SMOKING CESSATION

This study compares three different quit-smoking programs for Black adults who smoke and want to quit. Participants will receive nicotine patches plus either standard quitline calls, more intensive counseling, or intensive counseling with financial incentives. The goal is to see …

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck, combined with a nicotine patch, can help people stop smoking. Researchers at Mayo Clinic will enroll 150 motivated smokers who smoke at least 10 cigarettes a day. Participants use the d…

This study is testing whether giving rural smokers a two-week supply of nicotine patches or lozenges can help them quit. Researchers are recruiting 272 adults from rural areas across the U.S. who smoke at least 5 cigarettes daily. The main goal is to see how many people stop usin…

This study tests a program to help adults in Lebanon quit smoking cigarettes or waterpipes. Participants receive phone counseling, nicotine patches, educational materials, and their doctors get training and electronic reminders. The goal is to see if this combination increases th…

This study tests two smoking cessation methods—varenicline pills and nicotine patches with gum—in 660 people with HIV in South Africa. Participants will receive one of these treatments for 12 weeks, along with counseling. The goal is to see which approach works best to help them …

This study tests a program called Smokefree Family Living (SFL) designed for Chinese American families. It combines smoking cessation education with tips to clean up third-hand smoke—the harmful residue that sticks to carpets, walls, and furniture. Researchers will enroll 760 par…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study is creating a mobile health (mHealth) system to help cancer patients stop smoking. Researchers will test if a smartphone app, combined with nicotine replacement therapy, is easy to use and acceptable to patients. The goal is to build a resource that can be used across …

This study tests a smoking cessation program for sexual and gender minority (SGM) adults in Oklahoma, Arkansas, and Texas. Participants get nicotine replacement therapy, a quit-smoking app, and join online volunteer activities to build social support. The goal is to help people q…

This study tests a telehealth program to help cancer survivors quit smoking, lose weight, and get more active. About 1500 participants will either get coaching sessions or just information. The goal is to see which approach works better for improving long-term health.

This study tests a program that combines brief advice, nicotine replacement therapy (like patches or gum), and text-message support to help smoking parents quit. The goal is to reduce children's exposure to secondhand smoke. About 1,200 smoking parents in Hong Kong who live with …

This pilot study is testing whether a simple blood test that measures how fast a person breaks down nicotine can help doctors choose the best medication to help Alaska Native and American Indian people quit smoking. The study will enroll 50 adults who smoke daily and are ready to…

This study tests a program called QuitAid, where pharmacists coach rural smokers on quitting. About 768 participants from Appalachia will get nicotine patches, and some will also get lozenges, text support, or phone counseling. The goal is to see which combination works best and …

This study tests whether a combination of varenicline (a pill) and nicotine patches can help people who both smoke cigarettes and use e-cigarettes quit smoking. About 500 participants will take the medications and be followed for 12 months to see if they stay smoke-free. The goal…

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This study tests Quitxt, a bilingual text and chat program designed to help young Latino adults (ages 18-29) quit smoking. About 1,200 participants will be randomly assigned to receive Quitxt or standard quit-smoking texts. Researchers will check if they've quit at 1, 3, and 6 mo…

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follic…

This early-stage study at Yale is testing whether a combination of two medications (naltrexone and bupropion) plus cognitive-behavioral therapy can help people who are considering bariatric surgery lose weight and stop smoking. Twenty participants will receive the treatment for f…

This study tests whether an electronic visit (e-visit) can help people in rural areas quit smoking. Participants are randomly assigned to receive the e-visit or standard care. The e-visit asks about smoking history and preferences, and may lead to a prescription for quit-smoking …

This study tests whether taking the quit-smoking drug bupropion for 6 months works better than the usual 7-week course for African American adults who smoke daily. Researchers will enroll 500 participants and check if more people stay smoke-free at 6 months with the longer treatm…

This study compares two smoking cessation programs for people undergoing lung cancer screening. About 1,188 participants will either receive phone counseling and nicotine replacement from a health system or be referred to a quitline. The goal is to see which approach leads to mor…

This study tests whether paramedics in rural areas can help smokers who aren't ready to quit by offering a text-based program called Take a Break, along with nicotine lozenges. The program includes a two-week smoke-free challenge and coaching calls. Researchers will track how man…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps more people stop smoking than standard advice. About 850 smokers and their doctors from primary care clinics will take part. The goal is to see if tailored …

This study tests whether offering financial rewards to Alaska Native adults and their family members helps them quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive program or standard support. Success is measured by a saliva test…

This study tests different ways to help smokers quit, including a smartphone app, written materials, and low-dose CT scans to screen for lung cancer. Researchers will enroll 1,200 smokers aged 50-74 and compare how many people successfully quit in each group. The goal is to see i…

This study tests a smartphone app (SFT 2.0) that uses motivational interviewing and a support person to help pregnant women stop smoking. About 790 pregnant smokers in Romania will use the app and receive counseling. The goal is to see if the app helps them quit and stay smoke-fr…

This study tests a personalized smoking cessation program for smokers admitted to the hospital with heart or lung disease. Participants receive tailored medication, counseling, and text message support to help them quit and stay smoke-free. The goal is to see if this approach lea…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests a smoking cessation program in the construction industry, where safety managers are trained to help workers quit smoking. About 608 construction workers will receive nicotine gum and access to a telephone quit-line. The goal is to find the most effective and cost…

This study is testing whether regular urine tests every 6 months can find bladder cancer earlier in people at high risk, such as smokers over 50 and those with long-term workplace chemical exposure. Researchers will enroll 1,000 participants and track how many cancers are detecte…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and visit a participating clinic will be assigned to either a program that uses personalized reminders and support (ELEVATE-S) or standard quit-focused care (ELEVATE…

This study tests whether combining text message support with financial incentives helps low-income pregnant women quit smoking more than text messages alone. Thirty pregnant women who smoke will be split into two groups to see which approach is more acceptable and effective. The …

This study tests a smartphone chatbot designed to help Black adults quit smoking. The chatbot sends alerts during times when a person is most likely to smoke and suggests ways to handle triggers. 120 participants will be randomly assigned to use the chatbot or not, and researcher…

This study tests whether nicotine pouches or mini lozenges can help people replace cigarettes. 300 adult smokers who aren't ready to quit will use one of these products or no product for a week, then try to stop smoking for 3 weeks. Researchers will track how many cigarettes they…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with overweight or obesity quit smoking. 300 smokers will receive either the drug or a placebo, plus nicotine patches, for 16 weeks. The goal is to see if the drug improves quit rates …

This study tests a 9-week mindfulness program (MBRP-SA) designed to help cancer survivors quit smoking and reduce heavy drinking. Six hundred participants in Florida will either get the mindfulness program plus nicotine patches or standard quitline support. The goal is to see if …

This study is testing a new smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. About 50 adults who have been diagnosed with cancer and smoke at least one cigarette a day will try the app. The goal is to see if the app is easy to use and if peopl…

This study partners with community organizations to adapt a smoking cessation program for adults who smoke and receive care at behavioral health clinics. Researchers will enroll 24 participants to test whether the program is feasible and acceptable. The goal is to learn how to be…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines proven methods to support smoking cessation and improve HIV/TB treatment results. Researchers will enroll 86 daily…

This study tests a program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. The program includes counseling sessions, family coaching, nicotine replacement therapy (like patches or gum), and information about lung cancer screenin…

This study tests an online questionnaire (e-visit) to help people quit smoking. About 672 adults who smoke daily will be randomly assigned to receive the e-visit or not. The e-visit asks about smoking history and preferences, and may lead to a prescription for quit-smoking medica…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study is for Veterans who smoke and want to quit. Each Veteran picks a friend or family member to support them during the quitting process. Researchers will track whether this support helps Veterans use proven treatments like medication or counseling. The goal is to find bet…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study tests whether adding music therapy to nicotine patches and gum can reduce tobacco cravings in student smokers aged 18-25. 120 participants will be randomly assigned to receive either nicotine replacement alone or nicotine replacement plus a digital music therapy tool. …

This study tests whether a personalized approach to smoking cessation helps cancer patients quit. Researchers will use patients' clinical, genetic, and biomarker information to create tailored treatment plans. The study involves 112 participants and compares this precision treatm…

This study tests a digital coaching program that uses a chatbot to help people quit smoking. The program aims to boost motivation, educate about quitting tools, and create a personalized quit plan. Researchers will enroll 440 adult smokers and check if they have quit after 6 mont…

This study tests a program called CONNECTing to LungCare that helps smokers have better conversations with their doctors about quitting smoking and getting screened for lung cancer. The program includes educational materials and a personalized summary to guide discussions. Resear…

This study looks at how romantic partners who both smoke can support each other when trying to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while attempting to quit, tracking their smoking, cravings, and stress. The goal is to understand which ty…

This study tests a program that combines help with quitting smoking and getting a lung cancer screening (a special CT scan) for African American smokers. The goal is to reduce the high rate of lung cancer in this group. About 250 people will take part, and researchers will track …

This study aims to understand what makes it easier or harder for African American smokers to use a smartphone app designed to help them quit. Researchers will first get feedback from a small group to improve the app, then test it with 30 people who want to quit. The app sends rem…

This study looks at whether a trauma-informed approach can improve smoking cessation support for pregnant women, especially those from racial and ethnic minority groups. Researchers will interview clinicians and pregnant women to understand their needs and experiences. The goal i…

This study tests whether the drug cytisinicline changes how the brain reacts to seeing smoking-related images in daily smokers who are not trying to quit. Sixty-four participants will receive either the drug or a placebo and undergo brain scans while watching videos of smoking an…

This study collects blood, airway, and urine samples from 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare samples to establish normal ranges and learn how genes change in lung disease. The goal is to better underst…

This pilot study at Memorial Sloan Kettering tests whether giving cancer patients an indoor air quality monitor helps them maintain a smoke-free home. Ten participants who smoke and are in a tobacco treatment program will use the monitor for about 60 days. Researchers will see if…