ACUTE CORONARY SYNDROME

This study tests if starting inclisiran early in the hospital can lower bad cholesterol more than a placebo in people who just had a heart attack. About 300 adults will receive either inclisiran or a placebo alongside standard care. The goal is to see if this approach helps contr…

This study looks at whether adding low-dose colchicine to a single blood thinner (ticagrelor) after heart stent placement can reduce heart-related complications in people with acute coronary syndrome. About 490 adults will take colchicine for one month and then stop if their infl…

This study tests whether a simple risk score (OPT-CAD) can guide doctors on when to safely switch heart attack patients from two blood thinners to just one. About 3,500 participants will be assigned to stop one blood thinner at either 1 or 3 months based on their risk level. The …

This study involves 500 people who have already received the AngelMed Guardian device, an implant that monitors the heart for signs of a heart attack. The goal is to see how well the device works in everyday use to detect acute coronary syndrome (like heart attacks) and reduce fa…

This study compares an artificial intelligence (AI) method to the standard invasive method for guiding stenting in people with narrowed heart arteries. About 2100 adults with coronary artery disease will be randomly assigned to one of the two approaches. The goal is to see if the…

This study compares a new stomach acid reducer (tegoprazan) with a standard one (rabeprazole) in about 3,320 heart patients who take blood thinners and are at high risk for stomach bleeding or ulcers. The goal is to see if the new drug works just as well at preventing serious sto…

This study tests if a new pressure microcatheter is as good as the standard pressure wire for deciding when and how to place stents in heart arteries. About 2500 adults with stable heart disease or recent non-emergency heart attack will be randomly assigned to one device or the o…

This study compares two treatments for people with multiple blocked heart arteries who have had a recent heart attack or unstable angina. One treatment is stenting (a less invasive procedure to open blockages), and the other is bypass surgery (a more invasive surgery to reroute b…

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can reduce lung damage and improve heart health. About 150 adults with active TB and lung cavities will receive either doxycycline or a placebo for 8 weeks. Researchers will measure…

This study looks at 2,600 adults who have had a heart attack, received stents, and also have an H. pylori stomach infection. These patients take blood thinners that raise their risk of stomach bleeding. The trial compares a new drug (vonoprazan plus amoxicillin) against a standar…

This study tests a drug called dalcetrapib in 2,000 people who have a specific gene (AA genotype) and recently had a heart attack or related event. The goal is to see if the drug can lower the chance of another heart attack or stroke. Participants will take either the drug or a p…

This study looks at whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as using two (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 partici…

This study tests whether combining three standard heart attack medicines into one pill helps patients take them correctly and avoid future heart problems. About 1000 adults who recently had a heart attack will either get the single pill or their usual separate pills. The goal is …

This study looks at 360 people who had a heart attack and then bypass surgery. It compares taking just aspirin versus aspirin plus another blood thinner (ticagrelor) to see which better keeps the new bypass grafts open. Graft patency is checked with a special CT scan 12 to 36 mon…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time, compared to a permanent metal stent. The goal is to see if the dissolvable stent is safe and works as well for people with blocked heart arteries. About 1,859 adults with coronary arte…

This study aims to see if a new, noninvasive test called magnetocardiography (MCG) can accurately identify heart attacks. Researchers will enroll about 3,841 healthy volunteers and people with chest pain to compare MCG results with standard tests like EKG and blood tests. The goa…

This study tests whether a special dye (Florbetaben) used with a PET scan can detect inflamed plaque in the arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method is feasible for identifying dangerous plaque that migh…

This study tests if an online therapy program (CBT) can help people who had a heart attack feel less anxious about their heart and improve their quality of life. About 176 adults who had a heart attack at least 6 months ago and still have significant heart-related fear will take …

This study tests a 12-week remote program that combines positive psychology and motivational interviewing, plus text messages, to help 280 heart attack survivors who are not very active. The goal is to see if the program increases moderate to vigorous physical activity compared t…

This study is gathering information from 11,000 people who have had a heart attack or heart muscle injury. The goal is to learn more about these conditions and how they are treated. No new drugs or procedures are being tested. Participants will have their health tracked over time…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This research study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic field to see if it can help doctors detect when the heart muscle isn't getting enough blood (ischemia) or has been damaged by a heart attack. About 150 adults scheduled for a…

This study looks at how two different types of stents (small mesh tubes placed in heart arteries) heal one month after being implanted. It involves 60 people with acute coronary syndrome who also have a high risk of bleeding. Researchers will use a special imaging technique calle…

This study is building a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic and biological information to better understand how heart disease differs among women. The goal is to identify subtypes that could lead to more personal…

This study looks at tissue removed from the blocked arteries of 200 people having a heart attack. Researchers want to see if images taken during the procedure match what they find under a microscope. The goal is to improve how doctors identify the type of plaque causing the heart…