University Of Texas Southwestern Medical Center

This study looked at whether changing the HIV medication of 26 adults with well-controlled HIV could lower their risk of heart disease. Participants switched from their current integrase inhibitor-based regimen to doravirine, while staying on the same backbone drugs. Researchers …

This study tested whether a blood test (AlloSure) can identify kidney transplant patients who can safely switch from several anti-rejection drugs to just one, Belatacept. 25 adults with stable kidney function were enrolled. The goal was to see if the test could predict who would …

This study tested whether a natural steroid called pregnenolone could help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for a set period. Researchers measured changes in mood, anxiety, thinking, and quality of…

This study tested whether using the UroLift system before targeted radiation is safe for men with both prostate cancer and an enlarged prostate (BPH). Fifteen men participated, and researchers monitored side effects within 90 days of treatment. The goal was to see if this combina…

This study looked at whether a higher daily dose of vitamin D (4000 IU) helps adults recovering from major burns feel better physically and mentally compared to the standard dose (400 IU). 48 adults with vitamin D deficiency and serious burns took part. The goal was to see if the…

This study tested a 10-session therapy program delivered over the phone or video to help adults with depression increase their physical activity. The goal was to see if the program was practical, well-liked, and could reduce depressive symptoms. Sixty-five adults with moderate-to…

This study tested whether ketamine, a fast-acting medication, can reduce suicidal thoughts and behaviors in teenagers more quickly than standard treatments. Fifty adolescents aged 13-18 who had recently attempted suicide or had serious suicidal thoughts received either ketamine o…

This study created a registry of 149 cancer patients who received a precise type of radiation called SBRT. The goal was to track how doctors use this treatment in different situations, such as for cancer that has spread, to shrink tumors before chemotherapy, or for repeat radiati…

This study looked at how a 3-day course of hydrocortisone (a corticosteroid) affects memory and the hippocampus, a brain region key for learning. Researchers used advanced MRI scans and memory tests in 66 healthy adults and people with depression. The goal was to understand which…

This study looked at how natural changes in sex hormones (like estrogen and progesterone) during the menstrual cycle affect muscle reflexes and brain signals in healthy women. Researchers also compared women using birth control pills to those not using them, and included men for …

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable. The goal was to see which one works better and whether either affects kidney function after surgery. Results help doctors …