Sheffield Teaching Hospitals Nhs Foundation Trust

This study tests whether implanted monitors can quickly show if a new PAH drug is working. About 40 adults with stable PAH will try two different approved drug plans while their heart and lung function are tracked. The goal is to see if this approach can help doctors choose the b…

This study tests whether a small, handheld device that gently stimulates a nerve in the ear (tVNS) is safe and practical for people recovering from a brain bleed (aneurysmal subarachnoid haemorrhage). About 30 participants will receive either the real stimulation or a dummy versi…

This study looks at whether advanced heart scans (echocardiogram and MRI) can help diagnose a type of heart failure called HFpEF, where the heart is stiff but pumps normally. Standard tests often miss it, leaving many without proper treatment. Researchers will study 40 adults wit…

This study tests whether a daily probiotic drink called Symprove can relieve ongoing gut symptoms like bloating, pain, and diarrhoea in adults with coeliac disease who already follow a strict gluten-free diet. About 24 participants will take the probiotic and report symptom chang…

This pilot study tests whether a non-invasive device that stimulates the vagus nerve through the ear can help people with chronic aphasia (trouble finding words) after a stroke. Thirty-six participants will use the device at home while doing computer-based speech therapy for six …

This study tests a treatment called Remote Ischaemic Conditioning (RIC) for people recovering from hip fracture surgery. RIC involves inflating a blood pressure cuff on the arm or leg for short periods to trigger the body's own protective responses. The trial will include 12 adul…

This study follows 320 men with prostate cancer who receive a hydrogel spacer (SpaceOAR) before radiotherapy. The spacer is placed between the prostate and rectum to protect healthy tissue. Researchers will collect data from medical records and patient questionnaires over three y…

This study tests advanced lung imaging (MRI with xenon gas) and breathing tests to better understand lung function in people with cystic fibrosis. 60 participants will be followed over time. The goal is to see if these new methods can detect changes more precisely than standard t…

This study compares a pre-recorded, on-demand webinar led by dietitians to traditional one-on-one appointments for people newly diagnosed with coeliac disease. Sixty adults will be split into two groups to see if the webinar is just as effective at teaching them how to follow a s…

This study is testing new heart MRI techniques to see how the heart adapts to stress, like exercise or fluid changes. Researchers will study 135 healthy volunteers and people with heart conditions. The goal is to improve understanding of heart function and develop better diagnost…

This study looks at how sleep quality affects surgeons' ability to perform surgery, both mentally and technically. Researchers will measure sleep patterns and give some surgeons a personalized sleep consultation, including advice on sleep habits and possibly therapy for insomnia.…