Liver MRI could spot dangerous drug interactions early
NCT ID NCT07541807
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether a special MRI scan can measure how two common drugs, metformin and ciclosporin, affect the liver. Twelve healthy volunteers received the MRI dye gadoxetate before and after taking the drugs. The goal was to see if the scan could detect changes in liver function, which could help identify risky drug interactions earlier in development.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gadoxetate (MRI dye), metformin, ciclosporin
What this could lead to
If successful, this could lead to a safer, non-invasive way to test how new drugs interact with the liver, reducing drug development failures.
What could go wrong
This is a very small, early-phase study in healthy volunteers, not patients. The MRI method may not prove reliable enough for widespread use.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LIVER DYSFUNCTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Royal Hallamshire Hospital
Sheffield, United Kingdom
-
University of Sheffield, POLARIS, 18 Claremont Crescent
Sheffield, S10 2RX, United Kingdom