Sugar pill may stop recurrent UTIs without antibiotics

NCT ID NCT06940622

Recruiting now Prevention Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether taking D-mannose, a natural sugar, daily for a year can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo in 90 women who have had multiple UTIs. The goal is to see if this supplement reduces UTI episodes and the need for antibiotics.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-mannose (a dietary supplement)
What this could lead to: If it works, this could offer a simple, non-antibiotic way to prevent recurrent UTIs in older women.
What could go wrong: This is a small, early-stage trial with only 90 participants. D-mannose may not work better than placebo, and results may not apply to all women.

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Conditions

The condition(s) this trial relates to.

bacterial urinary tract infection chronic cystitis cystitis urinary tract infection urinary tract infections, recurrent, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTITIS CHRONIC CYSTITIS RECURRENT RECURRENT URINARY TRACT INFECTION RECURRENT URINARY TRACT INFECTIONS RECURRENT URINARY TRACT INFECTIONS IN WOMEN RECURRENT UTIS UTI UTI - LOWER URINARY TRACT INFECTION UTI - URINARY TRACT INFECTION

Contacts and locations

Locations

University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

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