Personalized nicotine patch dosing may boost quit rates
NCT ID NCT01622998
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether letting smokers adjust their own nicotine patch dose—based on their smoking history and withdrawal symptoms—helps them stay smoke-free longer than the standard fixed-dose patch. Adult smokers who smoke at least 10 cigarettes a day and are motivated to quit will be assigned to either the flexible dosing approach or usual care, with follow-up over a year. The main goal is to see if the flexible approach leads to higher rates of continuous abstinence, confirmed by breath tests, at 52 weeks after quitting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- transdermal nicotine patch (with optional dose adjustment) and nicotine inhaler as rescue
- What this could lead to
- If flexible, patient-directed nicotine patch dosing works better than the standard fixed dose, it could improve long-term quit rates for smokers.
- What could go wrong
- The trial is relatively small and relies on self-reported abstinence confirmed by breath tests; results may not apply to all smokers, and nicotine replacement can cause skin irritation or other side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
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