University Of Texas Southwestern Medical Center

This early-stage study tests whether the investigational drug BMS-986353 is safe in adults with a specific type of neuromyelitis optica (NMOSD). Participants, who are already stable on standard treatments, will receive the study drug and continue their current therapy. The study …

This study tests whether a mobile app (DynamiCare) combined with patient navigation can help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine, and start or restart HIV prevention (PrEP) or treatment (ART). The pilot phase…

This study tests whether giving two drugs, ateganosine and cadonilimab, before surgery is safe and effective for people with liver cancer that can be removed. About 60 participants will receive the drugs before their planned operation. The main goal is to see if the treatment del…

This study tests whether adding deucravacitinib to current TNF inhibitor treatment helps adults with psoriatic arthritis who still have symptoms. About 128 participants will take the combination for 24 weeks to see if it improves skin and joint symptoms. The goal is better diseas…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This study tests whether a low dose of the drug erlotinib can prevent liver cancer in people with advanced liver scarring (fibrosis or cirrhosis). About 60 adults at high risk will receive either erlotinib or a placebo for a set time. Researchers will check if the drug changes a …

This study tests whether a powder containing potassium, magnesium, and citrate can help prevent or treat high blood pressure in African Americans. About 45 participants with pre- or stage 1 hypertension will take the supplement daily. The goal is to see if it lowers blood pressur…

This study tests two types of brain stimulation for people with depression that hasn't improved with medication. 247 adults will receive either a precise, guided form of stimulation, a standard form, or a fake (sham) treatment. The goal is to see which approach works best to ease…

This study tests whether people hospitalized for acute heart failure can safely go home early and continue treatment with a portable, under-the-skin diuretic instead of staying in the hospital for IV diuretics. About 250 adults will be randomly assigned to either early discharge …

This study tests whether a device called Lymphatic Enhancement Technology (LET) can reduce pain and improve quality of life in women with fibromyalgia. Forty participants will receive either active or sham LET treatments once a week for four weeks. Researchers will measure change…

This study compares two methods of giving surfactant, a medicine that helps premature babies breathe. One method uses a thin tube, the other uses a small airway device. The goal is to see which method causes fewer breathing problems and complications in infants born at 29 weeks o…

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study looks at two methods for giving a lung-helping medicine called surfactant to very premature babies (born at 22 to 28 weeks). One method uses a video camera to guide the procedure, the other uses direct sight. The goal is to see which method works better on the first tr…

This study looks at how the drug Cobenfy KarXT changes brain activity related to memory. About 50 adults with epilepsy who are already having brain surgery for seizure monitoring will take either the drug or a placebo and perform memory tasks. Researchers will compare brain recor…

This study looks at whether a non-invasive headband can accurately monitor brain blood flow in patients with a type of stroke called aneurysmal subarachnoid hemorrhage. Researchers will compare the headband's readings to standard invasive measurements. They will also test if nerv…

This study looks at whether wearing compression garments (like tight leggings) can help people with Fontan circulation pump more blood during exercise. Twenty adults with this heart condition will do exercise tests in an MRI and on a bike, with and without the garments. A few wil…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study looks at whether sending automated messages to cancer patients after they leave the hospital can help them use the right care—like an urgent care clinic—instead of going back to the emergency room. About 200 adults with active cancer who recently had an ER visit will t…

This early study tests whether applying low-intensity electric fields (TTFields) to the chest before lung cancer surgery is safe and affects cancer-related genes. About 18 adults with stage I-IIIA non-small cell lung cancer will wear a non-invasive device for a short time before …

This early-phase trial will test how Acetadote, a drug that affects cell damage, changes metabolism in people with newly diagnosed glioblastoma. Ten participants will receive Acetadote before surgery, and researchers will use MRI scans and tumor tissue analysis to measure metabol…

This study looks at how data from an Operating Room Black Box can be used to create virtual training that helps surgical teams work better and safer. About 30 experienced operating room staff will test the simulator. The goal is to improve teamwork and safety checklists during re…

This study looks at whether showing real-time visual feedback to emergency medical workers helps them deliver the right amount of air when giving rescue breaths during CPR. About 80 trained EMS responders will practice on a mannequin with and without feedback, using two different…

This study helps doctors get better at talking to teenagers and their parents about birth control. Doctors will practice conversations with computer-generated teens and parents that look and act like real people. The goal is to see if this training makes doctors more confident an…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study compares several over-the-counter and prescription alkalinizing agents to a standard slow-release potassium citrate in people with and without a history of kidney stones. Researchers will measure how each agent changes urine chemistry (volume, pH, and key stone-forming…

This study tests whether an automatic pop-up alert in electronic medical records helps primary care doctors screen patients for HIV, hepatitis B, and hepatitis C all at once. About 50 doctors will participate, and their encounters will be randomly assigned to either see the alert…

This study looks at three different forms of potassium citrate (a medication that helps prevent kidney stones) to see which one works best and is easiest for patients to take. About 20 adults who have had kidney stones before will try each form for one week, then provide urine sa…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…