ACUTE CORONARY SYNDROME

This study tested whether a single daily pill containing a statin, aspirin, and a blood thinner could help underserved heart attack patients who received a stent stick to their medications. 140 adults took either the polypill or their usual separate medicines. The goal was to see…

This study looked at a new combination of two blood thinners (rivaroxaban and ticagrelor) for people with atrial fibrillation who had a heart stent placed. The goal was to see if this combo causes less bleeding than the standard three-drug therapy, while still preventing heart at…

This study looked at 190 adults who had a heart attack or unstable angina (acute coronary syndrome) to see if moderate-dose statins could lower LDL cholesterol as effectively as high-dose statins. After 3 months of treatment, researchers measured how many patients reached a 50% o…

This study tested a newer type of heart stent (Xience Sierra) in 1757 people with heart disease, including many with diabetes or prediabetes. The goal was to see if the stent is safe and works well in both general and high-risk patients. Researchers tracked heart-related events l…

This study tested whether the anti-inflammatory drug colchicine could reduce complications like irregular heartbeat, heart attack, and post-surgery inflammation in 100 patients undergoing coronary artery bypass grafting after a recent heart attack. Participants received colchicin…

This study looked at whether taking two blood thinners (clopidogrel and aspirin) for a longer time after getting a heart stent helps prevent future heart attacks, strokes, or death in people with multiple blocked heart arteries. About 8,250 adults aged 18-75 who already had a ste…

This study tested a new daily pill called milvexian in over 14,000 people who recently had a heart attack or unstable angina. The goal was to see if adding this blood thinner to standard care could lower the chance of another heart attack, stroke, or heart-related death. Particip…

This study tested a drug called evolocumab in 60 people who had a recent heart attack (a type called NSTEMI). The goal was to see if the drug could lower cholesterol and reduce inflammation in the heart and blood vessels. Participants received either evolocumab or a placebo, and …

This study looked at whether the drug vericiguat helps people who recently had a heart attack (acute coronary syndrome) and have a weak heart pump (ejection fraction below 45%). The main goal was to see if it lowers the chance of dying from heart problems or being hospitalized fo…

This study tested a new method called JINS for placing drug-coated stents in the heart arteries of 161 people with acute coronary syndrome. The goal was to see if this simpler approach could still achieve good stent placement while reducing unnecessary radiation and complications…

This study tested whether a hospital care pathway that includes the drug inclisiran can better lower LDL cholesterol in people who recently had a heart attack or unstable angina. About 400 participants with high cholesterol despite statin therapy were enrolled. The goal was to se…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic visits, is as effective as going to the clinic for rehab. 206 adults with heart conditions took part. The goal was to see if remote options could improve access and outcomes.

This study looked at over 3,400 people who had a heart attack or unstable angina and needed a stent to open blocked heart arteries. Researchers compared two types of stents (one with a permanent coating, one with a coating that dissolves) and two doses of the blood thinner prasug…

This study looked at how well the Orsiro stent, a small mesh tube that props open blocked heart arteries, works in everyday medical practice. Over 550 people with coronary artery disease received the stent. The main goal was to see if the stent performed as well in real life as i…

This study tested whether giving heart attack patients remote monitoring devices to use at home could reduce the need for hospital readmissions. 337 participants with high cardiovascular risk took part. The goal was to see if telemedicine could safely provide necessary care witho…

This study tested a computer program that helps doctors decide which cholesterol-lowering medicines to prescribe after a heart attack. Over 1,100 patients took part across multiple hospitals. The tool gave doctors personalized risk estimates and treatment suggestions based on gui…

This study tested whether sending educational text messages to people who had a heart attack could help them control risk factors like blood pressure and cholesterol, and prevent future heart problems. 370 patients participated and received text messages for one year. The goal wa…

This study looked at whether taking aspirin twice a day (morning and evening) works better than once a day to prevent another heart attack, stroke, or need for emergency heart procedures in people with diabetes who have had a recent heart attack or unstable angina. About 2,500 pa…

This study tested whether evolocumab, a drug that lowers bad cholesterol, can also reduce inflammation and heart damage after a heart attack. 100 adults who recently had a heart attack received either evolocumab or a placebo. The goal was to see if the drug could lower cholestero…

This study tested whether a decision rule, combining the Marburg Heart Score with a rapid troponin blood test, can help general practitioners safely rule out serious heart problems in people with new chest pain. Over 900 adults with chest pain took part. The goal was to see if th…

This study tested whether offering genetic testing for familial hypercholesterolemia (an inherited form of very high cholesterol) to people hospitalized for a heart attack could help doctors diagnose the condition earlier. Researchers enrolled 140 patients under age 60 who had a …

This study looked at 66 adults who came to the emergency room with chest pain but no clear signs of a major heart attack on their first ECG. Researchers used a special heart ultrasound technique (tissue Doppler imaging) to measure the S' wave, a marker of heart muscle movement. T…

This study aimed to create a personalized risk model for people who had a heart attack (acute coronary syndrome). Researchers looked at medical tests, genetics, and other factors in 1,655 patients to predict who might have further heart problems or die. The goal was to help docto…

This study looked at how well two types of heart stents (SYNERGY and a bioresorbable scaffold) heal inside arteries after a heart attack. 22 people who had a heart attack were randomly assigned to get one of the stents. Three months later, doctors used a special camera to see how…

This study followed over 1,000 people with acute coronary syndrome (a serious heart condition) who received the intravenous blood thinner cangrelor during a procedure to open blocked arteries. Researchers tracked how many patients had bleeding events within 30 days after switchin…

This small pilot study tested whether a heart rehab program that mixes telehealth, home exercises, and clinic visits is practical for people who survived a heart attack. Ten participants were enrolled to see if they would stick with the program. The study was cut short due to a c…

This study looked at how long people who had a heart attack should take two blood thinners (aspirin plus another drug) to prevent future heart problems. Taking them longer can lower the risk of clots but raises the chance of dangerous bleeding. The trial tracked over 5,000 patien…

This study looked at whether patients who were hospitalized for a heart attack, stroke, or other heart-related event were prescribed the recommended cholesterol-lowering medications when they left the hospital. Researchers observed 129 patients to see how well doctors followed of…

This study looked at how a traditional Chinese medicine called Xuesaitong soft capsule affects blood platelets in 60 adults who had a heart attack and a stent placed. Participants took the capsule for 4 weeks, and researchers analyzed their platelets using advanced lab tests to u…

This study tested how different doses of aspirin affect the body's immune response. Healthy volunteers took various aspirin doses for 10-14 days, then received a substance that temporarily mimics flu-like symptoms. Researchers measured immune markers in blood and urine to see if …

This study looked at whether using a portable blood test in the ambulance can help paramedics better assess the risk of a heart attack in people with chest pain. Researchers combined data from over 5,000 patients to see how accurate these tests are. The goal is to help decide who…

This study looked at how over 2,800 heart attack patients in Italy were treated with blood-thinning medications during their hospital stay. Researchers wanted to see which drug combinations and timing doctors actually use in real-world practice. The goal was to describe current t…

This study tested a new blood thinner called vicagrel against the standard drug clopidogrel in 18 healthy adults who have a specific gene that helps process these medicines. The goal was to see how the body absorbs and responds to each drug. Results will help doctors understand i…

This study looked at 1,000 people who had a heart attack to understand why some had no common risk factors like smoking, high blood pressure, or diabetes. Researchers compared those with and without these risk factors to find new clues in blood tests, imaging, and health history.…

This study looked at 2,000 adults with early heart disease to understand how inherited high cholesterol (familial dyslipidemia) contributes to heart attacks. Researchers reviewed medical records to find patterns in cholesterol levels. The goal was to improve screening and treatme…

This study looked at 88 heart attack patients to find out what makes them more likely to get kidney injury from the contrast dye used during procedures to open blocked arteries. Researchers checked blood and urine tests before and after the procedure. The goal is to help doctors …

This study combined data from over 1,700 people who had a heart attack or unstable chest pain to find out what makes plaque in heart arteries erode. Researchers looked at imaging and health records to identify patterns. The goal was to better understand the condition, not to test…

This study looked at how a marker of inflammation called C-reactive protein (CRP) changes in the blood of 35 people having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points up to 30 days after. The goal was to…