One pill to rule them all? polypill aims to boost heart drug adherence

NCT ID NCT05514938

Completed Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pills. The goal was to see if the polypill helped patients stick to their medications and improved cholesterol and blood clotting levels at one month.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Polypill (rosuvastatin, aspirin, and either clopidogrel or prasugrel)
What this could lead to: If it works, this could simplify post-heart-attack care by combining multiple daily pills into one, making it easier for patients to stick with their medications and potentially reducing future heart problems.
What could go wrong: This is a small, early-phase study (140 participants) focused on short-term lab results, not long-term outcomes like survival. The polypill may not work for everyone, and side effects from the combined drugs are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome coronary artery disorder hyperlipidemia Lipid Metabolism Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROME CORONARY ARTERY DISEASE LIPID DISORDER

Contacts and locations

Locations

UT Southwestern Medical Center

Dallas, Texas, 75235, United States

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