University Of Texas Southwestern Medical Center

This study looks at two ways to manage frequent bladder infections in women: taking a daily antibiotic (nitrofurantoin) alone, or combining it with a procedure that burns away tiny infection spots in the bladder (electrofulguration). The goal is to see which approach better preve…

This study compares two treatments for early-stage non-small cell lung cancer in patients who are high-risk for surgery: a less invasive surgery called sublobar resection versus a precise type of radiation therapy called stereotactic ablative radiotherapy (SAbR). The goal is to s…

This study is for children whose solid tumors have come back or not responded to standard treatment. It combines the immunotherapy drug atezolizumab with three chemotherapy drugs to see if the combination is safe and can shrink tumors. About 23 children will take part in this ear…

This study looks at whether a community program that teaches families about healthy eating, physical activity, and sleep can help children who are overweight or obese. About 160 children will be randomly assigned to either join the program right away or be placed on a waitlist. T…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This study tests whether escitalopram, an antidepressant, can lower the number of severe asthma attacks in adults with moderate to severe asthma who have had at least three attacks in the past year. Participants will take either escitalopram or a placebo for a period, and researc…

This early-phase trial tests a new way to give radiation therapy for locally advanced rectal cancer. The goal is to see if giving higher doses of radiation in a shorter time, along with chemotherapy, can destroy the tumor enough to avoid surgery. About 27 adults with stage T3-4 o…

This study tests whether a higher dose of the drug cabozantinib can help people with advanced kidney cancer whose disease got worse while on the standard dose. About 18 adults whose cancer had been controlled by cabozantinib for at least 6 months will receive a higher dose. The g…

This study tests whether orlistat, a drug usually used for weight loss, can safely lower extremely high blood triglycerides in people with Type 1 hyperlipoproteinemia (familial chylomicronemia syndrome). About 28 participants aged 8 and older with confirmed genetic mutations will…

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…

This study tests a new way to treat early-stage ER+ breast cancer using a single, strong dose of radiation before surgery. It also explores using a special ultrasound with microbubbles to check lymph nodes without a surgical biopsy. The goal is to see if this approach can elimina…

This study looks at whether HIV-positive patients with advanced heart failure can safely receive heart transplants from HIV-positive donors. About 50 participants will be followed for three years after transplant. The goal is to see if using HIV-positive donor hearts is as effect…

This study looks at whether telemedicine can help new mothers from lower-income backgrounds get faster care for problems like high blood pressure, infections, or blood clots after giving birth. About 3,500 women will be split into two groups: one using telemedicine and the other …

This study tests a personalized approach to radiation therapy for men whose prostate cancer has returned after surgery. Instead of giving everyone the same treatment, doctors will adjust the plan based on how well the cancer responds to initial radiation. Those who respond well m…

This study looks at how vitamin D levels relate to sarcoidosis severity and whether giving vitamin D to patients with low levels can improve lung function and quality of life. About 90 adults with stable sarcoidosis will take either standard vitamin D supplements or a placebo for…

This study tests whether a short course of intravenous ketamine can help adults with moderate to severe methamphetamine use disorder reduce their drug use. 120 participants will receive either ketamine or a placebo (midazolam) over six weeks, and researchers will check urine samp…

This study tests whether hydroxycitrate, a molecule similar to citrate, can help prevent calcium phosphate kidney stones from coming back. Researchers will measure how well the treatment works in 25 adults who have had these stones before. The goal is to find a new way to control…

This study tests a combination of a targeted drug (enfortumab vedotin) and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for patients who cannot receive standard chemotherapy with cisplatin. The goal is to see if this approach is safe and can el…

This study tests whether two experimental drugs, ligufalimab and cadonilimab, can shrink or control advanced liver and bile duct cancers that have not responded to previous treatments. About 64 adults will receive the drug combination to see if tumors reduce in size. The goal is …

This study tests whether adding an immune-boosting drug (IMSA101) and targeted radiation to standard immunotherapy can help control metastatic kidney cancer that has started to grow again. About 15 adults with clear cell kidney cancer that has progressed in up to 5 spots will rec…

This study tests a program to help blood donors who have a genetic condition that causes very high cholesterol (familial hypercholesterolemia) get better treatment. About 100 adults aged 18 to 75 who are not currently on cholesterol medication will take part. The program includes…

This study tests whether the antipsychotic clozapine works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar I with psychosis, based on a specific brain biotype (B1). About 524 adults will be randomly assigned to receive either drug for 1…

This early-phase study tests whether blocking nerve signals to the prostate can slow or stop the spread of high-risk prostate cancer. Researchers will give one or two injections of a nerve-blocking agent before surgery to see if it reduces nerve activity around the tumor. The stu…

This study tests whether text messages can help parents lock up guns and medications after their teen's suicide-related emergency room visit. About 129 teens aged 12-17 and their parents will be followed for 12 weeks. The goal is to see if simple reminders can reduce access to da…

This study tests whether two drugs, lenvatinib and pembrolizumab, can slow tumor growth in people with cervical cancer that has spread or come back. About 30 adults with certain types of cervical cancer will receive the combination. The goal is to see if the treatment shrinks or …

This study tests whether giving a single dose of a special radiation drug (131I-Apamistamab) before standard CAR-T cell therapy can safely improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 30 adults will participate to check safety and h…

This study tests INTACS prescription inserts—tiny plastic implants placed in the cornea—to reduce vision problems caused by keratoconus, a condition that thins and bulges the cornea. About 25 adults who can no longer see well with glasses or contacts and are facing a corneal tran…

This study is testing temporary nerve implants in people with hand or arm amputations to see if they can improve control of prosthetic hands and restore natural sensations. About 25 adults will receive small electrodes placed around nerves in the arm for about 18 months. Research…

This study looks at bone health in up to 100 people with and without cystic fibrosis (CF) using scans and blood tests. A smaller group of CF patients with bone disease will receive denosumab, a drug that helps strengthen bones, for up to 5 years. The goal is to see if this treatm…

This study tests a personalized approach to radiation therapy for high-risk prostate cancer. Using special PET scans that highlight cancer cells, doctors will adjust the timing and dose of radiation to each patient's tumor. The goal is to improve treatment effectiveness while red…

This study tests whether combining three standard heart medications (aspirin, a blood thinner, and a statin) into a single daily pill helps people who've had a heart attack take their medicine more consistently. About 1,000 adults who recently had a heart attack and a stent place…

This study looks at two treatments for mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers want to see if removing the adrenal gland (surgery) or taking semaglutide (a weight-loss drug) better improves insulin resistance and …

This study looks at whether cooling therapy helps babies born with mild brain injury (HIE) develop better as they grow. About 460 full-term newborns will be enrolled within 6 hours of birth. Researchers will compare cooling to standard care and measure development at age 2, as we…

This study tests a drug called belantamab mafodotin in people with a rare blood disease called AL amyloidosis that has come back or not responded to other treatments. The goal is to find the safest and most effective dose. The study has two parts: first, different doses are teste…

This study tests personalized radiotherapy approaches for people with lung cancer, brain metastases, or other solid tumors. It aims to see if adapting radiation based on how a patient responds is safe and effective. About 45 adults will participate, receiving either extra radiati…

This study tests whether a 12-week home-based cardiac rehabilitation program delivered through a smartphone app can help people with heart failure live longer, avoid hospital stays, and feel better. The program is designed for patients who cannot attend in-person rehab, especiall…

This early-stage trial tests a gene therapy injected directly into the left vagus nerve for people with giant axonal neuropathy (GAN), a rare and fatal nerve disease. The study enrolls 4 participants who previously received the same gene therapy via spinal injection. The main goa…

This study is testing ablative therapies—treatments that destroy cancer cells with heat or cold—for men with localized prostate cancer. Researchers want to see how well these treatments control cancer and affect quality of life, including urinary and sexual function. The study wi…

This early-stage study tests a personalized radiation technique called PULSAR for lung cancers located near the center of the chest. The goal is to make treatment safer while still effectively controlling the tumor. About 30 adults with primary or metastatic lung cancer will rece…

This study is for people with head and neck cancer. It compares two types of radiation therapy: one that treats only the cancer and nearby lymph nodes (INRT) and one that treats a larger area (ENI). The goal is to see if the smaller treatment area works just as well and causes fe…

This study tests a fluorescent dye called pegsitacianine that makes cancer cells glow during surgery. About 120 adults with head and neck cancer will receive one dose before their operation. Doctors will use special cameras to see if the dye helps find tumors that are hard to spo…

This study is testing whether a simple urine test every 6 months for 2 years can find bladder cancer earlier in people at high risk. Participants must be 50 or older with a heavy smoking history or long-term exposure to certain workplace chemicals. The goal is to see if routine s…

This study tests whether an AI tool can help doctors find undiagnosed heart failure in people with type 2 diabetes. About 800 participants will have their heart ultrasound results analyzed by the AI, and doctors will get alerts suggesting preventive medications. The goal is to st…

This study tests a new type of MRI that uses a safe, natural substance to measure how well the heart is producing energy. By looking at two simple molecules, the scan can tell which parts of the heart are still alive and working. The goal is to help doctors decide who will benefi…

This study tests whether taking D-mannose (a natural sugar) daily can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Participants will take either D-mannose or a placebo for 12 months. The goal is to see if D-mannose reduces the numb…

This study aims to help people who are at risk for HIV start prevention medication (PrEP) right away in the emergency department. Participants will receive a same-day prescription for oral PrEP and a follow-up appointment to continue care, with options for long-acting injectable …

This study tests a new way to prevent heart failure in people with type 2 diabetes. Doctors will use a blood test (NT-proBNP) and a risk score to find high-risk patients, then start them on proven preventive medications. The goal is to see if this approach reduces heart failure a…

This study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.

This study tests whether a compound found in green tea, EGCG, can lower the risk of liver cancer in people with liver cirrhosis. About 60 adults with cirrhosis but no prior liver cancer will take either EGCG or a placebo for several months. Researchers will measure changes in a b…

This study looks at whether regularly heating the legs with a portable sauna blanket can improve blood vessel health and lower the risk of high blood pressure disorders in pregnant women with obesity. About 118 women will be randomly assigned to either a warm blanket (65°C) or a …

This study tests a program to help people in Dallas County Jail access PrEP, a daily pill that prevents HIV. A navigator will meet with interested inmates to discuss HIV risk, offer testing, and connect them to PrEP providers after release. The goal is to see if this approach inc…

This study tests whether helping older adults (70+) with high blood pressure get better control of their numbers can also protect their memory and thinking skills. Researchers will compare a special care program (with decision support and team-based care) to usual care. The goal …

This study tests whether adding a peer health coach to existing re-entry services can help people with a history of justice involvement learn about and start taking PrEP, a daily pill that prevents HIV. Researchers will work with 100 clients of Unlocking Doors in Dallas to see if…

This study looks at how to improve laser therapy for port-wine birthmarks in children. The goal is to reduce the number of treatments needed and make the therapy work better, especially for stubborn cases. About 200 children aged 2 months to 18 years will take part. Researchers w…

This study tests whether keeping the skin wet—by wearing a damp T-shirt or wetting the skin—can help people with heart failure stay cooler and reduce stress on the heart during extreme heat. About 88 participants (half with heart failure, half healthy) will be exposed to simulate…

This study tests a new approach for people with a chronic cough that hasn't responded to other treatments. Doctors will apply a freezing treatment (cryotherapy) to the throat to see if it reduces coughing and improves quality of life. The study will follow 28 adults for 6 months …

This study tests whether a mobile phone app can help people with kidney problems better control body swelling by guiding daily adjustments to their water pill (diuretic) dose. About 30 participants will use the app for 90 days, entering their weight and blood pressure daily. The …

This study compares a nasal spray painkiller (ketorolac) to a standard oral pill (diclofenac) for pain caused by ureteral stents placed after kidney stone surgery. Researchers want to see if the nasal spray works faster and reduces the need for extra doctor visits. The study will…

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study tests whether wetting the skin can prevent dangerous rises in body temperature during exercise in hot conditions for burn survivors. Researchers will compare cooling methods in 40 adults, including those with and without burn injuries. The goal is to find a simple way …

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can reduce certain autism symptoms, such as repetitive behaviors and hyperactivity, in children and young adults aged 4 to 17. Researchers will apply a mild electrical current to a part of the b…

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find the safest w…

This study tests whether a remote exercise training program can improve exercise capacity and quality of life in 120 adults with heart failure with preserved ejection fraction (HFpEF) or those at risk for it. Participants will follow a tailored exercise plan from home using a mob…

This small pilot study is testing whether a gentle, non-invasive brain stimulation technique called tDCS, applied to the cerebellum, can help improve social behaviors and thinking flexibility in women and girls with anorexia nervosa. The study involves 15 participants aged 15-30 …

This study tests a non-invasive ear stimulation device (tAN) to see if it can lower pain and the need for opioid painkillers after lumbar spine surgery. About 20 adults undergoing back surgery will receive either the active device or a placebo. The goal is to find a safer, drug-f…

This study tests whether an online recovery program with trained teen peers and support specialists can help teens aged 15-18 who recently left a psychiatric hospital after suicidal thoughts or attempts. Participants are split into two groups: one gets the online program plus sta…

This study compares three breathing treatments (IPPB, EzPAP, and Metaneb) to see which one helps lungs expand and recover best after heart surgery. About 324 adults who had coronary bypass or valve surgery will take part. The goal is to find the most effective therapy to improve …

This study tests whether a low dose of colchicine, a drug usually used for gout, can help people with a certain type of heart failure (HFpEF) and inflammation exercise more easily. About 60 adults aged 50 and older will be randomly assigned to take either colchicine or a placebo …

This study looks at whether teaching social skills can improve symptoms in 60 young adults (ages 18-30) with eating disorders and anxiety. Participants will either get education alone or education plus an interactive group art activity. Researchers will track changes in eating, m…

This study compares a newer, shorter course of radiation therapy (hypofractionated) with standard radiation for people with early-stage laryngeal cancer. The goal is to see which approach causes fewer side effects during and shortly after treatment. About 67 adults with stage 0 t…

This study tests a treatment called transcutaneous tibial nerve stimulation (TTNS) for children aged 8-18 with spina bifida who still leak urine despite regular catheter use. TTNS uses mild electrical pulses at the ankle to stimulate a nerve that helps control the bladder. Partic…

This study looks at whether an FDA-approved automated device can safely drain small amounts of spinal fluid in older adults (60+) with normal pressure hydrocephalus. The device monitors pressure continuously and aims to reduce human error and improve patient comfort. Ten particip…

This study is a long-term registry for adults diagnosed with multiple sclerosis (MS) or clinically isolated syndrome. Participants fill out surveys twice a year about their health, lifestyle, and treatments. The information is used only for research to better understand how MS pr…

This study aims to understand how brain tumors use sugar (glucose) for energy by giving patients a special, non-radioactive form of glucose during surgery. Researchers will analyze the tumor tissue and compare it with MRI scans and genetic information. The goal is to find better …

This study looks at the best way to share personalized heart health information with 1500 adults from the Dallas Heart Study. Participants will receive letters with their heart risk results, presented either in a detailed or simple format. Researchers will track whether people wa…

This study looks at how a simulated burn injury affects the body's ability to cool down after exercise in hot conditions. Researchers will apply a special material to the skin to mimic a burn and measure core temperature and heart rate during recovery. The goal is to understand i…

This study will enroll 5500 adults with liver cirrhosis or chronic hepatitis B to compare two screening methods for liver cancer. Half will get standard ultrasound plus a blood test (AFP) every six months, and the other half will get a newer blood test (GALAD) alone. The goal is …

This study looks at how the body handles phosphate in people with chronic kidney disease (stages 3-4). Researchers want to find new ways to measure phosphate overload using blood tests and create a simple index. 60 adults with and without kidney disease will eat controlled meals …

This study looks at how Parkinson's disease affects the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks while on their usual dopamine medication. The goal is to better understand these brain …

This study collects data from 1,000 intensive care patients to determine normal pupil size and reactivity using a pupillometer device. The goal is to help doctors better understand what healthy pupil readings look like in critically ill people. Participants are adults already rec…

This study tests a new device that measures pressure inside the skull without surgery. It uses a tiny pin on the head to detect skull movements from heartbeats. Researchers will compare its readings to standard invasive methods in 30 adults already undergoing brain surgery or rel…

This study looks at whether two common heart medications, propranolol and metoprolol, cause older adults to get hotter than normal during extreme heat. Researchers will measure body temperature and sweat rate in 22 healthy volunteers aged 65 and older over 3 hours of heat exposur…

This study looks at how natural changes in the hormone estradiol affect the spinal cord's ability to adapt in healthy young women and men. Researchers will use mild electrical stimulation to measure spinal cord responses. The goal is to understand basic biology, not to treat any …

This study uses a special MRI technique to see how brain tumors use energy. Researchers will scan 25 adults with brain tumors before treatment. The goal is to learn more about tumor metabolism, not to treat the disease.

This study is a large registry that collects health information from up to 10,000 people who received or were evaluated for radiation therapy at UT Southwestern since 2000. Researchers will analyze quality of life and compare outcomes with national data to better understand the b…

This study looks at whether offering money for things like travel, parking, and childcare helps more people from different backgrounds join and stay in cancer clinical trials. About 1,200 adults already in a cancer trial can take part. Researchers will compare those who use the f…

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. Participants receive a harmless nutrient tracer during surgery or biopsy, and researchers collect blood and tissue samples to analyze cancer metabolism. The study does not change standard…

This study tests whether a combined PET/MR scan can better distinguish aggressive kidney cancers from slow-growing or benign tumors. About 97 adults with suspicious kidney masses will receive an extra PET scan during their routine MRI. The goal is to reduce unnecessary surgeries …

This study measures levels of amyloid proteins in the blood of 50 adults with transthyretin amyloid cardiomyopathy (ATTR-CM) who are taking standard TTR-stabilizing medications like tafamidis or acoramidis. Researchers want to see if these drugs lower amyloid levels over three mo…

This study aims to improve early detection of mental health issues in children (ages 7-21) who have a parent with bipolar disorder. Researchers are testing a video decision aid to help parents understand genetic risks and make informed choices about screening their kids. The stud…

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

This study uses advanced brain imaging and artificial intelligence to find patterns that can help doctors tell the difference between Parkinson's disease and similar disorders like multiple system atrophy. Researchers will also look for brain markers that predict how fast the dis…

This study looks at how a single dose of ketamine affects brain pressure and oxygen levels in 10 adults with severe traumatic brain injury. Researchers want to see if ketamine, a drug that provides sedation and pain relief, is safe and helpful for these patients. Participants mus…

This study looks at how melanoma tumors use energy (sugar) to grow and spread. Researchers will give a special sugar infusion during surgery to track it in the tumor. 400 adults with melanoma will join to help find clues about which tumors are more likely to spread.

This study follows 200 adults with Multiple System Atrophy (MSA) to see if care from a team of specialists improves their quality of life and eases the burden on caregivers. Participants will fill out questionnaires every four months about their daily activities and well-being. T…

This study looks at whether breathing problems make it harder for people with heart failure and obesity to exercise. Researchers will measure how much oxygen breathing takes and test if a special gas mixture helps with shortness of breath and exercise ability. The goal is to unde…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study looks at how a drug called scopolamine affects brain areas involved in memory. Sixty adults with epilepsy who are already having brain surgery for seizure monitoring will take part. They will receive either the drug or a saltwater solution and perform memory tasks whil…

This study looks at whether a brain treatment called focused ultrasound can reduce the social stigma that people with essential tremor often face. About 220 adults with essential tremor will have their tremor treated and then be followed for one year. Researchers want to see if l…

This study looks at how two drugs, sirolimus and everolimus, work in healthy adults aged 65 and older. Researchers want to measure how the body processes these drugs and their effects on aging-related markers. The goal is to gather essential data to design future trials that coul…

This study aims to understand how lung tumors burn sugar for energy by using a special MRI scan and a natural sugar solution. About 200 adults with suspected lung cancer will receive the sugar solution before surgery, and their tumor tissue will be analyzed. The goal is to learn …

This study aims to collect genetic information from 1,000 people with lupus-related skin disease (cutaneous lupus) to find the genes and proteins that cause it. By understanding these genetic factors, researchers hope to improve diagnosis, predict disease course, and develop new …

This study is testing whether a mild electrical current applied to the spine (called tsDCS) can improve reflexes, walking, and balance in people who have had a stroke. About 100 adults who had a stroke more than 6 months ago and still have weakness on one side will attend 15 sess…

This study creates a registry for children and adults with morphea (localized scleroderma) to track how the disease changes over time, what problems it may cause (like arthritis), and whether it is autoimmune. Researchers will collect health data and blood samples from 500 partic…

This study aims to develop a new imaging technique using a special substance called hyperpolarized pyruvate to measure how the brain uses energy and makes neurotransmitters. Researchers will scan 28 healthy adults aged 18 to 60 to create detailed maps of brain metabolism. This is…

This study is building a special bank of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait. Researchers will use these samples, along with medical records, to learn how kidney disease starts and gets worse in people with the sickle cell gene. T…

This study looks at CT scans from 2,000 people to see if computer models can better predict how lung cancer will respond to treatment. Researchers will review past patient records and data from a national screening trial. The goal is to improve screening and treatment decisions f…

This study tests how well different cooling methods (like cold towels or fans) protect the heart and body of healthy older adults during simulated heat waves. Researchers will measure body temperature and heart function in 100 volunteers aged 65 and older. The goal is to find sim…

This study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…

This study looks at whether eating too much phosphate—common in many US diets—can reduce your ability to exercise and increase belly fat. Researchers will measure oxygen use during cycling and energy production in muscles. About 124 healthy adults will take part to see if finding…

This study checks if a new PET-CT scanner (RefleXion X1) can see prostate cancer tumors as well as the standard scanner does. About 25 men with prostate cancer who are already getting a standard PET scan will get an extra scan on the new machine. The goal is to see if the new sca…

This study looks at how a nerve block (stellate ganglion block) changes tiny blood vessels in the eye. Researchers will use a special camera to take pictures of the retina before and after the procedure in 50 adults who are already receiving the block for pain. The goal is to und…