a molecule similar to citrate, can reduce the recurrence of calcium phosphate kidney stones. Researchers will give 25 stone formers either hydroxycitrate, potassium citrate, or a placebo, and measure how well their urine prevents stone for…

This study is for children whose solid tumors have returned or not responded to standard therapy. It combines an immunotherapy drug (atezolizumab) with three chemotherapy drugs to see if the mix is safe and can shrink tumors. About 23 children will take part, and the main goals a…

This study tests a 12-week home-based cardiac rehabilitation program delivered through a smartphone app for 332 adults with heart failure who cannot attend in-person rehab. Participants are split into two groups: one uses the app program, the other receives standard attention. Th…

This study tests whether orlistat, a drug that blocks fat absorption, can safely lower very high blood triglycerides in people with type 1 hyperlipoproteinemia, a rare genetic disorder. About 28 participants aged 8 and older will take orlistat or a placebo for several months. The…

This study compares clozapine and risperidone in people with schizophrenia, schizoaffective disorder, or bipolar I disorder with psychosis. Researchers want to see if a specific brain biotype (Biotype-1) responds better to clozapine. About 320 participants will be randomly assign…

This study tests a drug called belantamab mafodotin in people with a rare blood disease called AL amyloidosis that has come back or not responded to other treatments. The goal is to find the safest and most effective dose. The study has two parts: first, different doses are teste…

This study tests whether giving a single dose of a targeted radiation drug (Iomab-B) before standard CAR-T cell therapy can improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 30 participants will receive the radiation followed by CAR-T ce…

This study looks at bone health in people with cystic fibrosis (CF) and tests a drug called denosumab to treat bone disease. Up to 100 participants, including both CF patients and healthy volunteers, will have bone scans and blood tests. A smaller group of 10 CF patients with bon…

This study tests whether cooling therapy (lowering body temperature for 72 hours) helps babies born with mild brain injury from oxygen loss, compared to standard care without cooling. Researchers will track 460 newborns' development at age 2 and monitor side effects. The goal is …

This study is testing whether two drugs, pembrolizumab (Keytruda) and lenvatinib (Lenvima), can slow tumor growth in people with cervical cancer that has spread or come back. About 30 participants will receive the combination. The main goal is to see how many people's tumors shri…

This study looks at two ways to manage recurrent urinary tract infections (UTIs) in women. One group takes a daily antibiotic called nitrofurantoin. The other group has a minor procedure to burn away tiny spots in the bladder (electrofulguration) and also takes the daily antibiot…

This early-phase trial is testing a new way of giving radiation therapy (ultra-fractionated, short course) along with standard chemotherapy for people with locally advanced rectal cancer. The goal is to see if this combination can shrink the tumor enough to avoid surgery. The stu…

This early-stage trial tests a gene therapy called scAAV9/JeT-GAN for giant axonal neuropathy (GAN), a rare, fatal nerve disease in children. The therapy is injected directly into the left vagus nerve to target autonomic nervous system symptoms. Only 4 people who have already rec…

This study is testing ablative therapies—treatments that destroy cancer cells with heat or cold—for men with localized prostate cancer. Researchers want to see how well these treatments control cancer and affect quality of life, including urinary and sexual function. The study wi…

This study is for people with head and neck cancer. It compares two types of radiation therapy: one that treats only the cancer and nearby lymph nodes (INRT) and one that treats a larger area (ENI). The goal is to see if the smaller treatment area works just as well and causes fe…

This study tests a personalized approach to radiation therapy for high-risk prostate cancer. Using special PET scans that highlight cancer cells, doctors will adjust the timing and dose of radiation to each patient's tumor. The goal is to improve treatment effectiveness while red…

This study compares two treatments for early-stage lung cancer in patients who are high-risk for surgery: removing part of the lung (sublobar resection) versus precise, high-dose radiation (stereotactic ablative radiotherapy). About 272 participants will be randomly assigned to o…

This study tests INTACS prescription inserts, small plastic implants placed in the cornea, to reduce astigmatism and improve vision in people with keratoconus. The goal is to help patients who can no longer see well with glasses or contacts and may otherwise need a corneal transp…

This study tests whether intravenous ketamine can help people with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 adults will receive either ketamine or a mild sedative (midazolam) in six sessions. The main goal is to see if more partici…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This study looks at whether a community program that teaches families about healthy eating, physical activity, and sleep can help children who are overweight or obese. About 160 children will be randomly assigned to either join the program right away or be placed on a waitlist. T…

This study looks at two treatments for mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers want to see if removing the adrenal gland (surgery) or taking semaglutide (a weight-loss drug) better improves insulin resistance and …

This study tests a program to help blood donors who have familial hypercholesterolemia (a genetic condition causing very high cholesterol) get proper treatment. One hundred participants will either receive standard notification about their condition or a bundle of extra support, …

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This study is testing whether temporary electrodes placed on nerves in the arm can help people with hand amputations control a prosthetic hand more naturally and feel sensations like touch and movement. Twenty-five adults with hand, forearm, or arm amputations will have the elect…

This phase 2 trial is testing whether a combination of two immune-boosting drugs, ligufalimab and cadonilimab, can shrink advanced liver or bile duct cancers that have stopped responding to prior treatments. About 64 adults will receive the drugs by IV every three weeks. The main…

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…

This phase 2 trial tests whether escitalopram, an FDA-approved antidepressant, can reduce severe asthma flare-ups in people with moderate to severe asthma who have had at least three attacks in the past year. About 105 participants will receive either escitalopram or a placebo pi…

This study looks at whether hearts from HIV-positive deceased donors are as safe and effective for HIV-positive recipients as hearts from HIV-negative donors. Fifty HIV-positive patients with advanced heart failure will receive a heart transplant, with the donor's HIV status dete…

This study tests whether combining three standard heart medications (aspirin, a blood thinner, and a statin) into a single daily pill helps people who've had a heart attack take their medicine more consistently. About 1,000 adults who recently had a heart attack and a stent place…

This study looks at whether vitamin D supplements can help people with sarcoidosis who have low vitamin D levels. Researchers will give some participants vitamin D2 and others a placebo, then measure changes in lung function and quality of life. The goal is to see if correcting v…

This phase II trial compares a new, shorter radiation schedule (LT-SABR, given over 1-2 weeks) to standard radiation (over 5-6 weeks) for early-stage laryngeal cancer. The goal is to see if the shorter schedule causes fewer severe side effects in the first 3 months. About 67 adul…

This study tests whether adding an immune-boosting drug (IMSA101) and targeted radiation to standard immunotherapy can help control metastatic kidney cancer that has started to grow again. About 15 adults with clear cell kidney cancer that has progressed in up to 5 spots will rec…

This study tests personalized radiotherapy approaches for people with lung cancer, brain metastases, or other solid tumors. It aims to see if adapting radiation based on how a patient responds is safe and effective. About 45 adults will participate, receiving either extra radiati…

This study tests a new way to treat early-stage ER+ breast cancer using a single, strong dose of radiation before surgery. It also explores using a special ultrasound with microbubbles to check lymph nodes without a surgical biopsy. The goal is to see if this approach can elimina…

This study compares three breathing therapy devices (EzPAP, Metaneb, and IPPB) to see which one best helps lung recovery after heart surgery. 324 adults who had open-heart surgery will use one of the devices for 10 minutes, four times a day. The goal is to find which therapy impr…

This phase 2 trial is testing whether a higher dose (80 mg) of the drug cabozantinib can help people with advanced kidney cancer whose disease has worsened while on the standard dose. About 18 participants will receive the higher dose daily. The main goal is to see how long the c…

This study tests a mobile app that helps people with kidney problems adjust their water pill (diuretic) doses day by day to control swelling. Thirty participants will use the app for 90 days, entering daily weight and blood pressure readings. The goal is to see if the app helps t…

This study tests a combination of the drug enfortumab vedotin and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for patients who cannot receive standard cisplatin chemotherapy. The trial will test three different schedules of the drug and radiat…

This early-stage study tests whether injecting alcohol around the prostate can block nerve signals that may help cancer grow and spread. Twenty-one men with high-risk prostate cancer who plan to have their prostate removed will receive one or two injections before surgery. Resear…

This study is testing whether regular urine tests every 6 months can find bladder cancer earlier in people at high risk, such as smokers over 50 and those with long-term workplace chemical exposure. Researchers will enroll 1,000 participants and track how many cancers are detecte…

This study tests a dye called pegsitacianine that makes cancer cells glow during surgery. It is for 120 adults with head and neck cancer, including those with an unknown primary tumor. The goal is to see if the dye helps surgeons find and remove all cancer tissue safely.

This study is testing a new type of MRI, called hyperpolarized 13C MRI, to see if it can better identify which patients with heart disease will benefit from bypass surgery. The technique measures how the heart produces energy by tracking two simple molecules. Researchers will com…

This study is testing whether a combined PET and MRI scan (PET/MR) can better tell apart aggressive kidney cancers from slow-growing or harmless tumors. About 97 adults with a suspicious kidney mass will receive the scan during their regular MRI appointment. Researchers hope this…

This phase IV trial will enroll 5,500 people with liver cirrhosis or chronic hepatitis B—conditions that raise liver cancer risk. Participants are randomly assigned to either standard ultrasound screening or a new blood test called GALAD, which measures three proteins. The goal i…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests whether regularly warming the legs with a portable sauna blanket can improve blood vessel health and lower the risk of high blood pressure disorders in pregnant women with obesity. About 118 women will use the blanket at home for 16 weeks, starting early in pregn…

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

This study tests a new way to screen for heart failure risk in people with type 2 diabetes. Doctors use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then offer early prevention treatments. About 300 patients are taking part. The goal is to see if this…

This study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…

This study tests whether a health coach can help people leaving jail learn about and get PrEP, a daily pill that prevents HIV. The coach will be part of a re-entry program in Dallas. Researchers will see if this approach is feasible and acceptable to clients and staff.

This study tests whether helping doctors manage high blood pressure more aggressively can prevent cognitive decline and dementia in adults aged 70 and older. Researchers will use a smartphone app and a clinical decision support tool to guide treatment. 4,000 participants will be …

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to se…

This study tests whether a green tea compound called EGCG can lower the risk of liver cancer in people with cirrhosis. Researchers will give EGCG or a placebo to 60 adults with cirrhosis and no history of liver cancer. The goal is to see if EGCG reduces a biomarker linked to canc…

This pilot study tests whether a peer support program can help young adults (ages 18-27) recently discharged from a psychiatric hospital. Participants get one-on-one and group meetings with trained Peer Support Specialists and recovery organizations, while a comparison group rece…

This study tests whether using a video camera (video laryngoscopy) helps doctors give surfactant—a medicine that helps lungs work—to very premature babies more successfully on the first try compared to the standard direct-look method. About 100 babies born at 28 weeks or earlier …

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can help reduce certain autism symptoms, like repetitive behaviors and hyperactivity, in children and young adults aged 4 to 17. Researchers will apply a mild electrical current to the cerebellu…

This study looks at how to improve laser therapy for port-wine birthmarks in children. The goal is to reduce the number of treatments needed and make the therapy work better, especially for stubborn cases. About 200 children aged 2 months to 18 years will take part. Researchers w…

This study compares a nasal spray form of ketorolac (Sprix) to oral diclofenac pills for managing pain from ureteral stents placed after kidney stone surgery. Researchers will enroll 80 adults to see if the nasal spray provides faster pain relief and reduces unplanned doctor visi…

This study tests two types of social therapy for young adults (ages 18-30) with eating disorders or anxiety. One group gets educational sessions about brain function and social processing; the other adds interactive art tasks done in teams. Researchers will track changes in eatin…

This study tests whether a low dose of colchicine, an anti-inflammatory drug, can improve exercise capacity in people with heart failure and chronic inflammation. Sixty participants will be randomly assigned to receive either colchicine or a placebo for three months. Researchers …

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study tests a treatment called transcutaneous tibial nerve stimulation (TTNS) for children aged 8-18 with spina bifida who still leak urine despite regular catheter use. TTNS uses mild electrical pulses at the ankle to stimulate a nerve that helps control the bladder. Partic…

This pilot study tests whether a gentle electrical current applied to the back of the brain (cerebellum) can improve social behaviors and mental flexibility in 15 women and girls aged 15-30 with anorexia nervosa. Participants receive two types of stimulation (anodal and cathodal)…

This study tests a procedure called laryngeal cryotherapy, which freezes overactive nerves in the throat to reduce chronic cough. Researchers will enroll 28 adults with neurogenic cough (a cough lasting 8+ weeks with no other cause). Participants will receive one cryotherapy trea…

This study tests an online recovery program for teens aged 15-18 who have been discharged from a psychiatric hospital after suicidal thoughts, attempts, depression, or anxiety. The program pairs them with trained peer support specialists and teen peers for one-on-one and group me…

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find a safer way …

This study tests whether a gentle, non-invasive device placed on the ear can help reduce pain after lumbar (lower back) surgery. The device stimulates nerves in the ear to change how the brain processes pain. Researchers will enroll 20 adults having back surgery to see if this ap…

This study tests whether a tailored, home-based exercise program (with or without weight loss medications) can improve exercise capacity and quality of life in 120 adults with heart failure with preserved ejection fraction (HFpEF). Participants will follow exercise videos and mee…

This study tests whether wetting the skin can prevent dangerous rises in body temperature during exercise in hot conditions for burn survivors. Researchers will compare cooling methods in 40 adults, including those with and without burn injuries. The goal is to find a simple way …

This study is looking for early signs of heart amyloidosis in Black adults who carry a specific gene change (V122I TTR) that raises their risk. Researchers will use heart MRI scans and blood tests to detect protein buildup before symptoms appear. The goal is to find ways to diagn…

This early-phase trial will test how Acetadote, a drug that affects cell damage, changes metabolism in people with newly diagnosed glioblastoma. Ten participants will receive Acetadote before surgery, and researchers will use MRI scans and tumor tissue analysis to measure metabol…

This study is testing the drug sirolimus in 60 healthy adults aged 65 and older to see how the body processes it and how it affects aging-related markers. Participants take sirolimus tablets daily for several weeks, with dose adjustments to reach a target blood level. The goal is…

This study aims to understand how the immune system reacts to a common breast cancer treatment combination of letrozole and abemaciclib. Researchers will collect tumor and blood samples from 60 postmenopausal women with hormone receptor-positive breast cancer before and after two…

This study looks at how to best share personal heart health information to encourage healthy changes. About 1,500 people from the Dallas Heart Study will receive their results in one of two letter formats: one with simple color-coded risk categories, the other with exact numbers …

This study looks at how voice sounds change when people strain their vocal cords. Researchers will measure specific voice features in 100 adults, some with and some without vocal cord injury. The goal is to find early warning signs that could help prevent voice damage before it h…

This study looks at how melanoma tumors process energy, specifically glucose, to see if certain metabolic patterns are linked to cancer spread. Researchers will give a special glucose tracer to 400 adults with melanoma before their surgery and analyze the tumor tissue. Participan…

This study is testing a new way to help families decide if their children should be screened for early signs of mental health problems. The children are ages 7 to 21 and have a parent with bipolar disorder. The researchers are creating a video and FAQ to help parents understand t…

This study is testing a device called Intellidrop that automatically drains fluid from the spine during a standard test for normal pressure hydrocephalus (NPH). The device monitors pressure and controls drainage, which may reduce errors and make the process more comfortable for p…

This study looks at how a simulated burn injury affects how quickly the body cools down after exercise in hot conditions. Researchers will compare the same person's recovery with and without a special material on the skin that mimics a burn. The goal is to understand if burn surv…

This study tests whether wetting the skin or wearing a water-soaked T-shirt can help people with heart failure stay cooler and reduce stress on the heart during hot, dry conditions. Researchers will expose 88 participants (half with heart failure, half healthy) to simulated heat …

This study follows 200 people with Multiple System Atrophy (MSA) to see if receiving care from a team of specialists every four months improves their quality of life and eases the burden on their caregivers. Participants and their doctors will complete questionnaires about daily …

This study gives patients with a new brain mass a safe, non-radioactive sugar tracer before surgery to see how their tumor uses energy. Researchers will analyze the tumor tissue and compare it with MRI scans to find patterns that could help identify aggressive tumor cells. The go…

This study is creating a registry of 500 children and adults with morphea (localized scleroderma) to track how the disease behaves over time, what complications arise (like arthritis), and whether it has an autoimmune cause. Participants provide medical history and skin assessmen…

This study looks at whether breathing a low-density helium-oxygen gas mixture can reduce breathlessness and improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF) and obesity. Researchers will measure how much oxygen the body uses during b…

This study tests whether an AI tool called EchoGo can help doctors spot early signs of heart failure in people with type 2 diabetes who have no symptoms. Researchers will send alerts to doctors about patients at risk, and see if this leads to more prescriptions of heart-protectin…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study aims to develop a better way to image lung tumors using MRI and a natural, slightly modified sugar solution. Researchers will look at how tumors burn sugar for fuel by analyzing tumor samples after surgery. The goal is to understand the metabolic pathways of lung cance…

This study looks at CT scans from 2,000 people to see if computer models can better predict how lung cancer will respond to treatment. Researchers will review past patient records and data from a national screening trial. The goal is to improve screening and treatment decisions f…

This study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…

This study is testing a new device that measures pressure inside the skull without needing surgery. The device uses a small pin on the head to detect tiny skull movements with each heartbeat. Researchers want to see if this non-invasive method can give useful information similar …

This study is a large registry that collects health information from up to 10,000 people who received or were evaluated for radiation therapy at UT Southwestern since 2000. Researchers will analyze quality of life and compare outcomes with national data to better understand the b…

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait, along with some healthy volunteers. Researchers will use these samples and medical records to learn how kidney disease starts and gets worse in pe…

This study looks at how the female sex hormone estradiol might change the way the spinal cord adapts. Researchers will use mild electrical stimulation to test nerve responses in 50 healthy young adults. The goal is to understand basic biology, not to treat any disease.

This study tests whether a gentle electrical current applied to the spine (called tsDCS) can improve reflexes, walking, and balance in people who have leg weakness after a stroke. Researchers will measure changes in movement and adaptation over 15 sessions. The goal is to underst…

This study aims to develop a new imaging technique using a special substance called hyperpolarized pyruvate to measure how the brain uses energy and makes neurotransmitters. Researchers will scan 28 healthy adults aged 18 to 60 to create detailed maps of brain metabolism. This is…

This observational study uses a special MRI technique with hyperpolarized carbon-13 pyruvate to see how brain tumors use energy. Researchers will measure metabolic byproducts in 25 adults with brain tumors before any treatment. The goal is to learn more about tumor metabolism, no…

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

This study looks at whether a brain treatment called focused ultrasound can reduce the social stigma that people with essential tremor often face. About 220 adults with essential tremor will have their tremor treated and then be followed for one year. Researchers want to see if l…

This study looks at whether eating too much phosphate—common in many US diets—can reduce your ability to exercise and increase belly fat. Researchers will measure oxygen use during cycling and energy production in muscles. About 124 healthy adults will take part to see if finding…

This study is testing how different levels of dietary phosphorus affect people with moderate chronic kidney disease (stages 3-4) compared to healthy volunteers. Participants will follow three different phosphorus diets over 21 days, and researchers will measure blood markers to f…

This study is testing whether artificial intelligence (AI) can analyze brain scans to help diagnose Parkinson's disease and related conditions like multiple system atrophy. Researchers will also see if the scans can predict how fast the disease will progress. The study involves 9…

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. Participants receive a harmless nutrient tracer during surgery or biopsy, and researchers collect blood and tissue samples to analyze cancer metabolism. The study does not change standard…

This early-phase study is testing whether a single dose of ketamine is safe for people with severe traumatic brain injury. Researchers will measure changes in brain pressure and oxygen levels in 10 critically ill adults. The goal is to see if ketamine, which has sedative and pain…

This study checks if a new PET-CT scanner (RefleXion X1) can see prostate cancer tumors as well as the standard scanner does. About 25 men with prostate cancer who are already getting a standard PET scan will get an extra scan on the new machine. The goal is to see if the new sca…

This study is tracking 50 adults with a heart condition called ATTR-CM to see if medications like tafamidis or acoramidis lower harmful amyloid proteins in the blood over time. Researchers will take blood samples at several visits to measure these proteins. The goal is to find ou…

This study looks at how Parkinson's disease affects the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks while on their usual dopamine medication. The goal is to better understand these brain …

This study aims to collect genetic and protein data from 1,000 people with lupus-related skin disease. Researchers hope to identify the genes and proteins that cause skin lesions in lupus. The goal is to better understand the disease, improve diagnosis, and spark new drug develop…

This pilot study will test whether a stellate ganglion nerve block—a procedure used for chronic pain—can improve blood flow in the tiny vessels of the eye. Researchers will use a special camera (OCTA) to scan the retinas of 50 adults before and after the block. The goal is to see…

This long-term study follows up to 50,000 people with multiple sclerosis to learn how the disease changes over time and what factors affect it. Participants fill out surveys twice a year online or by mail. No treatment or medication is given; the goal is to gather information for…

This study tests whether water spray, fans, or both can reduce heat-related stress on the heart and body in older adults. One hundred healthy volunteers aged 65 and older will sit in a hot climate chamber while researchers measure their temperature and heart function. The goal is…

This study looks at whether two common heart medications, propranolol and metoprolol, cause older adults to get hotter than normal during extreme heat. Researchers will measure body temperature and sweat rate in 22 healthy volunteers aged 65 and older over 3 hours of heat exposur…

This study will collect pupil measurements from 1,000 patients in the neuro-intensive care unit using a device called a pupillometer. The goal is to establish what normal pupil size, reactivity, and neurological pupil index values are for critically ill patients. By gathering thi…

This early-phase study investigates how scopolamine, a drug known to affect memory, changes brain activity in people with epilepsy who are already undergoing brain monitoring for seizures. Sixty participants will receive either scopolamine or a placebo and perform memory tasks wh…

This study looks at whether offering money for things like travel, lodging, and childcare helps more people from different backgrounds join cancer clinical trials. Researchers will track enrollment and retention of 1,200 patients who are already in a cancer trial. They will compa…