Could a lower aspirin dose calm the immune system without increasing bleeding?
NCT ID NCT03869268
First seen Jun 26, 2026 ยท Last updated Jun 26, 2026
Summary
This completed study looked at how different doses of aspirin, given with or without another drug called ticagrelor, affect the body's immune response. Healthy volunteers took the medications for 10-14 days, then received an injection that causes temporary flu-like symptoms to test their immune reaction. The goal was to see if a lower, twice-daily aspirin dose might reduce inflammation while potentially lowering bleeding risk, which could help improve heart attack treatment.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- Aspirin and ticagrelor
- What this could lead to
- If successful, this study could help doctors choose aspirin doses that reduce bleeding risk while still controlling inflammation after a heart attack.
- What could go wrong
- This is a small, early-phase study in healthy volunteers, not heart attack patients. The immune response to endotoxin may not reflect real-world outcomes, and results may not lead to changes in clinical practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, South Yorkshire, S5 7AU, United Kingdom
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Other studies related to the condition(s) this trial covers.
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