Steroid study reveals brain changes in just 3 days

NCT ID NCT03896659

First seen Jan 11, 2026 · Last updated May 16, 2026 · Updated 16 times

Summary

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. 66 healthy adults and people with depression took either the drug or a placebo for 3 days. Researchers used memory tests and high-resolution MRI scans to see changes in the hippocampus, a key brain region for memory. The goal was to understand how these common drugs impact the brain, especially in people with depression.

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Contacts and locations

Locations

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

Conditions

Explore the condition pages connected to this study.