Hidden gene changes may raise heart risk even after quitting smoking

NCT ID NCT04987268

Completed Knowledge-focused Sponsor: Shenyang Northern Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study looked at 1029 patients who had a heart attack or unstable angina and quit smoking. Researchers checked for certain gene mutations (called CHIP) in their blood. They wanted to see if these mutations are linked to a higher chance of future heart problems, like another heart attack or stroke, even after stopping smoking. The goal is to better understand why some former smokers still face heart risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help identify which former smokers with heart disease are at higher risk for future heart problems, leading to more personalized care.
What could go wrong: This is an observational study, not a treatment trial. It only looks for a link, so it cannot prove cause and effect. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute chest syndrome acute coronary syndrome clonal hematopoiesis of indeterminate potential Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACS CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL SMOKING CESSATION

Contacts and locations

Locations

General Hospital of Shenyang Military Region

Shenyang, Liaoning, 110016, China

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