Can stronger, targeted radiation beat brain metastases without Whole-Brain side effects?
NCT ID NCT02645487
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without also radiating the whole brain. About 135 adults with certain types of cancer that have spread to the brain will receive escalating radiation doses based on tumor size. The goal is to find the highest tolerable dose that may improve tumor control and survival while preserving quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Stereotactic Radiosurgery (SRS)
- What this could lead to
- If successful, this could establish safer, more effective radiation doses for brain metastases, potentially improving local tumor control and survival without whole-brain radiation.
- What could go wrong
- This is an early dose-escalation study, so the highest doses may prove too toxic. The trial is also limited to patients with certain tumor types and no prior brain radiation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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