SMOKING CESSATION

This study tests a simple online questionnaire (e-visit) to help people stop smoking. About 672 adults who smoke daily will be randomly assigned to receive the e-visit or not. The e-visit asks about smoking history and preferences, and may offer a prescription for quit-smoking me…

This study tests a personalized smoking cessation program for 424 hospitalized smokers with heart or lung disease. A nurse-led team provides tailored medication, counseling, and text message support to help patients quit and stay smoke-free. The goal is to see if this approach le…

This study tests a smoking cessation program designed for LGBTQ+ adults who have high stress and little social support. Participants live in Oklahoma, Texas, or Arkansas and will receive nicotine replacement therapy plus empowerment-based coaching. The goal is to see if this appr…

This study tests a program called Smokefree Family Living (SFL) to help Chinese American smokers quit and reduce harmful smoke residue that lingers on surfaces. About 760 smokers and their non-smoking family members will take part. The program combines quitting support with educa…

This study tests whether giving cancer patients personalized recommendations to quit smoking—based on their genes, health history, and lab results—helps them stop more than standard care. About 112 patients and their doctors will take part. The goal is to see if this tailored app…

This study tests a counseling and education program designed specifically for Chinese and Korean American smokers who are at high risk for lung cancer. The program aims to help participants quit smoking and get screened for lung cancer. Researchers will measure how many people su…

This study tests a program that helps African American smokers quit smoking and get screened for lung cancer. About 250 people will take part. The goal is to reduce lung cancer deaths in this group.

This study tests a program to help smoking parents quit by combining brief advice, nicotine replacement therapy (like patches or gum), and mobile messaging support. The goal is to help parents stop smoking and reduce their children's exposure to secondhand smoke. About 1,200 dail…

This study tests a text-message program called Quitxt to help young Latino adults (ages 18-29) quit smoking. About 1,200 participants will be randomly assigned to receive either Quitxt or standard quit-smoking texts. Researchers will check if they've quit at 1, 3, and 6 months us…

This study tests whether a pharmacist-delivered coaching program called QuitAid helps rural smokers in Appalachia quit. About 768 participants will receive nicotine patches and may also get text support, phone counseling, or extra nicotine gum. The goal is to find the best combin…

This study tests a smartphone app designed to help pregnant women stop smoking and stay smoke-free after giving birth. The app uses artificial intelligence to personalize tips and includes a support person chosen by the participant. About 790 pregnant smokers in Romania will be r…

This study tests whether offering financial rewards to both a smoker and a family member can help Alaska Native and American Indian adults quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive or standard support. Success will be m…

This study compares two smoking cessation programs for 1,188 people who are getting lung cancer screening. Participants must be current smokers aged 50-80 with a heavy smoking history. The goal is to see which program helps more people quit smoking for good, using both self-repor…

This study tests an online questionnaire (e-visit) that helps smokers in rural areas quit. About 288 adults who smoke daily will be randomly assigned to get the e-visit or not. The e-visit asks about smoking habits and preferences for quit-smoking medications, and may lead to a p…

This study tests a smoking cessation program in the construction industry, where safety managers are trained to help workers quit smoking. About 608 construction workers and their managers will participate. The goal is to find the most effective and cost-efficient way to reduce s…

This study tests a smoking cessation program designed specifically for people living with HIV. The goal is to help 500 participants quit smoking using a cost-effective approach that is easy to scale. The program includes nicotine replacement therapy and support, with success meas…

This study tests whether automated, personalized text messages can help 800 smokers living with HIV in Cambodia quit smoking. Participants will receive tailored messages and set a quit date within two weeks. Researchers will check progress using self-reports and carbon monoxide b…

This study is testing a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults who smoke and are preparing for weight-loss surgery lose weight and quit smoking. About 20 participants will try the program to see if it is feasible and accepta…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people stop smoking cigarettes. Fifty adult smokers will use the pouches for 4 weeks instead of smoking. Researchers will track how many people fully switch and how much their smoking drops. The goal is…

This study tests whether taking the smoking cessation drug bupropion for 6 months helps African American daily smokers quit more successfully than the standard 7-week treatment. About 500 participants will be followed for 6 months to see who stays smoke-free. The goal is to find …

This study compares two different smartphone apps designed to help people living with HIV quit smoking. All participants will also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free over 6 months.

This study tests whether giving smokers a personalized treatment plan—based on their genes, health history, and other markers—helps them quit better than standard care. About 850 adult smokers from primary care clinics will take part. The goal is to see if this tailored approach …

This study tests whether helping both patients and their household members quit smoking together works better than helping patients alone. About 231 patients who smoke and live with other smokers will join a program that offers nicotine replacement therapy and support. Researcher…

This study is testing whether routine urine tests every 6 months for 2 years can find bladder cancer at an earlier stage in people at high risk. Participants must be 50 or older with a heavy smoking history or long-term exposure to certain workplace chemicals. The goal is to see …

This study looks at whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have r…

This study looks at whether adding low-dose CT scans for lung cancer to smoking cessation programs helps more people quit smoking. About 1,200 smokers aged 50-74 who smoke heavily will be split into groups to compare different methods. The goal is to see if the combination leads …

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke will get either standard quit-smoking support or extra reminders and encouragement. The goal is to see which approach gets more people to use quit-smoking tools like…

This study tests whether adding music therapy to nicotine patches helps student smokers (ages 18-25) reduce cravings more than patches alone. 120 participants will be randomly assigned to either music therapy plus patches or patches only. The goal is to see if a digital music too…

This study tests whether nicotine pouches or nicotine mini lozenges help people smoke fewer cigarettes. About 300 adult smokers will use one of these products or no product for a week, then try to stop smoking for 3 weeks. Researchers will track how many cigarettes they smoke and…

This study tests a telehealth program for cancer survivors who smoke, are overweight, or don't get enough exercise. About 1,500 people will either get support through telehealth sessions or just receive information. The goal is to see if the program helps them make lasting health…

This study tests a digital coach, called a chatbot, that uses motivational interviewing to help people quit smoking. The chatbot provides education, builds motivation, and creates a personalized quit plan. 440 adult smokers will use the chatbot and be followed for 6 months to see…

This study is developing a new quit-smoking treatment for people who have been diagnosed with cancer. Participants will use a smartphone app that teaches mindfulness techniques to help them stop smoking. The study will enroll 50 adults who smoke at least one cigarette a day and a…

This study aims to find the most effective method for helping people who both smoke cigarettes and use e-cigarettes (vape) quit smoking. Researchers will enroll 500 participants and follow them for 12 months, testing different combinations of treatments like varenicline and nicot…

This study looks at whether a type of talk therapy called acceptance and commitment therapy (ACT) can help people with schizophrenia stop smoking and ease their psychotic symptoms. About 90 adults with schizophrenia who smoke will take part. Researchers will use brain scans (fMRI…

This study tests a smoking cessation program for low-income pregnant women. It combines text message support with financial rewards to see if it helps them quit. The study will compare this approach to text messages alone and measure how well it works and if participants find it …

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines existing methods to support smoking cessation and improve HIV/TB treatment outcomes. Researchers will enroll 86 da…

This study looks at whether cytisinicline, a drug used to help people quit smoking, can change how the brain responds to seeing smoking-related images. 64 daily smokers who are not trying to quit will take either the drug or a placebo and have their brain activity measured with a…

This study is for Veterans who smoke cigarettes and a support person they choose, like a family member or friend. The goal is to see if having that support person helps Veterans use proven quitting methods, such as medication or counseling. Researchers will track how much support…

This study aims to help Alaska Native and American Indian people quit smoking by tailoring their treatment based on how fast their body breaks down nicotine. About 50 participants will receive a personalized medication plan and be followed for 6 months. The goal is to see if this…

This study tests whether a non-invasive brain stimulation technique called rTMS can help people with schizophrenia spectrum disorder quit smoking. Fifty participants will receive active stimulation using one of two coil types, and researchers will track changes in smoking habits …

This study tests a new way to help rural smokers who are not yet ready to quit. Paramedics will refer participants to a text-message program that encourages them to stop smoking. The goal is to see if this approach gets more people to engage and eventually quit.

This study aims to create a smoking cessation program for pregnant women who have experienced trauma. Researchers will interview healthcare workers and pregnant women to understand their needs. The goal is to combine trauma-informed care with standard smoking cessation advice. Th…

This study tests a program called CONNECTing to LungCare that helps smokers and their doctors have better conversations about quitting smoking and getting screened for lung cancer. The program gives patients information and a summary to share with their doctor. The study will see…

This study is creating a mobile health (mHealth) tool to help cancer patients stop smoking. Researchers will test if the tool is easy to use and acceptable to patients. About 90 adult cancer patients who smoke will participate. The goal is to build a resource that can be used by …

This study looks at whether a simple indoor air quality monitor can help cancer patients who smoke keep their homes smoke-free. Ten patients from Memorial Sloan Kettering's Tobacco Treatment Program will use the device for two weeks and attend workshops. The goal is to see if thi…

This study works with community leaders and adults who smoke to find out what makes quitting harder and to design a better support program. Researchers will test a new smoking cessation treatment in a small group of 24 people to see if it is practical and well-liked. The goal is …

This study looks at how romantic partners who both smoke can help each other quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while trying to quit. The goal is to learn which types of support work best so future programs can help couples quit togethe…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and understand the genetic changes that lead to lung disease. Participants must be 18 or…