Weight loss and drug combo may dissolve kidney stone risk
NCT ID NCT04370093
First seen Sep 30, 2025 · Last updated May 29, 2026 · Updated 30 times
Summary
This study tested whether the diabetes drug pioglitazone, weight loss, or both can raise urine pH in overweight adults with uric acid kidney stones. Low urine pH is a key cause of these stones. 29 participants were assigned to pioglitazone, weight loss, both, or placebo for 24 weeks while on a fixed diet. The main goal was to see if urine pH increased, which could help prevent future stones.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390-9107, United States
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