University Of Texas Southwestern Medical Center

This early-phase study tested a drug called abiraterone acetate (normally used for prostate cancer) in 4 children with congenital adrenal hyperplasia (CAH). The goal was to see if it could lower high male hormone levels and reduce the need for strong steroid medications that can …

This study aimed to compare two standard treatments for people with large, intermediate-stage liver cancer that cannot be surgically removed. One group received a combination of immunotherapy (atezolizumab) and targeted therapy (bevacizumab), while the other group received a loca…

This study tested a combination of the immunotherapy drug durvalumab and two different types of targeted radiation for people with advanced non-small cell lung cancer. The goal was to see if the treatment improved quality of life and controlled tumor growth. The trial was stopped…

This study looked at whether Hiprex, a medication that turns into formaldehyde in the urine, can help women aged 50-85 who get frequent urinary tract infections (UTIs). The goal was to see if it lowers the number of infections and reduces the need for antibiotics over one year. T…

This study tested whether meal replacements and behavioral treatments can help people maintain weight loss after stopping GLP-1 medications like Wegovy or Ozempic. It enrolled 39 adults with obesity who had lost at least 10% of their body weight on these drugs and had stopped the…

This study tested whether a wearable device and digital care plan could help people with systolic heart failure get better medical treatment. The plan was to enroll 150 adults, but the study was stopped early. Participants would have used the device for 90 days to track their hea…

This study looked at how the brain loses and regains consciousness during anesthesia in people with Parkinson's disease or essential tremor. Researchers recorded brain activity during deep brain stimulation surgery and tested responses to sounds and commands. The goal was to bett…

This study looked at how heat waves impact body temperature and lung function in people aged 65 and older with COPD. Researchers measured core temperature and breathing tests. Only one person took part before the study was stopped.

This study looked at whether a special MRI technique called Arterial Spin Labeling (ASL) could detect changes in blood flow to kidney cancer tumors soon after starting treatment. It involved 6 people with advanced kidney cancer who had up to 6 MRI scans over 7 months. The study w…

This study tested whether a special type of MRI can detect early signs of heart damage caused by radiation therapy. It included people with left-sided breast cancer or other chest cancers receiving standard radiation. The goal was to see if changes in heart cell energy use could …