Could a lower aspirin dose calm the immune system without increasing bleeding?
NCT ID NCT03869268
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed study looked at how different doses of aspirin, given with or without another drug called ticagrelor, affect the body's immune response. Healthy volunteers took the medications for 10-14 days, then received an injection that causes temporary flu-like symptoms to test their immune reaction. The goal was to see if a lower, twice-daily aspirin dose might reduce inflammation while potentially lowering bleeding risk, which could help improve heart attack treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aspirin and ticagrelor
What this could lead to
If successful, this study could help doctors choose aspirin doses that reduce bleeding risk while still controlling inflammation after a heart attack.
What could go wrong
This is a small, early-phase study in healthy volunteers, not heart attack patients. The immune response to endotoxin may not reflect real-world outcomes, and results may not lead to changes in clinical practice.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, South Yorkshire, S5 7AU, United Kingdom