HIV drug switch may protect hearts from hidden damage

NCT ID NCT04820933

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 29 times

Summary

This study looked at whether changing the HIV medication of 26 adults with well-controlled HIV could lower their risk of heart disease. Participants switched from their current integrase inhibitor-based regimen to doravirine, while staying on the same backbone drugs. Researchers measured changes in cholesterol and other early signs of artery hardening. The goal was to see if doravirine is a more heart-friendly option for long-term HIV management.

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Contacts and locations

Locations

  • University of Texas Southwestern

    Dallas, Texas, 75219, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75219, United States

Conditions

Explore the condition pages connected to this study.