Sheffield Teaching Hospitals Nhs Foundation Trust

This study tested whether mepolizumab, an asthma drug, can reduce lung inflammation and flare-ups in people with COPD who have high levels of eosinophils (a sign of asthma-like inflammation). Thirty-one participants received mepolizumab every 4 weeks for a year and had MRI scans …

This study explores whether a powered exoskeleton—a wearable robot—can help people with moderate to severe walking problems due to multiple sclerosis (MS) exercise and walk better. Twenty-four participants will either use the exoskeleton or do standard exercises with a fitness in…

This study looked at 60 people with a common stomach condition called functional dyspepsia, which causes pain and fullness after meals. Participants were split into two groups: one followed standard advice (small meals, avoid fatty/spicy foods), and the other tried a low FODMAP d…

This pilot study tested whether lycopene, an antioxidant found in cooked tomatoes, can improve sperm quality in men with low total motile sperm count. 34 men took either lycopene capsules or placebo for 12 weeks. Researchers measured changes in sperm count, movement, shape, and D…

This study looked at how teriparatide (Forsteo), a daily injection, builds new bone in postmenopausal women with osteoporosis. Nineteen women took the drug for two years. The goal was not to test if it works, but to understand exactly how it changes bone density and turnover over…

This study followed 280 adults who came to the hospital with a painful hernia needing urgent care. Researchers wanted to see how doctors decide between surgery and non-surgical management, and how patients fared afterward. The goal is to gather real-world data to improve future t…

This study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…

This study looked at how being isolated during the COVID-19 pandemic affected the mental health of 232 people with inflammatory bowel disease (IBD). Researchers used questionnaires to measure depression, anxiety, and other psychological symptoms. The goal was to understand what f…

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This study tested whether a special MRI scan can measure how two common drugs, metformin and ciclosporin, affect the liver. Twelve healthy volunteers received the MRI dye gadoxetate before and after taking the drugs. The goal was to see if the scan could detect changes in liver f…

This study tested a new combination of very low-dose aspirin (20 mg twice daily) plus a blood thinner called rivaroxaban (2.5 mg twice daily) in 48 adults with chronic coronary syndromes. Researchers compared this new regimen to standard aspirin alone (75 mg once daily) and stand…

This completed study looked at how different doses of aspirin, given with or without another drug called ticagrelor, affect the body's immune response. Healthy volunteers took the medications for 10-14 days, then received an injection that causes temporary flu-like symptoms to te…