ACUTE CORONARY SYNDROME

This pilot study tests whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific genetic change (TET2-CHIP). Participants take colchicine or standard care for 12 months. The goal is to see if this genetic marker can guide personalized …

This study tests whether a digital support program (called DEEPER) helps heart patients maintain their health after completing cardiac rehab. About 306 adults with heart disease or heart failure will be split into two groups: one gets standard follow-up care, the other gets stand…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study compares two medicated stents (tiny mesh tubes) used to open blocked heart arteries in people having a heart attack or unstable angina. About 2,100 participants will receive either a sirolimus-eluting stent (ihtDEStiny) or an everolimus-eluting stent (Xience). Research…

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

This phase 3 trial tests whether the drug dalcetrapib can reduce the risk of major heart problems like heart attacks in people who have a specific genetic makeup (AA genotype) and have recently had a heart-related event. About 2,000 participants will receive either dalcetrapib or…

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study tests whether a two-drug combination of dabigatran and ticagrelor can lower bleeding risk compared to the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in people with atrial fibrillation who have had a heart stent after a heart attack. About 1,200 …

This study tests whether adding evolocumab, a cholesterol-lowering drug, to standard care can slow or stop plaque buildup in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack or unstable angina will receive either evolocumab plus sta…

This Phase 3 trial tests whether adding doxycycline to standard tuberculosis treatment can reduce permanent lung damage and lower the risk of heart problems. Researchers will give 150 adults either doxycycline or a placebo for 8 weeks alongside their TB medication. The main goal …

This study compares a new artificial intelligence (AI) method that uses X-ray images to guide heart artery stenting against the standard invasive method. About 2100 adults with narrowed heart arteries will be randomly assigned to one of the two approaches. The goal is to see if t…

This study looks at two types of stents (small mesh tubes) placed in heart arteries to keep them open. It focuses on patients with acute coronary syndrome who also have a high risk of bleeding. The goal is to see how well the blood vessel heals around the stent one month after th…

This study tests a new device that freezes dangerous plaque in heart arteries to see if it can reduce blockages and prevent future heart problems. About 30 people with stable angina or recent heart events will receive the freezing treatment during a planned procedure. Researchers…

This study compares two blood thinner combinations in adults over 65 who have had a heart attack or unstable angina and received a stent. One group gets indobufen plus ticagrelor, the other gets aspirin plus ticagrelor. The goal is to see which combo better prevents heart-related…

This study tests whether a reduced dose of the blood thinner prasugrel (5 mg), taken alone without aspirin, is safe and effective for patients who have had a stent placed for heart disease. Researchers will compare this approach to standard dual antiplatelet therapy (aspirin plus…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent heart attacks and strokes in people at risk. About 130 adults aged 40-75 who are in the ER for possible heart issues will receive guideline-based care. The goal is to low…

This study compares two treatments for people with severe blockages in multiple heart arteries who are having a heart attack without ST elevation. One treatment is stenting (a tube to open arteries), the other is bypass surgery (rerouting blood flow). The goal is to see if stenti…

This study tests if taking colchicine (an anti-inflammatory drug) along with a single blood thinner (ticagrelor) right after a heart attack stent is safe and works well. About 490 adults who had a heart attack and received a specific type of stent will participate. The goal is to…

This study looks at whether taking just one blood thinner (single antiplatelet therapy) is safer and as effective as taking two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a balloon procedure to open blocked heart arteries. About 576…

This study tests whether combining three standard heart medications (aspirin, a blood thinner, and a statin) into a single daily pill helps people who've had a heart attack take their medicine more consistently. About 1,000 adults who recently had a heart attack and a stent place…

This study tests whether a new pressure microcatheter works as well as the standard pressure wire for guiding stent placement in people with coronary artery disease. About 2,500 participants will be randomly assigned to one of the two devices during their procedure. The main goal…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study looks at whether taking two blood thinners (ticagrelor plus aspirin) is better than aspirin alone for keeping bypass grafts open in people who had heart surgery after a heart attack. About 360 participants will be followed for 1 to 3 years, and their grafts will be che…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This study follows 500 people who already have or will get the AngelMed Guardian® implant, a device that monitors heart signals and alerts patients to possible heart attacks. Participants are high-risk heart patients with conditions like diabetes or prior heart attacks. The goal …

This study looks at 2,600 heart attack patients who had a stent placed and also have an H. pylori infection. Half will get a 2-week course of vonoprazan plus amoxicillin to treat the infection, while the other half gets a standard 6-month acid blocker (pantoprazole). The goal is …

This study tests whether a risk score (OPT-CAD) can safely guide how long heart attack patients need to take two blood thinners after getting a stent. About 3,490 participants will either follow standard 12-month dual therapy or have their therapy reduced to one blood thinner ear…

This study is testing whether artificial intelligence (AI) can predict or rule out a heart attack using data from standard blood tests. Researchers will analyze white blood cell properties from over 3,000 adults who come to the hospital with chest pain. The goal is to see if AI c…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This study tests a new, noninvasive device that uses ultra-sensitive magnetocardiography to detect heart attacks. Researchers will enroll nearly 4,000 healthy volunteers and chest pain patients to see if this magnetic scan can identify heart damage more accurately than current me…

This study tests a 12-week program that combines positive psychology and motivational interviewing to help people who have had a heart attack become more physically active. The program is delivered remotely via phone and text messages. Researchers will compare activity levels and…

This study tests whether an online cognitive behavioral therapy (CBT) program can reduce heart-related anxiety in people who have had a heart attack or unstable angina. 176 participants will be randomly assigned to either the CBT program or a digital lifestyle advice group. The g…

This study investigates whether blood sugar patterns, measured continuously with a wearable sensor, can predict serious heart problems in the year following a heart attack. Researchers will enroll 850 people hospitalized with acute coronary syndrome and track their glucose levels…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study looks at tiny particles called exosomes in the blood of 300 people who experienced sudden cardiac death after a heart attack. Researchers want to see if certain molecules in these particles can help predict who is at highest risk. The goal is to improve early warning a…

This study is creating a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular data to understand how symptoms and disease patterns may vary among women. The goal is to identify subtypes of heart disease…

This study follows 20,000 heart attack patients who are discharged early from the hospital after a minimally invasive procedure. Researchers want to see how well medications are adjusted, track major heart events, and measure quality of life over one year. No new treatment is giv…

This study tests a dynamic coronary roadmap system that helps doctors guide a pressure wire into narrowed heart arteries. 226 patients with ischemic heart disease will be randomly assigned to have the procedure with or without the roadmap. The main goal is to see if the roadmap r…

This study looks at 200 people having a heart attack to see if a special camera (OCT) inside the arteries correctly identifies the type of plaque that caused the attack. Researchers will compare the camera images with the actual plaque material removed during a standard procedure…

This study is collecting information from 11,000 people who have had a heart attack or heart muscle injury. Researchers want to learn more about these conditions to improve future treatment. The study does not test a new drug or procedure, but instead gathers data to better under…

This study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic fields to detect blocked arteries (ischemia). Researchers will enroll 150 adults scheduled for heart catheterization to see if the device can accurately predict heart attack status. T…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…