Schizophrenia

This study tests a new drug called Ulotaront (SEP-363856) to see if it can reduce symptoms like hallucinations and delusions in people with schizophrenia. About 522 adults experiencing an acute episode will receive either the drug or a placebo for 6 weeks. The main goal is to mea…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This phase 3 study tests whether KarXT, a new drug, can safely reduce schizophrenia symptoms in 250 Japanese adults experiencing acute psychosis. Participants first receive either KarXT or a placebo for 5 weeks, then all may receive KarXT for a year. The goal is to see if KarXT i…

This early-stage study is testing a single injection of a long-acting form of the drug brexpiprazole in healthy volunteers and people with schizophrenia. The main goal is to check if the injection is safe and tolerable, and how the body processes the drug. The trial involves 56 p…

This study tests whether deep brain stimulation (DBS) can help people with schizophrenia whose symptoms haven't improved with medication. First, doctors map the brain using electrodes to find the problem areas. Then, they implant a device that delivers mild electrical pulses to t…

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up…

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This study is tracking 300 adults with schizophrenia in the U.S. who are prescribed a new drug called xanomeline and trospium chloride (X/T). Researchers want to know if patients prefer this drug over their previous treatment and how satisfied they are with it. The study will als…

This study tracks 1,500 adults with schizophrenia who start taking KarXT (xanomeline and trospium chloride) in routine clinical care across the U.S. Researchers will monitor how doctors adjust doses, side effects, weight changes, and relapses over time. The goal is to understand …

This study tests whether adding sodium benzoate—a substance that affects brain glutamate—to standard antipsychotic medication can improve symptoms and thinking in people with treatment-resistant schizophrenia. About 90 adults who have not responded well to at least two antipsycho…

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This early-stage study is testing a long-acting injectable form of the drug KarXT in 116 people with schizophrenia. The main goal is to check the drug's safety and how the body processes it. Researchers hope this injectable version could offer a more convenient treatment option t…

This study is for people aged 18-35 experiencing their first episode of psychosis. Researchers will use genetic tests and MRI brain scans to see if certain markers can predict which antipsychotic drug (aripiprazole, risperidone, or clozapine) will work best. The goal is to improv…

This pilot study is testing a brain implant called deep brain stimulation (DBS) for people with schizophrenia that hasn't improved with standard treatments. The device delivers electrical pulses to specific brain areas to try to reduce psychotic symptoms. Ten participants will be…

This early-stage trial tests whether the experimental drug aticaprant is safe and tolerable when added to standard antipsychotic treatment for schizophrenia. About 64 clinically stable outpatients will receive either aticaprant or a placebo. The main goals are to see if the study…

This study will enroll 1,000 adults with both opioid use disorder and a mental health condition. Participants will receive standard medication for opioid use disorder, with some also getting a team-based support program called MISSION. The goal is to see if MISSION helps people s…

This Phase 3 trial tests whether the experimental drug NBI-1117568 can delay relapse of schizophrenia symptoms compared to a placebo. About 560 adults with stable schizophrenia will first receive the drug openly, then be randomly assigned to continue it or switch to placebo. The …

This phase 3 trial is testing the long-term safety of the drug NBI-1117568 in 600 adults with schizophrenia. Participants will receive the drug and be monitored for side effects over time. The study is open-label, meaning everyone knows they are getting the drug, and it focuses o…

This study tests whether a combination drug called OLZ/SAM (olanzapine plus samidorphan) causes less weight gain than olanzapine alone in teenagers with schizophrenia or bipolar I disorder. About 220 teens aged 10-17 will take either the combo or olanzapine for 52 weeks. The main…

This study tests whether the diabetes drug metformin can prevent blood sugar increases caused by statins in people with schizophrenia. Researchers will give 400 patients either metformin or a placebo alongside atorvastatin for six months. The goal is to see if metformin helps kee…

This study is testing how the drug KarXT affects bladder function and overall safety in 60 adults with schizophrenia over 12 months. Participants will stop their current antipsychotics and take KarXT to see if it causes any urinary problems. The goal is to ensure the drug is safe…

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests a new drug called NBI-1117570 in 120 adults with schizophrenia who need hospital care. The goal is to see if it improves symptoms like hallucinations and disorganized thinking better than a placebo. Participants take the drug or a placebo daily for 35 days, and r…

This study tests whether adding lumateperone (Caplyta) to clozapine can reduce common side effects like weight gain and high blood sugar in people with schizophrenia or schizoaffective disorder. Fifty participants will take either lumateperone or a placebo for 12 weeks while cont…

This Phase 3 trial tests whether a new drug called NBI-1117568 can improve schizophrenia symptoms like hallucinations and disorganized thinking. About 284 adults with schizophrenia who need hospital care will receive either the drug or a placebo for 5 weeks. The study measures sy…

This study tests a smartphone app that uses motion-sensing cognitive games and interactive stories to help people with schizophrenia improve their thinking, mood, and daily skills. 84 hospitalized adults will be randomly assigned to use the app or receive standard care. The goal …

This study compares clozapine and risperidone in people with schizophrenia, schizoaffective disorder, or bipolar I disorder with psychosis. Researchers want to see if a specific brain biotype (Biotype-1) responds better to clozapine. About 320 participants will be randomly assign…

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study is testing whether clozapine, a medication for schizophrenia, can reduce violent acts better than other antipsychotic drugs. Researchers will enroll 280 people with schizophrenia or schizoaffective disorder who have been violent in the past six months. Participants wil…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This study tests a new drug, LB 102, to see if it helps reduce schizophrenia symptoms better than a placebo. About 456 adults with acute schizophrenia will take either the drug or a placebo for 6 weeks while staying in the hospital. The main goal is to measure changes in symptoms…

This study tests a long-acting injection of cariprazine given once a month, instead of daily pills, for people with schizophrenia, bipolar I disorder, or major depression. The trial involves 24 clinically stable adults and will check safety, side effects, and how well the drug wo…

This early-stage study tests a new drug called VV119 in healthy adults and people with schizophrenia. The main goal is to check if the drug is safe and how the body processes it. About 40 participants will take multiple doses to find the right amount for future studies.

This study tests a gamified mobile health app designed to reduce suicide risk in adults with mental disorders after they leave the hospital. Researchers will enroll 640 participants in Shenzhen, China, and use game-like features to encourage treatment adherence and follow-up visi…

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This study looks at whether taking antipsychotic medication every other day is as effective as taking it daily for people with schizophrenia. 120 participants will be randomly assigned to either daily dosing or every-other-day dosing for one year. The goal is to see if extended d…

This study is testing whether a daily synbiotic supplement (a mix of probiotics and prebiotics) can reduce symptoms of schizophrenia when taken alongside standard antipsychotic medications. Researchers are enrolling 68 adults with schizophrenia or schizoaffective disorder who hav…

This study tests whether ocrelizumab, a drug that suppresses certain immune cells, can reduce psychosis symptoms in people whose schizophrenia or bipolar disorder may be caused by auto-antibodies attacking brain receptors. Forty participants aged 18–35 will receive either ocreliz…

This study tests whether a new generic version of a 3-month schizophrenia injection works the same as the brand-name drug Invega Trinza. About 260 Chinese adults with stable schizophrenia will receive multiple doses of either the test or reference drug. The goal is to see if the …

This study tests whether adding an anti-inflammatory drug to an NMDA-enhancing agent can improve thinking and memory in people with ultra-resistant schizophrenia. About 80 adults who have not responded well to clozapine will receive the combination or a placebo. The goal is to se…

This study looks at the long-term safety of an investigational drug called KarXT when added to current antipsychotic medications for people with schizophrenia. About 280 adults who completed a previous KarXT study will take the drug for up to 52 weeks. Researchers will track side…

This study tests whether a prebiotic supplement (Prebiotin®) can reduce inflammation and improve thinking in people with schizophrenia or schizoaffective disorder. Sixty adults aged 18-60 who are stable on antipsychotics will take the prebiotic or a placebo for 12 weeks. Research…

This study tests whether adding five extra services—like peer support, digital outreach, and group therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants will either receive standard care or the enhanced program. Researchers wi…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can help people with both schizophrenia and alcohol use disorder drink less. Researchers will give weekly injections of tirzepatide or a placebo to 108 participants for 16 weeks, tracking heavy drinking d…

This study looks at whether stopping unnecessary anticholinergic drugs (benztropine or trihexyphenidyl) can improve thinking, quality of life, and brain function in people aged 40-70 with schizophrenia or schizoaffective disorder. Participants will either stay on their medication…

This Phase 2 study tests an investigational drug called emraclidine in about 268 adults with schizophrenia. The trial has two parts: Part A looks at how the drug moves through the body and its safety at different doses, while Part B measures whether it improves symptoms like hall…

This study tests whether adding empagliflozin, a diabetes drug, can reduce weight gain and other metabolic side effects caused by olanzapine in people with schizophrenia. Forty adults aged 18 to 60 who take olanzapine will receive either empagliflozin or a placebo for several wee…

This study compares Magnetic Seizure Therapy (MST) to standard Electroconvulsive Therapy (ECT) in 80 people with treatment-resistant schizophrenia or schizoaffective disorder. MST uses magnetic pulses to trigger a controlled seizure, aiming to ease symptoms like hallucinations an…

This study looks at whether maintenance electroconvulsive therapy (ECT) can prevent relapse in people with schizophrenia that doesn't respond to the strongest medications. About 140 participants who improved after a course of ECT will either continue with maintenance ECT or recei…

This study tests whether giving stronger medications earlier can help people with schizophrenia, major depression, or bipolar depression who did not get better with their first treatment. Over 1,200 participants will receive either standard second-line treatment or an intensified…

This phase 3 trial is testing the long-term safety of a daily pill called SEP-363856 for adults with schizophrenia. Researchers will monitor 100 Japanese participants for side effects over 52 weeks. The goal is to see if this drug can be a safe option for ongoing disease control.

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study tests whether a long-acting injection of iloperidone can delay or prevent the return of schizophrenia symptoms compared to a placebo injection. About 400 adults with schizophrenia who need ongoing treatment will receive either the drug or a placebo and be monitored for…

This study tests a special clinic designed to help people with severe mental illness (like schizophrenia or bipolar disorder) lose weight and improve their metabolic health. About 84 participants will either receive care at this clinic or standard care for 12 months. The main goa…

This study tests a program called Taking Action, where trained peers help college students with serious mental illnesses like depression, bipolar disorder, or schizophrenia learn to manage their condition. About 300 students will be randomly assigned to either the program or just…

This study tests a program called LAGOM designed to improve heart health and quality of life for people with psychotic disorders. 644 adults from six clinics in Gothenburg will either receive the LAGOM program or standard care. The program includes regular check-ups, motivational…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This study tests a new treatment called magnetic seizure therapy (MST) for people with psychotic disorders like schizophrenia. MST uses magnetic pulses to trigger a controlled seizure in the brain, aiming to improve symptoms when added to standard antipsychotic medications. The t…

This Phase 1 trial tests the safety and tolerability of a new extended-release tablet called LY03020 in 40 Chinese adults, including healthy volunteers and people with stable schizophrenia. The drug is also being explored for psychosis related to Alzheimer's disease. Participants…

This study tests whether cariprazine, a daily medication, can safely reduce schizophrenia symptoms in teenagers aged 13 to 17. About 330 participants will receive either cariprazine or a placebo for 6 weeks. The main goal is to see if symptoms improve compared to a placebo.

This study tests whether a six-month program of dietary counseling and group exercise can reduce heart disease risk in adults with severe mental illnesses like schizophrenia or bipolar disorder. Around 70 participants will either receive the lifestyle program plus usual care, or …

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial dysfunction. Researchers will give 50 participants either MitoQ or a placebo daily for 12 weeks, alongside their usual med…

This study looks at whether giving a more powerful medication sooner can help people with schizophrenia who did not get better on their first treatment. About 418 adults will either receive the usual second-line treatment or an early intensified approach. The goal is to see if th…

This study tests different ways to start taking olanzapine, a common schizophrenia medication, to see if a slower dose increase can reduce side effects while still controlling symptoms. About 120 adults with schizophrenia will receive one of several dosing schedules or a placebo.…

This study tests if a daily probiotic powder can prevent or reduce weight gain, high blood sugar, and high cholesterol caused by certain antipsychotic drugs. About 112 adults starting or recently starting olanzapine, quetiapine, risperidone, or clozapine will take either the prob…

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This study tests an experimental oral drug called GXV813 in 142 hospitalized adults with schizophrenia. The goal is to see if it safely reduces symptoms like hallucinations and withdrawal during an acute episode. Participants are randomly assigned to receive GXV813 or a placebo, …

This study tests a new medicine called KYN-5356 to see if it can help with thinking and memory problems in people with schizophrenia. About 150 adults who are stable on their current schizophrenia treatment will take either a low, medium, or high dose of the drug or a placebo for…

This study tests a new drug called roluperidone for treating negative symptoms of schizophrenia, like lack of motivation and social withdrawal. About 380 adults with schizophrenia will take the drug or a placebo for 12 weeks to see if symptoms improve. Then, for 40 more weeks, re…

This study tests whether training mental health professionals to deliver a short psychoeducational program (BREF) can reduce the burden on caregivers of people with schizophrenia or first psychotic episode. The trial will include 206 caregivers, comparing those who receive the pr…

This study tests whether a virtual reality mindfulness app can help people with schizophrenia or schizoaffective disorder control impulsive aggression. About 58 participants will use the VR app or do distraction tasks, and have their brain activity measured with fMRI. The goal is…

This study tests a program called SKILLS that focuses on common factors across different mental health conditions, rather than treating each disorder separately. About 60 adults with stable psychiatric diagnoses will take part. The goal is to see if this approach reduces symptoms…

This study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…

This study tests an experimental drug called evenamide for people with schizophrenia that hasn't improved with standard antipsychotics. About 400 adults will receive either evenamide or a placebo added to their current medication for 12 weeks. The goal is to see if evenamide redu…

This study tests whether infliximab, an anti-inflammatory drug used for arthritis, can improve motivation and brain activity in people with schizophrenia who have high inflammation. Sixty adults with schizophrenia will receive either infliximab or a placebo, and researchers will …

This study tests whether low-intensity ultrasound, aimed at the brain, is safe and could help with schizophrenia symptoms. Eighty adults with schizophrenia will receive the non-invasive treatment. Researchers will check safety and look for any improvements in mood, thinking, and …

This study tests whether bazedoxifene, a drug that mimics estrogen, can help reduce schizophrenia symptoms in women when added to their usual antipsychotic medication. 160 women aged 18-65 with schizophrenia or related disorders will receive either bazedoxifene or a placebo daily…

This study tests whether people with schizophrenia who hear voices that medication doesn't help can learn to quiet them using a special brain-training technique. Participants get real-time feedback from an fMRI scanner to help them shift their brain activity away from the halluci…

This study tests whether learning music—rhythm, singing, and body movements—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based training is a more engaging and effective way …

This study tests whether playing specially designed somatosensory video games for 2 months can improve thinking skills in people with schizophrenia. The games train five cognitive functions like memory and attention using body movements. Researchers will enroll 84 stable patients…

This study tests a 6-week group therapy program for adults with schizophrenia or related disorders. The therapy focuses on changing negative core beliefs (like feeling worthless or that others are dangerous) using compassion-focused techniques. The goal is to see if this approach…

This study tests a new type of transcranial magnetic stimulation (TMS) that targets three brain areas at once to help with negative symptoms of schizophrenia, like lack of motivation, emotion, or social interest. Researchers will enroll 64 people with first-episode schizophrenia …

This study tests whether a low dose of buprenorphine (0.15 mg) can improve social motivation in 40 people with schizophrenia. Participants will take either the drug or a placebo and complete tasks that measure their drive to seek or avoid social interaction. The goal is to see if…

This study tests whether a 24-week supervised exercise program (aerobic, strength, and flexibility) can improve physical fitness, mood, and quality of life in 44 adults with psychosis who are on long-acting injectable medication. Participants are randomly assigned to either the e…

This study tests whether adding a trauma-focused therapy called EMDR to usual care can help reduce trauma symptoms in people with schizophrenia spectrum disorders. Many people with these conditions have experienced trauma, which can make their illness worse, but trauma treatment …

This study tests a virtual reality program designed to help people with psychosis improve their thinking and social skills. The program was created with input from patients and doctors. Researchers will see if it is practical and helpful for daily life. The study involves 52 adul…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This early-stage trial tests BXCL501, a dissolving film placed under the tongue, to quickly reduce agitation in children and teens aged 10-17 with schizophrenia or bipolar disorder. About 140 participants will receive either the drug or a placebo. The study measures changes in ag…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce apathy in people with dementia or mild cognitive impairment. Ten participants will receive rTMS, some also taking the medication methyl…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study tests whether acetazolamide, a drug currently used for altitude sickness and glaucoma, can reduce positive symptoms (like hallucinations or delusions) in people with treatment-resistant schizophrenia. Sixty adults aged 18-55 who still have significant symptoms despite …

This study is testing whether a virtual reality version of a therapy exercise is practical and helpful for adults (ages 18-65) with psychiatric disorders. Participants will try one VR session and answer questions about their experience. The goal is to see if this approach is acce…

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study tests a drug that boosts NMDA activity as a standalone treatment for schizophrenia. It is for people who refuse or cannot tolerate standard antipsychotics. The trial will measure changes in symptoms like hallucinations and social withdrawal in 80 participants over seve…

This study tests whether adding a second drug that boosts NMDA receptors to a sigma-1 receptor agonist can better reduce schizophrenia symptoms than the sigma-1 drug alone. About 90 adults with schizophrenia who did not improve on at least two antipsychotics will take the combina…

This study tests if a non-invasive brain stimulation technique called rTMS can improve negative symptoms (like lack of motivation or emotion) in people with schizophrenia. About 20 adults will receive either real or sham stimulation to different brain areas. The main goal is to s…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study tests whether cromoglicate, a nasal spray used for allergies, can improve symptoms in people with schizophrenia or schizoaffective disorder. Researchers will give 160 adults either the active spray or a placebo, in addition to their usual medication. The goal is to see…

This early-stage trial is testing whether the drug MDMA (commonly known as ecstasy) is safe and tolerable for people with schizophrenia. The goal is to see if it can help with social withdrawal, a common and hard-to-treat symptom. Twenty stable participants will receive three dif…

This study explores whether a yoga-based group program is practical and helpful for outpatients with schizophrenia. Sixty participants will be randomly assigned to yoga, strength training, or standard care. Researchers will measure stress, symptoms, and well-being over 12 weeks a…

This study tests an experimental drug, NBI-1117568, to see if it improves schizophrenia symptoms like hallucinations and delusions better than a placebo. About 284 adults with schizophrenia who need hospital care will take the drug or a placebo for 5 weeks. The main goal is to me…

This study tests whether a non-invasive brain stimulation technique called high-frequency transcranial alternating current stimulation (Hi-tACS) can improve cognitive problems like memory and attention in people with schizophrenia. One hundred participants will receive either rea…

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. Sixty participants will either use the app plus their usual treatment, or just usual treatment alone, for 12 weeks. Researchers will mea…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study tests a new virtual reality job training program for people with schizophrenia who want to work. About 40 adults aged 20 to 55 will practice job interviews and other skills in a safe VR environment. The goal is to see if this training helps improve symptoms and makes i…

This study tests a smartphone app called mSITE that encourages people with schizophrenia or schizoaffective disorder to have more social interactions. Researchers will track participants' social activity and symptoms over time. The goal is to see if the app helps reduce social wi…

This study tests a quick, 5-day brain stimulation treatment for the 'negative symptoms' of schizophrenia, like low motivation and social withdrawal. 75 adults with stable schizophrenia will get either real or fake (placebo) stimulation. The goal is to see if this approach is safe…

This study tests whether breathing extra oxygen (normobaric oxygen therapy) can improve thinking, quality of life, and daily function in people who have had psychosis for less than 5 years. Twenty participants aged 15-35 will be randomly assigned to receive oxygen or a placebo. T…

This study looks at how well and how safely a new sleep medication, lemborexant, works for people who have both a mental health condition and trouble sleeping. About 121 adults will take the drug for 8 weeks, and researchers will track changes in their sleep quality and any side …

This study looks at whether watching Netflix or Disney shows in a small group for 90 minutes each week, over 6 weeks, can improve emotional awareness and reduce anxiety and depression. About 70 adults who have been in mental health treatment for at least 6 months will take part. …

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure brain activity before and after stimulation. The goal is to see if iTBS can …

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and pain severity after …

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to improve thinking skills and daily functioning by using EEG brain scans to identify who will benefit most. A…

This study tests whether clay therapy can improve daily function and social performance in people with schizophrenia who are already on medication. Seventeen participants will take part in clay sessions, and researchers will measure changes in their ability to handle daily tasks …

This study tests a community-based cognitive remediation program for adults with schizophrenia or schizoaffective disorder. Participants do computer exercises and group sessions to improve memory, problem-solving, and social skills. The goal is to see if this helps them function …

This study tests SloMo, a digital therapy that helps people with psychosis who fear harm from others. It combines face-to-face sessions with a mobile app to help users notice worries and slow down fast thinking. 150 participants across three NHS trusts will try the therapy, with …

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce depression in people with schizophrenia. About 180 adults will receive rTMS to the left prefrontal cortex. Researchers will measure changes in mood, thinking, and other symptoms over time.

This study tests a program called 'Need to Be Needed' (N2BN) that uses volunteering to help adults with serious mental illness feel more connected and less lonely. 120 participants will either join the volunteering program or receive weekly listening support. Researchers will mea…

This study tests whether sailing can help people with psychiatric disorders feel better. Forty adults in France will either take sailing lessons or continue their usual care. Researchers will measure changes in quality of life, mental well-being, and self-esteem to see if sailing…

This study tests whether a type of talk therapy focused on sleep (CBT-I) can improve sleep, reduce psychotic symptoms, and enhance quality of life in people with treatment-resistant schizophrenia. About 60 adults with chronic psychosis and long-term sleep problems will receive ei…

This early-stage study tests an experimental oral drug called NTX-253 in healthy volunteers and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. 73 adults aged 18–55 will take single or multiple doses to find the right dose r…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This phase 3 trial tests whether adding cannabidiol (CBD) to standard treatment can improve symptoms, thinking, and inflammation in people with early psychosis. About 120 adolescents and adults will receive either CBD or a placebo for 8 weeks. Researchers will also explore what f…

This study tests a 12-session group program called 'Better Together' for young adults with severe mental illness (like schizophrenia, bipolar disorder, or major depression) who are single and want to improve their romantic relationships. The program teaches communication, emotion…

This study tests whether a personalized form of brain stimulation called iTBS can help reduce schizophrenia symptoms in everyday clinic settings. Forty adults with schizophrenia will receive daily iTBS sessions for two weeks, while continuing their usual medications. Researchers …

This study tests whether brief high-intensity exercise is better than standard high-intensity training for people with schizophrenia or bipolar disorder. Fifty participants will follow one of the two programs for 26 weeks. The main goal is to see which program people stick with l…

This study tests whether a skin patch called ALTO-101 can improve cognitive function in people with schizophrenia who have thinking problems. About 82 participants will receive either the active patch or a placebo, then switch after a period. The main goal is to see changes in br…

This study tests whether a brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help ease depression in people with schizophrenia. Researchers will give up to 20 sessions of active or sham rTMS to 120 participants and use brain scans to see h…

This study tests if a liquid medicine called midazolam can help elderly patients with moderate to severe memory problems who refuse care. About 30 hospitalized patients will receive the medicine before care to see if it reduces their resistance. The goal is to make necessary care…

This study is testing a mobile app that uses cognitive behavioral therapy (CBT) to help people with depression. Over 8 weeks, participants use the app for weekly AI-guided lessons and homework. The goal is to see if the app reduces depression symptoms and to explore how it affect…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This pilot study tests a new type of talking therapy designed for people with early psychosis who experience 'self-disorders' — a feeling of being disconnected from themselves. Eight adults with schizophrenia or psychosis risk will receive the therapy and then be interviewed abou…

This study tests whether a precise magnetic pulse to a specific brain area can improve negative symptoms like apathy and social withdrawal in people with schizophrenia. Forty participants will receive either real or sham stimulation daily for 10 days. Researchers will measure sym…

This study tests whether an oxytocin nasal spray, given before mindfulness-based group therapy, can reduce negative symptoms in people with schizophrenia. Negative symptoms include lack of motivation, social withdrawal, and reduced emotional expression. The trial will compare two…

This study tests whether physical activity in green outdoor spaces reduces negative symptoms (like lack of motivation or social withdrawal) in people with schizophrenia more than indoor exercise. 45 adults aged 18-55 with persistent negative symptoms will participate. Researchers…

This study tests a new psychological program called 'Feeling Safe' for people with psychosis who have persistent delusions. The program offers personalized modules to improve sleep, reduce worry, boost self-confidence, lessen the impact of voices, and build a sense of safety. Res…

This pilot study is testing a new approach called MI-CBTech that combines in-person counseling with a mobile phone app to help homeless veterans who have serious mental illnesses like schizophrenia. The goal is to help them set and achieve personal goals for community integration…

This study tests a 12-week group therapy program called Motivation Skills Training for people with schizophrenia or schizoaffective disorder. The goal is to see if it improves motivation, goal attainment, and quality of life compared to a control group focused on healthy behavior…

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This pilot study tests whether a non-invasive magnetic brain stimulation technique called TMS can improve brain connectivity and thinking skills in people with schizophrenia. Forty adults will receive either real or sham TMS daily for four weeks, and researchers will measure chan…

This study tests whether real-time fMRI neurofeedback can help people with schizophrenia who still hear voices despite medication. Participants learn to control their own brain activity while inside an MRI scanner, aiming to reduce the brain signals linked to auditory hallucinati…

This study is testing whether an NMDA-enhancing drug can improve negative symptoms of schizophrenia (like lack of motivation or social withdrawal) and if it works better in men or women. 90 people with stable schizophrenia will receive either the drug or a placebo for several wee…

This study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…

This study aims to create a 'patient library' by collecting blood, stool, and hair samples from 250 people aged 15 to 30 who have had a first psychotic episode or are at high risk. Researchers will track their mental health over 10 years using the CAARMS test. The goal is to bett…

This study follows 178 people who had a first episode of psychosis to see how early treatment choices and relapses affect their thinking, daily life, and mental health over 20 years. Participants attend one interview to assess symptoms, thinking skills, and functioning. The goal …

This study compares two ways to help adults with mental health issues get follow-up care. One group gets usual care after an emergency room visit, while the other uses a new system that books a psychiatrist appointment within 48 hours through their general doctor. Researchers wil…

This study aims to create a French-language memory task that can be used during brain scans to measure source-monitoring—the ability to remember where information came from. Researchers will test the task on 120 people, including those with schizophrenia and healthy volunteers. T…

This study looks at whether a tool called the Decision Helper helps people with mental health conditions take a more active role in choosing their treatment. About 62 adults in Danish outpatient mental health clinics will have their consultations recorded and analyzed. The goal i…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at the mental health of 200 teenagers aged 12 to 16 who attend special educational institutes (ITEPs) in France. Researchers will use psychiatric interviews to find out how many have conditions like depression or anxiety. The goal is to better understand their ne…

This study will follow 1,200 people with schizophrenia in Shanghai for up to 5 years. Researchers will track symptoms, aggression, and other mental health changes to understand how the disease progresses. The goal is to build a long-term database and biobank to improve future car…

This study aims to improve suicide prevention for people who move between healthcare and the criminal-legal system. Researchers will link health records, Medicaid data, and jail booking information to identify individuals at risk and coordinate care. Over 1,000 adults with past p…

This study looks at brain activity during sleep in people with early-course schizophrenia compared to healthy individuals. Researchers will play soft tones during deep sleep using a wearable headband to see if it can strengthen sleep-related brain waves and improve memory. The go…

This study is testing whether subtle changes in how people speak can predict who will develop schizophrenia. Researchers will record and analyze free speech from 215 young people aged 15-30 who are at ultra-high risk for psychosis. By using computer programs to detect semantic an…

This study explores whether a non-invasive brain stimulation technique called rTMS can reduce cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will compare brain activity changes in 100 participants, including healthy cannabis users. The goa…

This study tests a program to help doctors in psychiatric clinics prescribe medications for alcohol use disorder to patients who also have serious mental illness. The program uses an external facilitator to work with clinic staff and overcome barriers to prescribing. The goal is …

This study investigates whether abnormal insulin action in the brain contributes to cognitive and metabolic problems in schizophrenia. Twenty participants (some with schizophrenia, some healthy) will receive either intranasal insulin or a placebo before a PET scan that measures b…

This study is collecting blood samples and questionnaires from 1,100 people with bipolar disorder or schizophrenia. Researchers are looking for links between genetics, inflammation, and a dormant virus called HERV-W. The goal is to find new biomarkers and pave the way for future …

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…

This study investigates how the brain chemical glutamate relates to memory and attention in people who have recently experienced psychosis. Researchers will use brain scans and a mild electrical stimulation technique called tDCS to see if glutamate levels can predict who responds…

This study looks at how to measure cardiorespiratory fitness in people with severe mental illness, such as schizophrenia or bipolar disorder. Researchers will compare three different fitness tests in 50 patients and 25 healthy volunteers. The goal is to find a simple, accurate wa…

This study is testing a new, non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) to measure tiny brain movements. Researchers will compare these measurements in 300 people with mild versus major cognitive disorders. The goal is to see if brain pulse patterns…

This study looks at how people with schizophrenia-spectrum disorders update their beliefs after treatment for persecutory delusions. Researchers will use therapy, brain scans, and learning tasks to see if treatment changes how the brain responds to uncertainty. The goal is to bet…

This study uses a special PET scan tracer called [11-C]OMAR to measure cannabinoid receptors in the brain. Researchers will compare healthy volunteers to people with schizophrenia, cannabis dependence, PTSD, opioid use disorder, and other conditions. The goal is to understand how…

This study uses powerful 7T MRI scanners and visual perception tests to find biological markers for severe mental disorders like major depression, schizophrenia, and bipolar disorder. Researchers will compare brain chemistry and vision in 320 patients and healthy volunteers. The …

This study looks at how being in a hot room affects the body, thinking, and mood of people with schizophrenia. Ten adults with and without schizophrenia will sit in a warm or very hot room for six hours, doing light activity. The goal is to learn how heat impacts them so we can c…

This study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…

This study tests whether a fast form of brain stimulation (accelerated iTBS) can improve thinking and memory in 30 adults with schizophrenia or schizoaffective disorder who are already taking the medication clozapine. Participants will receive both real stimulation and a sham (fa…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study explores whether a gentle electrical current applied to the scalp (tDCS) can improve attention, learning, and memory in people with schizophrenia. Researchers will compare stimulation during a task versus rest, and front versus back of the head. They will also measure …

This study looks at language difficulties in people with psychosis, including those at risk, experiencing a first episode, or diagnosed with schizophrenia. Researchers will give a full language test to 90 patients and compare results with a healthy control group. The goal is to b…

This study investigates how people with schizophrenia experience time and sensory information differently. Researchers will use a visual illusion task to see if small timing disruptions affect perception. The goal is to better understand the link between time processing and psych…

This study looks at how people with schizophrenia sense time through touch. Researchers measure finger movements and brain signals to see if problems with timing can help predict who might develop psychosis. The goal is to find early markers for better care.

This study investigates how the immune system influences psychotic symptoms and response to antipsychotic medication. Researchers will collect blood and spinal fluid from 500 participants, including those starting or changing antipsychotics and healthy controls. The goal is to fi…

This study uses brain imaging (fMRI) to investigate why people with schizophrenia or depression often have trouble with memory and managing emotions. Researchers will scan the brains of 90 adults aged 18-60 while they perform tasks and at rest. The goal is to better understand th…

This study explores whether a non-invasive magnetic brain stimulation technique (TMS) can temporarily improve how quickly people with psychotic disorders (like schizophrenia or bipolar) solve problems. About 95 participants will do thinking tasks and get brain scans before and af…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study looks at how attention and thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to healthy volunteers. Participants will use a positive thinking strategy during a gambling task while having t…

This study uses virtual reality games and EEG brain scans to understand how people with schizophrenia or bipolar disorder experience the passage of time. Researchers will compare 120 participants (patients and healthy volunteers) as they perform tasks in virtual environments. The…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can improve how people with schizophrenia recognize emotions in faces. Researchers will use brain scans to see if the stimulation changes activity in motion-processing areas. The goal is to understan…

This study looks at how brain structure and gene activity in the blood are linked in people with early schizophrenia. About 1,899 participants, including healthy volunteers, will have brain scans and blood tests at the start and after one year of regular medication. The goal is t…

This study looks at how people with schizophrenia experience nicotine withdrawal when they stop vaping or smoking for 24 hours. Researchers will compare withdrawal symptoms, mood, and thinking skills between daily vapers and daily smokers. The goal is to understand nicotine depen…

This study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study uses a non-invasive brain stimulation technique called TMS to see if it can change brain activity in people with schizophrenia. Researchers will measure brain waves before and after stimulation to understand how the hippocampus works in this condition. The goal is not …

This study tests whether learning to play a music video game like Guitar Hero can strengthen the brain's white matter in people with schizophrenia. White matter helps different brain regions communicate quickly, and it is often impaired in schizophrenia, leading to slower thinkin…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at whether social isolation contributes to the early health problems seen in people with schizophrenia, who often die 10–20 years earlier than others. Researchers will follow 650 participants (500 with schizophrenia and 150 siblings) aged 40–70, tracking medical …

This study tests whether diroximel fumarate, a drug already used for multiple sclerosis, can increase levels of the antioxidant glutathione in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the …

This study tests whether a type of brain stimulation called repetitive TMS can increase natural brain inhibition in 34 people with schizophrenia. The goal is to see if this change relates to better thinking and memory. Participants will receive five days of treatment and undergo …

This study uses high-resolution 7-Tesla MRI to examine how a part of the brain called the mediodorsal thalamus supports flexible thinking and decision-making. One hundred healthy adults will perform computer tasks while their brain activity is scanned. The goal is to understand w…

This study tests whether analyzing speech recordings with artificial intelligence can help predict when someone with psychosis might relapse. About 360 participants, including people with psychosis and healthy volunteers, will provide weekly voice samples and answer questions via…

This study looks at whether brain activity synchronizes differently in people with schizophrenia during social interactions. Researchers will compare 100 participants—some with schizophrenia and some without—as they chat and do tasks together while wearing EEG caps. The goal is t…

This study explores the brain basis of social difficulties in 30 teens with autism and 30 with schizophrenia. Participants take part in a 16-week social skills program called PEERS, and undergo brain scans before and after to see how the intervention affects brain networks. A con…

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with psychotic disorders (like schizophrenia) or cannabis use disorder, compared to healthy volunteers. The goal is to understand how brain connection changes relate to …

This study is following 200 children and teens (ages 7-20) who have experienced psychosis to see if they fall into distinct subgroups. Researchers will use interviews, brain scans, and genetic tests to classify participants. The goal is to see if these subgroups predict how well …

This study tests a program called iTEST for people with schizophrenia or related disorders. The program combines daily brain-training exercises on a mobile device with coaching to help participants more accurately judge their own skills. Researchers want to see if this improves h…

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to understand how hallucinations work in people with schizophrenia or schizoaffective disorder. Researchers will stimulate a specific brain circuit and measure changes in brain connectivity and…

This study is looking at 200 people with treatment-resistant schizophrenia who are starting clozapine. Researchers will measure immune markers in blood and spinal fluid, brain scans, and other tests before and after 12 weeks of treatment. The goal is to find biological signs that…

This study looks at 55 women who have a chronic (long-term) infection with the Toxoplasma parasite and also have a mental health condition like schizophrenia, depression, or bipolar disorder. Researchers want to see if tiny molecules called microRNAs in the blood can help tell th…

This study looks at 30 adults with psychotic disorders who are stable on long-term antipsychotics and want to reduce or stop their medication. Researchers will describe real-life cases to understand what works, what doesn't, and the risks of relapse. The goal is to learn practica…

This study is testing a new questionnaire called ESSME that is given to people with schizophrenia at their homes. The goal is to see if this home-based assessment can better capture their real-life needs compared to standard methods. 56 participants will be followed for 6 months …

This study looks at how the brain uses ketones and sugar for energy in people experiencing their first episode of schizophrenia. Researchers will use PET scans to compare brain metabolism in 22 patients before and after 4-8 weeks of antipsychotic treatment, and also compare them …

This study is measuring how well people with schizophrenia or bipolar disorder can exercise, breathe, and manage daily life. Researchers will test lung function, breathing muscle strength, and walking ability in 150 adults. The goal is to find physical limitations that could be i…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study looks at whether a recovery-focused program can help people with severe mental illness living in supported housing. About 72 participants will either receive the new program or standard care. The goal is to see if focusing on personal goals improves daily functioning a…

This study is testing whether MRI brain scans can help predict which patients having their first psychotic episode will not respond to standard treatment. Researchers will scan 80 people aged 18-35 with schizophrenia or related disorders who have never taken antipsychotic medicat…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This pilot study uses MRI scans to investigate whether a small brain area called the inferior colliculi plays a role in auditory hallucinations in people with schizophrenia. Researchers will compare brain activity in 40 participants—20 with hallucinations and 20 without—while the…

This pilot study is testing whether two established trauma therapies—Prolonged Exposure and EMDR—can be safely used in young adults with psychotic disorders who also have PTSD symptoms. Twenty participants from the OPUS early-intervention program will receive one of the therapies…

This study tests a program called PRESTO that aims to identify and treat first-episode psychosis sooner. The program educates the public, trains frontline workers like doctors and teachers, and provides a mobile team to connect patients to care. Researchers will measure whether t…

This study looks at whether teaching families skills to support young adults with psychosis can reduce stress for caregivers and help patients stay stable. About 113 family members will attend 9 weekly classes led by experts. Researchers will measure family burden, patient sympto…

This study looks at how the brain processes visual information in people with schizophrenia, bipolar disorder, or schizoaffective disorder. Researchers will use a non-invasive EEG cap to measure brain waves while participants view simple visual patterns. The goal is to find early…

This study aims to create brain-based tools to identify which veterans with chronic psychosis are most likely to benefit from cognitive rehabilitation. Researchers will use EEG recordings to measure brain activity and see if these signals can predict improvements in thinking skil…

This observational study will collect genetic and health information from 50,000 people with serious mental illnesses like bipolar disorder, schizophrenia, major depression, and dementia. Researchers will link this data to electronic health records to find patterns and risk facto…

This study looks at whether older adults who develop hallucinations or delusions for the first time may have early signs of dementia. Researchers will use special brain scans (tau PET) and blood tests to check for abnormal proteins linked to Alzheimer's. The goal is to better und…

This study is creating a program called START-VET to help veterans with mental illness or substance use disorders who have recently left prison. Researchers will work with 20 veterans to develop transition materials and tools. The goal is to improve quality of life and reduce cri…

This study looks at how common sleep apnea is in people hospitalized with schizophrenia and whether it affects their mental health. Researchers will use a special ring and a fiber-optic mat to track breathing during sleep without any wires or uncomfortable equipment. The goal is …

This observational study follows 300 adults receiving strategic psychotherapy—a short-term, goal-focused talk therapy—in private practice. Participants fill out questionnaires about their symptoms and well-being before and after treatment. The goal is to see if this therapy leads…

This study looks at tiny particles called exosomes in the blood of people experiencing their first episode of schizophrenia. Researchers want to see if the genetic material inside these particles is linked to problems with thinking and memory. By studying 300 participants, they h…

This study looks at whether a gentle brain stimulation technique called tDCS can change the density of synapses (connections between brain cells) in people with schizophrenia. Researchers will use special PET scans to measure these changes in 20 participants. The goal is to under…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like working memory, attention, and decision-making—in people with conditions such as traumatic brain injury, depression, bipolar disorder, schizophrenia, ADHD, bo…

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor…

This study compares brain energy use, lactate, and glutamate levels in 75 people with schizophrenia and healthy volunteers using advanced MRI and PET scans. Researchers aim to see if brain glucose use is lower and lactate higher in schizophrenia, and if glutamate varies more. No …

This study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…