Brain scans reveal how therapy may help schizophrenia patients kick the habit

NCT ID NCT07441928

Recruiting now Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to cravings. The trial involves 90 participants who will attend group therapy sessions over several weeks, with follow-up at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Acceptance and Commitment Therapy (ACT)
What this could lead to: If it works, this could offer a new way to help people with schizophrenia quit smoking and ease their psychotic symptoms.
What could go wrong: This is an early study with only 90 participants, so results may not apply to everyone. Previous research showed only modest quit rates, and the therapy may not work for all.

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Conditions

The condition(s) this trial relates to.

nicotine dependence schizophrenia Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHENIA DISORDER SMOKING CESSATION

Contacts and locations

Locations

Lok Hong Integrated Community Centre for Mental Wellness, Tung Wah Group of Hospitals
RECRUITING

Hong Kong, Hong Kong
Mental Health and Development, Christian Family Service Centre
RECRUITING

Hong Kong, Hong Kong
Out-patient Clinic (Psy), Pamela Youde Nethersole Eastern Hospital
RECRUITING

Hong Kong, Hong Kong
The Mental Health Association of Hong Kong
RECRUITING

Hong Kong, Hong Kong
The Society of Rehabilitation and Crime Prevention
RECRUITING

Hong Kong, Hong Kong

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