University Of Texas Southwestern Medical Center

This study looked at whether regularly warming the lower legs in warm water (about 107°F) could help lower blood pressure in women aged 60-85 with high blood pressure. Participants did this 4 times a week for 8 weeks, while also taking a standard blood pressure pill. The goal was…

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tested whether Tenapanor, a drug approved for kidney disease, can reduce oxalate absorption from food and lower the risk of kidney stones. Eighteen healthy adults without a history of stones took the drug or a placebo, and their urine oxalate levels were compared. The …

This study tested a new program called Walk Together, designed to help African American patients and their family members work as a team to manage high blood pressure. The program was adapted from a proven approach and tested in a primary care setting with 62 participants. The ma…

This study tested a new treatment called Magnetic Seizure Therapy (MST) for people with severe depression that hasn't improved with medication. MST uses magnets to trigger a small, controlled seizure in the brain, similar to electroconvulsive therapy (ECT) but potentially with fe…

This study looked at whether giving heart failure patients healthy food—either medically tailored meals or fresh produce boxes—for 90 days after a hospital stay could reduce emergency visits and readmissions. It also tested if providing food only when patients attended follow-up …

This study tested whether adding an immunotherapy drug called APX005M to standard treatment helps people with advanced rectal cancer achieve a complete response (no cancer left after treatment). 58 adults with stage II or III rectal cancer at high risk took part. The goal was to …

This study tested a gentler way to give lung medicine (surfactant) to extremely premature babies (22-25 weeks) right in the delivery room. The goal was to see if this method could reduce the need for breathing tubes and mechanical ventilation in the first 72 hours of life. Sixty …

This early-phase study tested whether switching HIV medications to doravirine (with emtricitabine and tenofovir alafenamide) could improve cholesterol and reduce early signs of heart disease. 26 adults with well-controlled HIV and high cholesterol took part. Researchers measured …

This study tested whether giving focused radiation to leftover cancer spots after CAR-T cell therapy could help people with hard-to-treat non-Hodgkin lymphoma. Fourteen adults who still had signs of disease 30 days after CAR-T received radiation. The goal was to see if this appro…

This study tested a shorter, 3-week radiation treatment for people with HPV-related throat cancer. The goal was to see if a lower total dose given over fewer days is safe and tolerable. 24 patients participated, and the researchers monitored side effects to find the best dose.

This study tested whether a single daily pill containing three heart failure medications could help people with reduced heart function. It involved 212 adults from low-income and racially diverse backgrounds. The goal was to see if this simple approach could improve heart health …

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This study tested whether a single daily pill containing a statin, aspirin, and a blood thinner could help heart attack patients stick to their medications after getting a stent. The study involved 140 adults who had a heart attack and received a drug-coated stent. The goal was t…

This study tested whether taking probiotic capsules (Lactobacillus GG and Bifidobacteria) for 24 weeks could prevent people from being re-hospitalized for mania after a recent manic episode. 67 adults who were hospitalized for mania took either the probiotic or a placebo. The mai…

This study looked at whether a blood test called AlloSure can identify kidney transplant patients who can safely switch from several anti-rejection drugs to just one, belatacept. 25 adult kidney transplant recipients with stable kidney function were enrolled. The goal was to see …

This study tested whether real-time remote blood sugar monitoring and secure texting could help teens (ages 13-18) with poorly controlled type 1 diabetes improve their blood sugar levels. Twenty teens wore a continuous glucose monitor that shared their readings with the study tea…

This study tested whether a combination of two long-acting medications, naltrexone and buprenorphine, can help people reduce or stop using cocaine. Over 400 adults who wanted to cut down on cocaine use received either the drug combo or placebo injections for 8 weeks. The main goa…

This study tested whether the diabetes drug pioglitazone, weight loss, or both can raise urine pH in overweight adults with uric acid kidney stones. Low urine pH is a key cause of these stones. 29 participants were assigned to pioglitazone, weight loss, both, or placebo for 24 we…

This study looked at 205 pairs of caregivers with major depression and their children (ages 7-17) with asthma. Researchers tracked whether improving the caregiver's depression symptoms led to better asthma control, fewer flare-ups, and improved quality of life for the child over …

This study looked at whether giving two medicines (fentanyl and atropine) before a less invasive breathing treatment helps preterm babies born at 29 weeks or later. The goal was to see if these medicines reduce episodes of low heart rate and low oxygen during the procedure. 58 ba…

This small pilot study tested whether a gentle, non-invasive brain stimulation technique called HD-tDCS could improve memory and word recall in 27 older adults with mild cognitive impairment (MCI). Participants received 10 sessions targeting a brain region linked to memory. The g…

This study looked at whether adding an extra nerve block in the armpit to the standard shoulder block can better control pain after shoulder replacement surgery. 12 adults having shoulder replacement were enrolled. The goal was to see if the extra block reduces time in recovery, …

This study tested a special laser (1927nm) to reduce dark spots on the face in 15 adults with Fitzpatrick Skin Types V and VI (darker skin). The goal was to see if the laser works and to find the best skin care routine before and after treatment to avoid side effects like scarrin…

This small pilot study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help people with persistent symptoms after a mild concussion. Twelve adults who had symptoms for 3 to 12 months after their injury received either real or fake (…

This study tested a combination of three light treatments (broadband light, fractionated 1927, and dual wavelength 2940/1470) to improve skin pigmentation, texture, and sun damage. Fifteen healthy adults aged 20-75 received up to two treatments. Researchers used a special camera …

This study looked at whether a higher daily dose of vitamin D (4000 IU) is better than the standard dose (400 IU) for adults who had a major burn injury and are vitamin D deficient. 48 people took part, and researchers measured changes in their physical and mental health, as well…

This study tested whether it is safe to place a UroLift implant (a device that opens the urethra) before giving precise, high-dose radiation to men with both prostate cancer and an enlarged prostate (BPH). Fifteen men took part. The main goal was to see if the combination caused …

This study tested a system called PROMISE that uses movies to help children aged 3 to 11 stay still during radiation therapy, reducing the need for general anesthesia. The goal was to lower the number of children ages 3-7 needing anesthesia from 70% to 30%. The approach aims to m…

This study tested whether a natural brain chemical called pregnenolone can help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for a set time. Researchers measured changes in mood, anxiety, thinking, and quality…

This study tested a new type of radiation therapy that adjusts the treatment beam each day to match the patient's current anatomy. The goal was to see if this daily adaptive approach could reduce long-term dry mouth (xerostomia) compared to standard radiation in 50 people with he…

This study tested a non-invasive brain stimulation technique called HD-tDCS in 26 adults aged 50+ with mild memory problems and a history of traumatic brain injury. Participants received 10 sessions targeting a brain region linked to memory. The goal was to see if this could impr…

This study tested whether ketamine, a fast-acting medication, can reduce suicidal thoughts and behaviors in teenagers more quickly than standard treatments. Fifty adolescents aged 13 to 18 who had recently attempted suicide or had serious suicidal thoughts received either ketamin…

This pilot study tested a 10-session behavioral activation program delivered via teletherapy to help adults with moderate-to-severe depression increase physical activity and reduce depressive symptoms. 65 participants were enrolled, and the study focused on whether the program wa…

This completed study involved 65 African American adults who use cocaine or other illicit substances and want to cut down or stop. Researchers gathered their feedback to create a manual called I-DREM, designed to improve how clinical trials recruit and retain Black participants. …

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and the brain's hippocampus in 66 healthy adults and people with depression. Participants took either the steroid or a placebo for three days and underwent memory tests and high-resolution …

This study explored whether inflammation or immune system problems play a role in teen suicide. Researchers took blood samples and surveyed 225 teens (ages 12-18) who had recent suicidal behavior, were at risk for depression, or were healthy. No treatment was given—the goal was t…

This study gave postmenopausal women with a common type of breast cancer a short course of letrozole before their scheduled surgery. The goal was not to treat the cancer, but to measure how much the tumor's growth slowed down, helping doctors tell which cancers are strongly drive…

This study looked at how radiofrequency ablation (using heat) affects adenomyosis tissue in 15 women who were already scheduled for a hysterectomy. The goal was to see how well the treatment destroys the abnormal tissue by examining it under a microscope after surgery. The study …

This study looked at how heat waves impact the heart and body temperature in healthy older adults (65+) compared to younger people. Researchers measured core body temperature and heart function during simulated heat wave conditions. The goal was to understand the risks so we can …

This study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs, like whole-body or single-leg training, could improve their fitness. The study involved 93 older …

This pilot study tested whether a non-invasive eye scan (OCTA) can spot changes in the eye's blood vessels that might relate to brain diseases like stroke or brain bleeding. Researchers compared scans from 7 people with neurological conditions and healthy volunteers. The goal was…

This study looked at how blood pressure medications affect brain blood flow and the nervous system in older adults with high blood pressure. Researchers gave 27 participants either a drug or a placebo for 1-2 weeks and measured brain blood flow, cognitive function, and nerve acti…

This study looked at two new methods to measure how well the brain controls its blood flow after injury in children. Researchers monitored 29 children with brain injuries to compare these methods. The goal was to find a better way to check brain health and guide treatment.

This study tested a virtual reality simulator designed to train surgeons in repairing a hiatal hernia. Eight general surgery residents participated, with some using the simulator and others not. Researchers measured how quickly and accurately they performed the procedure, both on…

This study looked at 86 people with very high or very low cholesterol efflux—how well the body removes cholesterol from cells. Researchers analyzed their genes, proteins, and fats to find clues that could lead to new heart disease treatments. The goal was to gather knowledge, not…

This study looked at whether a special approach to offering genetic testing could help more family members of people with hereditary cancer genes get tested. About 108 adults with a cancer gene variant and their relatives took part. The goal was to see if a choice-based method wo…

This study tested a special vest designed to protect central venous catheters (CVCs) in children aged 0-12. Researchers wanted to see if the vest was practical and how satisfied parents and nurses were with it. 30 children participated, and parents and nurses provided feedback th…

This study brought together 50 international experts to agree on what training doctors need to safely manage breathing tubes in critically ill patients. Using a structured survey method, the panel voted on key training requirements. The goal is to create a standard curriculum to …

This study enrolled 17 adults with liver cancer who were scheduled for standard treatments like TACE, ablation, or Y90. Researchers took blood samples before and after treatment to search for proteins (biomarkers) that might predict how well a patient responds. No new treatment w…

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable during the operation. The main goal was to see how much of each drug was needed. Researchers also checked if either drug le…

This study created a registry to track how cancer patients respond to a precise type of radiation called SBRT. It included 149 adults with solid tumors who received SBRT for limited spread, before or after chemotherapy, or for repeat treatment. The goal was to better understand t…

This study looked at how natural changes in sex hormones (like estrogen and progesterone) affect muscle reflexes and brain signals in healthy women and men. Researchers measured reflexes, spinal cord activity, and brain responses in 102 participants during different phases of the…

This study aimed to learn how blood disorders affect the daily lives and emotions of children and teens aged 12 to 21. Researchers interviewed 15 young people with bleeding or clotting disorders to hear their perspectives on quality of life, confidence in managing their condition…