University Of Texas Southwestern Medical Center

This study compares two ways of caring for new mothers after they leave the hospital: telemedicine (video or phone visits) versus standard in-person clinic visits. The goal is to see which approach helps find and treat problems like high blood pressure, wound infections, or blood…

This study tests a combination of a targeted drug (enfortumab vedotin) and radiation therapy given before surgery for muscle-invasive bladder cancer. It is for patients who cannot receive standard chemotherapy with cisplatin. The goal is to see if this approach is safe and can el…

This study looks at whether taking a daily antibiotic (nitrofurantoin) alone works as well as combining it with a procedure that burns off tiny bladder sores (electrofulguration) to prevent repeat urinary tract infections in women. About 104 women aged 18-85 with frequent UTIs wi…

This study tests whether a low dose of ketamine, given through an IV, can help adults with moderate to severe methamphetamine use disorder reduce their drug use. 120 participants will receive either ketamine or a placebo over six weeks, and researchers will check urine samples to…

This early-stage trial tests a gene therapy injected directly into the left vagus nerve for people with giant axonal neuropathy (GAN), a rare, fatal nerve disease that affects movement, breathing, and automatic body functions. The study enrolls 4 participants who have already rec…

This study compares two treatments for early-stage non-small cell lung cancer in patients who are at high risk for surgery. One group will have a small part of the lung removed (sublobar resection), and the other will receive targeted radiation (stereotactic ablative radiotherapy…

This study tests whether nurse home visits help people with high blood pressure and type 2 diabetes manage their conditions better than standard clinic visits. Researchers will enroll 100 adults aged 18-60 who speak English or Spanish. They will measure changes in blood pressure …

This study is testing ablative therapies—treatments that destroy cancer cells using heat, cold, or other methods—for men with localized prostate cancer. Researchers will track how well these treatments control cancer, and how they affect urinary and erectile function. The goal is…

This study tests whether a higher dose of the drug cabozantinib can help people with advanced kidney cancer whose disease has gotten worse while on the standard dose. About 18 adults will receive the higher dose to see if it slows cancer growth. The goal is to control the cancer,…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can slow or stop tumor growth in women with cervical cancer that has returned or spread. About 30 participants will receive the treatment to see if tumors shrink or stabilize. The goal is to find a better…

This early-phase study tests a personalized radiation approach for high-risk prostate cancer. It uses special PET scans to see how tumors respond to hormone therapy, then adjusts the radiation dose to target remaining cancer spots. The goal is to improve treatment precision and r…

This study tests whether a single, strong dose of radiation given before surgery can eliminate early-stage ER+ breast cancer tumors. About 53 women will receive the radiation, and if the tumor disappears on scans and biopsy, they may avoid surgery. The study also explores using a…

This study looks at whether a 9-week dietician-guided program, adapted from the National Diabetes Prevention Program, can reduce body fat and improve how the body uses insulin in people with chronic spinal cord injury. Twenty adults who use wheelchairs will participate in telehea…

This study tests whether combining two drugs, ligufalimab and cadonilimab, can shrink advanced liver or bile duct cancers that have stopped responding to previous treatments. About 64 adults will receive the combination and be monitored for tumor response. The goal is to see if t…

This study is for people who have had a heart transplant due to ATTR amyloidosis, a disease that causes abnormal protein buildup. Even after a new heart, the disease can still damage nerves and the digestive system. Researchers want to see if the drug tafamidis can safely slow or…

This study tests a new type of MRI that looks at how the heart uses energy. It aims to help doctors decide which patients with blocked arteries and heart failure will benefit most from bypass surgery. About 30 adults with heart disease and healthy volunteers will get this special…

This study is testing whether helping people aged 70 and older keep their blood pressure under control can prevent memory loss and dementia. Researchers will compare a special care program (with decision support and team-based care) to usual care. About 4,000 participants with hi…

This study tests a new way to prevent heart failure in people with type 2 diabetes. Doctors will use a blood test (NT-proBNP) and a risk score to find high-risk patients, then start proven preventive medicines early. The goal is to see if this approach reduces heart failure or de…

This study tests whether a home-based exercise program can improve exercise capacity and quality of life in 120 adults with heart failure with preserved ejection fraction (HFpEF) or those at risk. Participants will follow a remote exercise plan and be compared across four lifesty…

This study looks at three different breathing treatments (IPPB, EzPAP, and Metaneb) to see which one helps lungs expand and recover best after heart surgery. About 324 adults who had coronary bypass or valve surgery will take part. The goal is to find out which therapy improves l…

This study looks at whether eating too much phosphate—a common additive in processed foods—can reduce your ability to exercise and increase belly fat. Researchers will measure oxygen use during cycling and muscle energy levels in 124 healthy adults. The goal is to see if findings…

This study is looking for 90 adults with Parkinson's disease or similar conditions (like multiple system atrophy or progressive supranuclear palsy) to test whether brain scans combined with artificial intelligence can help doctors tell these diseases apart and predict how fast th…

This study is testing whether a mild electrical current applied to the spine (called tsDCS) can improve leg reflexes, walking, and balance in people who have leg weakness after a stroke. About 100 adults who had a stroke more than 6 months ago will attend at least 15 sessions ove…

This study uses a special MRI technique to see how brain tumors use energy. Researchers want to learn more about tumor metabolism, not to treat the disease. About 25 adults with brain tumors will have one extra scan to help scientists understand these cancers better.

This study collects health information from up to 10,000 people who received or were considered for radiation therapy at UT Southwestern since 2000. Researchers will compare outcomes like quality of life and side effects to national data. The goal is to learn which patients benef…

This study follows a large group of people with multiple sclerosis over many years to understand how the disease changes and what factors affect it. Participants simply fill out surveys online or by mail twice a year. No treatments or tests are involved—just sharing information t…

This study looks at how well the body cools down after exercise in hot conditions when part of the skin is covered to mimic a burn injury. Researchers will compare the same person with and without this simulated burn to see if recovery is slower. The goal is to understand tempera…

This study looks at how the drug scopolamine changes brain activity related to memory. Researchers will work with 60 epilepsy patients who already have brain electrodes implanted for seizure monitoring. Participants will do memory tasks after receiving either scopolamine or a pla…