Sheffield Teaching Hospitals Nhs Foundation Trust

This study looks at whether advanced heart scans (echocardiogram and MRI) can improve diagnosis of heart failure with preserved ejection fraction (HFpEF), a condition where the heart is stiff but pumps normally. About 40 adults with symptoms like breathlessness but unclear standa…

This study tests whether a small, non-invasive device that stimulates a nerve in the ear (tVNS) is tolerable and practical for people recovering from a brain bleed (aneurysmal subarachnoid haemorrhage). About 30 participants will receive either the real device or a sham (dummy) d…

This study tests a safe, non-invasive ear stimulation device (tVNS) paired with computer-based speech therapy for people with chronic aphasia after stroke. 36 participants will use the device at home for 6 weeks. The goal is to see if this approach is feasible and helps improve w…

This study tests whether a probiotic drink called Symprove can relieve persistent gut symptoms like bloating and pain in adults with coeliac disease who are already on a strict gluten-free diet. About 24 participants will take the probiotic daily, and researchers will track sympt…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study is collecting information on the safety of a gel spacer (SpaceOAR) placed between the prostate and rectum during radiation therapy for prostate cancer. About 320 men in the UK and France who are already receiving this spacer as part of their care will be followed for u…

This study compares a pre-recorded dietitian-led webinar to traditional one-on-one appointments for adults newly diagnosed with coeliac disease. The goal is to see if the webinar is just as effective at teaching patients how to follow a gluten-free diet. Sixty participants will b…

This study tests new ways to measure lung function in 60 people with cystic fibrosis. Participants will breathe in a harmless gas (xenon) for a special MRI and do a simple breathing test. The goal is to get a clearer picture of how the lungs change over time, which could help imp…

This study tests a treatment called Remote Ischaemic Conditioning (RIC) for people who have broken a hip. RIC uses a blood pressure cuff on the arm or leg to briefly stop blood flow, which may trigger the body to reduce inflammation and improve healing. The study will include 12 …

This study looks at how sleep quality affects surgeons' ability to perform operations. Researchers will track sleep patterns and test surgical skills in 20 surgical trainees and consultants. The goal is to see if improving sleep can boost performance. This is a small early-stage …