University Of Texas Southwestern Medical Center

This study looks at whether the drug tafamidis can safely stop the progression of ATTR amyloidosis in people who have already had a heart transplant for the disease. About 25 participants will take tafamidis for 12 months. The goal is to see if it stabilizes a key protein in the …

This study tests whether semaglutide, a once-weekly injectable diabetes drug, improves blood sugar control in people with type 2 diabetes who are on chronic dialysis. About 43 participants will be randomly assigned to receive either semaglutide or a placebo for about 13 months. T…

This study looks at whether switching from natalizumab to cladribine tablets is safe and effective for people with relapsing forms of multiple sclerosis. About 40 adults aged 18-60 will take cladribine after stopping natalizumab. Researchers will track immune cell changes, relaps…

This study tested whether combining two drugs, afatinib and prednisone, can help people with advanced squamous non-small cell lung cancer who have already tried other treatments. The goal was to see if the combination could slow cancer growth. The trial enrolled 12 adults and mea…

This study tests a highly targeted radiation technique called stereotactic partial breast irradiation (S-PBI) given over 5 sessions for women with early-stage breast cancer. The goal is to see if this approach improves cosmetic outcomes while controlling the cancer. About 74 wome…

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This study tests giving focused radiation to a tumor clot in the main vein before surgery for kidney cancer. The goal is to see if this approach is safe and helps prevent the cancer from coming back within a year. About 25 people with newly diagnosed kidney cancer and a clot in t…

This study tests a precise, high-dose radiation method called SABR for men with high-risk prostate cancer. The goal is to find the highest safe dose to the prostate and pelvic lymph nodes while monitoring side effects and quality of life. About 60 participants will receive up to …

This early-phase study tests a single, powerful dose of radiation given before surgery for early-stage breast cancer. The goal is to find the highest safe dose that can destroy the tumor. About 45 women with small breast tumors (3 cm or less) will receive one of three radiation d…

This study tests whether Tofacitinib, a drug used for arthritis, can slow tumor growth in people with recurrent glioblastoma (a type of brain cancer). About 17 adults whose cancer returned after standard treatment will take Tofacitinib pills twice daily. The goal is to see if it …

This study tests whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without using whole-brain radiation. It involves 135 adults with up to 10 brain metastases from solid tumors. The goal is to find the highest safe …

This study tests whether adding a precise type of radiation (SABR) to the targeted drug osimertinib can help people with advanced EGFR-mutant lung cancer live longer without their disease getting worse. About 41 adults with this specific genetic type of lung cancer will receive b…

This study tests a precise, non-invasive radiation treatment called SABR for small kidney tumors that are growing. Sixteen adults with biopsy-proven renal masses up to 5cm received this focused radiation to see if it can stop tumor growth and kill the cancer cells. The goal is to…

This study tests whether a new type of cage (with nanoLOCK coating) used in neck fusion surgery leads to better swallowing and bone healing than standard cages. About 200 adults with neck nerve problems will be randomly assigned to get either the new cage or a regular one. The go…

This study tests an automated tool that uses patient risk levels to remind people with inflammatory bowel disease (IBD) when they need follow-up appointments. Researchers will compare how often patients are overdue for visits and whether this leads to fewer emergency room trips o…

This study tests whether freezing the tumor (cryoablation) combined with an immunotherapy drug before surgery can help prevent breast cancer from coming back in women with triple-negative breast cancer. About 51 women who still have cancer after initial chemotherapy will receive …

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk can increase the number of people who get tested for type 2 diabetes. Researchers will compare these tailored invitations to generic ones and to usual care. …

This study tests whether a precise type of radiation (SAbR) that avoids the nerves near the prostate can help men with localized prostate cancer keep their ability to have erections. About 124 men will be randomly assigned to standard SAbR or a nerve-sparing version. The goal is …

This study aimed to help bladder cancer patients recover after surgery by using a program that monitors them before, during, and after the operation. The goal was to lower the chance of problems like complications and readmissions. However, the study was withdrawn before any part…

This study tests a shorter, more intense radiation schedule after surgery for head and neck cancer. The goal is to see if it causes fewer swallowing problems and is safe. About 59 adults with certain types of head and neck cancer are taking part. The study has two phases: first t…

This early-phase study tests whether a special light therapy is safe and can help reduce fatigue in people with progressive multiple sclerosis. About 20 adults with this condition will receive the light treatment. The goal is to see if it is well-tolerated and to gather initial d…

This study looks at whether adding methadone to standard morphine pain medicine can better control severe mouth pain (mucositis) in children aged 6 to 18 who are getting a stem cell transplant for conditions like leukemia or aplastic anemia. The mouth pain happens because chemoth…

This study looks at whether a simple writing therapy called Written Exposure Therapy (WET) can help pregnant and postpartum teens and young adults (ages 15-24) with PTSD. The goal is to see if the therapy is easy to use and if it reduces PTSD symptoms. About 30 participants will …

This study looks at how bone may influence citrate levels in urine, which is important for kidney stone prevention. Researchers will study 25 people with osteoporosis who have not yet been treated. They will measure bone density and turnover, then give a citrate supplement to see…

This study follows 9 people with transverse myelitis who previously received an experimental cell therapy called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if the treatment continues to have any effect. Participants will have regular ex…

This study looks at how alcohol triggers the liver to make new fat in women compared to men. Healthy volunteers drink a special heavy water and a small amount of alcohol, then give blood samples to track fat production. The goal is to understand the process, not to treat any dise…

This study looks at how major depression changes the way people process emotions and make decisions, especially as they age. Researchers will compare 120 adults with depression to 120 healthy volunteers using brain scans and thinking tests. The goal is to better understand the br…

This study looks at how precise radiation (stereotactic radiosurgery) affects memory and thinking in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will take part to find the safest radiation dose and measure any decline in memory over 4 m…

This study follows 1,500 young people aged 10-24 for up to 10 years to learn what helps them stay mentally strong and avoid depression and anxiety. Researchers will look at things like lifestyle, brain scans, and personal history. No treatments or medications are given—this is pu…

This study looks at whether using a Pedi-Cap, a device that changes color to show carbon dioxide levels, can shorten the time newborns need breathing help in the delivery room. About 632 infants born at 30 weeks or later who need face mask ventilation will be included. The resear…

This study follows over 850 adults with cirrhosis who are getting a TIPS procedure—a small tube placed in the liver to relieve dangerous pressure. Researchers will track their health for 5 years to learn which patients benefit most and how to reduce side effects like confusion or…

This study follows 150 people with rare inflammatory conditions affecting the brain, spinal cord, and optic nerves. Researchers collect health data and biological samples over time to learn what causes inflammation, why some patients respond to treatment while others do not, and …

This study looks at whether healthcare providers can use skills learned on mannequins when helping real newborns breathe. About 120 respiratory therapists will be observed in both a simulation lab and the delivery room. The goal is to see if their ability to manage a baby's mask …

This study is creating a collection of blood samples and health information from 250 adults with very high or very low cholesterol or related lipid problems. Researchers will analyze these samples to learn more about the genetic and biological causes of these extreme lipid disord…

This study looks at why some children and teens feel short of breath or have trouble exercising after their first blood clot in the leg (deep vein thrombosis) or lung (pulmonary embolism). Researchers will measure exercise capacity and breathing using special tests. The goal is t…

This study looks at how social media use impacts the emotions of 100 teenagers (ages 13-18) who already have depression or suicidal thoughts. Participants will use a smartphone app to report their feelings and social media use twice a day for 30 days. The goal is to better unders…

This study is creating a large registry of 5,000 young people (ages 8-20) who have depression or suicidal thoughts. Researchers will track their health over time to better understand the condition and develop ways to predict outcomes. The goal is to improve care and support for y…

This study looks at how obesity affects children's lungs and ability to exercise as they grow older. Researchers will re-examine 90 children (some with obesity, some without) who were first tested between ages 8-12, about 6 years ago. The goal is to measure changes in lung functi…

This study looks back at the medical records of 20,000 people with lung or gastrointestinal cancer to learn more about cachexia—a condition where patients lose weight and muscle. Researchers want to see how doctors currently treat cachexia and how it affects patients' outcomes. N…

This study looks at how well people with short bowel syndrome tolerate dietary fiber, like green beans. Researchers will track symptoms, weight, and changes in gut bacteria. The goal is to understand if fiber can be safely added to their diet. 60 adults from UT Southwestern clini…

This study reviews medical records of 10,000 people with lung or gastrointestinal cancers to see if PET scans can identify tumors that cause cachexia—a condition of severe weight loss and weakness. Researchers will compare PET scan results with patients' weight and performance st…

This study looks at how extra body fat affects muscles and blood vessels in people with a type of heart failure called HFpEF. Researchers will measure muscle health and blood flow before and after participants lose at least 7% of their body weight using standard weight-loss medic…

This study aimed to compare two standard treatments for severe hemophilia A—extended half-life factor VIII and non-factor VIII therapies—to see which better protects joint health and controls bleeding. It was designed for children under 18 without existing joint damage. However, …

This study aims to understand how the brain regulates actions, especially in people with Parkinson's disease. Researchers will record brain activity from 125 patients during deep brain stimulation (DBS) surgery while they perform tasks involving decision-making, stopping, and swi…