One pill to rule them all? polypill aims to boost heart drug adherence
NCT ID NCT05514938
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pills. The goal was to see if the polypill helped patients stick to their medications and improved cholesterol and blood clotting levels at one month.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Polypill (rosuvastatin, aspirin, and either clopidogrel or prasugrel)
What this could lead to
If it works, this could simplify post-heart-attack care by combining multiple daily pills into one, making it easier for patients to stick with their medications and potentially reducing future heart problems.
What could go wrong
This is a small, early-phase study (140 participants) focused on short-term lab results, not long-term outcomes like survival. The polypill may not work for everyone, and side effects from the combined drugs are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UT Southwestern Medical Center
Dallas, Texas, 75235, United States