University Of Texas Southwestern Medical Center

This study tests whether giving two drugs (ateganosine and cadonilimab) before surgery can safely shrink liver tumors in people with resectable liver cancer. About 60 participants will receive either one or both drugs before their operation. The main goal is to see if the treatme…

This study tests whether a low dose of the drug erlotinib can prevent liver cancer in 60 adults with advanced liver fibrosis or cirrhosis. Participants will receive either erlotinib or a placebo for a set period. The main goal is to see if the drug changes a blood test linked to …

This study aims to make laser therapy for port-wine birthmarks more effective in children, so fewer treatments are needed and less general anesthesia is required. Researchers will test different laser methods on 200 children aged 2 months to 18 years. The goal is to lighten or cl…

This study compares two methods of giving surfactant, a medicine that helps premature babies breathe. One method uses a thin tube, the other uses a small airway device. The goal is to see which method causes fewer breathing problems and complications. The study will include 40 in…

This study looks at three different forms of potassium citrate—a common medication to prevent kidney stones—to see which one works best and is easiest to take. Twenty adults with kidney stones will try each form for one week, then provide urine samples and fill out surveys. The g…

This study helps doctors get better at talking with teenagers and their parents about birth control. Doctors will practice these conversations with computer-generated avatars that act like real teens and parents. The goal is to see if this training boosts doctors' confidence and …

This study looks at how heart rate variability (a measure of nervous system health) relates to emotional control and parent-teen relationships in 74 adolescents with major depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to u…

This early study tests a non-invasive device that delivers low-intensity electric fields (TTFields) to people with stage I to IIIA non-small cell lung cancer before they have surgery. The main goal is to see how these fields affect certain genes linked to DNA repair. About 18 adu…

This study looks at how the drug Cobenfy KarXT changes brain activity related to memory. About 50 adults with epilepsy who are already having brain surgery for seizure monitoring will take either the drug or a placebo. Researchers will measure brain signals to see if the drug boo…

This study looks at whether sending automated MyChart messages and texts to cancer patients after they leave the hospital can steer them toward urgent oncology care instead of the emergency room. About 200 adults with active cancer who recently had chemotherapy and an ER visit wi…