Steroid study reveals brain changes in just 3 days

NCT ID NCT03896659

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. Researchers gave 66 healthy adults and people with depression either the steroid or a placebo for three days, then used memory tests and advanced MRI scans to see changes. The goal was to understand which parts of the hippocampus are most sensitive to steroids and whether people with depression respond differently.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

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