University Of Texas Southwestern Medical Center

This study tests whether Tofacitinib, a drug used for arthritis, can slow tumor growth in people with recurrent glioblastoma (a type of brain cancer). About 17 adults whose cancer has returned after standard treatment will take Tofacitinib pills twice daily. The main goal is to s…

This study tests a new way to give radiation to early-stage breast cancer using a device called the GammaPod. Instead of many sessions, patients get just 5 precise doses aimed at the tumor while sparing healthy tissue. The goal is to see if this approach keeps the cancer from com…

This study looks at whether people with relapsing-remitting or active secondary progressive multiple sclerosis can safely switch from natalizumab to cladribine tablets. The goal is to see if cladribine can control the disease with fewer infusions. The study involves 40 adults age…

This early-phase study tests a special light therapy designed to reset the body's internal clock and reduce fatigue in people with progressive multiple sclerosis. About 20 adults with stable disease will receive the light treatment, and researchers will monitor safety and any cha…

This study looks at whether adding methadone to standard morphine-based pain relief can better manage severe mouth pain in children aged 6 to 18 who are undergoing a stem cell transplant for conditions like leukemia or aplastic anemia. The intense chemotherapy before transplant o…

This study follows 150 people with rare inflammatory conditions affecting the brain, spinal cord, and optic nerves. Researchers collect medical data and biological samples over time to understand what causes these diseases and why some patients respond to treatments while others …

This study looks at how the brain manages actions like stopping or switching tasks in people with Parkinson's disease. Researchers will record brain activity during deep brain stimulation (DBS) surgery in 125 patients. The goal is to understand the brain circuits involved, not to…

This study follows 852 adults with liver cirrhosis who are scheduled for a TIPS procedure, a shunt placed to reduce high blood pressure in the liver. Researchers will collect information from standard care to learn how to best use TIPS and manage its side effects. The goal is to …

This study looks at how depression changes the way people process emotions and make decisions. Researchers will compare 120 adults with major depression to 120 healthy volunteers, all aged 21 to 80. Participants will complete thinking tasks and brain scans to map emotional and co…

This study was designed to see if two different standard treatments for severe hemophilia A affect joint health and bleeding differently in children. Researchers planned to use ultrasound and blood tests to look for early joint changes. However, the study was withdrawn before enr…

This study looks at how extra body fat affects muscles and blood vessels in people with a type of heart failure called HFpEF. Researchers will measure changes before and after participants lose at least 7% of their body weight using standard weight-loss medications. The goal is t…