New drug combo tested for long-term safety in teens with schizophrenia and kids with autism

NCT ID NCT07424404

Recruiting now Disease control Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study is checking the long-term safety of a drug called KarXT in teenagers (13-17) with schizophrenia, and a combination of KarXT and KarX-EC in children (5-17) with irritability linked to autism. About 400 participants who completed earlier studies will take the drug for up to 2 years. The main goal is to see what side effects occur, not to measure how well the drug works.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

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Study contacts

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Phone: •••-•••-•••• Email: •••••@•••••
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Locations

Advanced Research Center Inc.
RECRUITING

Anaheim, California, 92805, United States

Contact Phone: •••-•••-••••
Apg Research, Llc
RECRUITING

Orlando, Florida, 32803, United States

Contact Phone: •••-•••-••••
Atlanta Center for Medical Research
RECRUITING

Atlanta, Georgia, 30331, United States

Contact Phone: •••-•••-••••
Cluj Napoca Emergency Hospital for Children, Department of Pediatric Psychiatry
RECRUITING

Cluj-Napoca, 400370, Romania

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Denali Health Atlanta, LLC
RECRUITING

Stone Mountain, Georgia, 30083, United States

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EmVenio Research Center - Prime Healthcare
RECRUITING

Chicago, Illinois, 60622, United States

Contact Phone: •••-•••-••••
Emergency Clinical Hospital For Children Louis Turcanu Timis
RECRUITING

Timișoara, 300329, Romania

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Goryokai Medical Corporation - Goryokai Hospital
RECRUITING

Sapporo, Hokkaido, 002-8029, Japan

Contact Phone: •••-•••-••••
Inland Psychiatric Medical Group.
RECRUITING

Chino, California, 91710, United States

Contact Phone: •••-•••-••••
Local Institution - 0008
NOT_YET_RECRUITING

Iași, 700282, Romania

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Local Institution - 0024
NOT_YET_RECRUITING

Culver City, California, 90230, United States

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Local Institution - 0025
NOT_YET_RECRUITING

Zentsujichó, Kagawa-ken, 765-8507, Japan

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Local Institution - 0029
NOT_YET_RECRUITING

Bucharest, Bucharest, 041914, Romania

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Local Institution - 0035
NOT_YET_RECRUITING

Córdoba, X5003DCE, Argentina

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Local Institution - 0036
WITHDRAWN

Buenos Aires, C1405BOA, Argentina
Local Institution - 0040
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Bucharest, 021056, Romania

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Local Institution - 0042
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Bucharest, 031871, Romania

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Local Institution - 0050
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Richmond, Virginia, 23284, United States

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Local Institution - 0054
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Dothan, Alabama, 36303, United States

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Local Institution - 0056
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Ōta-ku, Tokyo, 143-8541, Japan

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Local Institution - 0059
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Worcester, Massachusetts, 01608, United States

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Local Institution - 0061
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Great Neck, New York, 11021, United States

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Local Institution - 0062
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Miyakonojō, Miyazaki, 885-0093, Japan

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Local Institution - 0063
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Yokohama, Kanagawa, 213-8507, Japan

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Local Institution - 0066
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Spring, Texas, 77381, United States

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Local Institution - 0075
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Chikugo, Fukuoka, 833-0041, Japan

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Local Institution - 0076
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Boston, Massachusetts, 02115, United States

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Local Institution - 0083
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Redlands, California, 92373, United States

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Local Institution - 0084
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1107, Argentina

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Local Institution - 0085
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La Plata, Buenos Aires, 1900, Argentina

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Local Institution - 0086
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Bunkyo-ku, Tokyo, 113-8431, Japan

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Local Institution - 0089
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San Francisco, California, 94158, United States

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Local Institution - 0098
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Madrid, 28007, Spain

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Local Institution - 0099
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Barcelona, 8035, Spain

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Local Institution - 0100
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Madrid, 28031, Spain

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Local Institution - 0101
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Barcelona, 08036, Spain

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Local Institution - 0106
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Brisbane, Queensland, 4101, Australia

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Local Institution - 0107
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Westmead, New South Wales, 2145, Australia

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Local Institution - 0108
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Melbourne, Victoria, 3052, Australia

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Local Institution - 0109
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Melbourne, Victoria, 3168, Australia

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Local Institution - 0110
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Kingston, Ontario, K7L4X3, Canada

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Local Institution - 0111
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Edmonton, Alberta, T6G 1Z1, Canada

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Local Institution - 0112
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Montreal, Quebec, H3T 1C5, Canada

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Local Institution - 0113
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Toronto, Ontario, M4G 1R8, Canada

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Local Institution - 0116
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Santiago del Estero, G4200DND, Argentina

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Local Institution - 0118
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Bordeaux, 33076, France

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Local Institution - 0119
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Paris, 75019, France

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Local Institution - 0120
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Bron, 69678, France

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Local Institution - 0121
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Gdansk, 80-546, Germany

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Local Institution - 0122
NOT_YET_RECRUITING

Kraśnik, Lublin Voivodeship, 23-210, Poland

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Local Institution - 0123
NOT_YET_RECRUITING

Szczecin, West Pomeranian Voivodeship, 70-419, Poland

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Local Institution - 0124
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Katowice, 40-146, Poland

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Local Institution - 0125
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Wroclaw, Lower Silesian Voivodeship, 54-234, Poland

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Local Institution - 0126
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Gdansk, Pomeranian Voivodeship, 80-542, Poland

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Local Institution - 0127
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Warsaw, Masovian Voivodeship, 02-957, Poland

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Local Institution - 0128
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Poznan, Greater Poland Voivodeship, 60-744, Poland

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Local Institution - 0129
NOT_YET_RECRUITING

Budapest, 1143, Hungary

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Local Institution - 0130
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Gyula, 5700, Hungary

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Local Institution - 0131
NOT_YET_RECRUITING

Szeged, 6720, Hungary

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Local Institution - 0132
NOT_YET_RECRUITING

Lexington, Massachusetts, 02421, United States

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Local Institution - 0137
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Nashville, Tennessee, 37212, United States

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Local Institution - 0139
NOT_YET_RECRUITING

West Chester, Ohio, 45069, United States

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Local Institution - 0140
NOT_YET_RECRUITING

Provo, Utah, 84604, United States

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Local Institution - 0141
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Orem, Utah, 84097, United States

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Local Institution - 0142
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Columbia, Missouri, 65201, United States

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Local Institution - 0143
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Danville, Pennsylvania, 17821, United States

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Local Institution - 0144
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Las Vegas, Nevada, 89128, United States

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Local Institution - 0145
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Boca Raton, Florida, 33428, United States

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Local Institution - 0146
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Neptune City, New Jersey, 07753-4859, United States

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Local Institution - 0147
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Lincoln, Nebraska, 68526, United States

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Local Institution - 0148
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Cincinnati, Ohio, 45229, United States

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Local Institution - 0149
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Dallas, Texas, 75243, United States

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Local Institution - 0150
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Pittsburgh, Pennsylvania, 15213-3403, United States

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Local Institution - 0151
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The Bronx, New York, 10461, United States

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Local Institution - 0152
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Bloomfield Hills, Michigan, 48302, United States

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Local Institution - 0153
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States

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Local Institution - 0154
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New Haven, Connecticut, 06520, United States

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Local Institution - 0155
NOT_YET_RECRUITING

Everett, Washington, 98201, United States

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Local Institution - 0156
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Staten Island, New York, 10314, United States

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Local Institution - 0157
NOT_YET_RECRUITING

San Rafael, California, 94903, United States

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Local Institution - 0158
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Orange, California, 92868, United States

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Local Institution - 0159
NOT_YET_RECRUITING

Anaheim, California, 92805, United States

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Local Institution - 0160
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Gainesville, Florida, 32607, United States

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Local Institution - 0161
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Colorado Springs, Colorado, 80910, United States

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Local Institution - 0162
NOT_YET_RECRUITING

Glendale, California, 91203, United States

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Local Institution - 0163
NOT_YET_RECRUITING

Phoenix, Arizona, 85006, United States

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Local Institution - 0164
NOT_YET_RECRUITING

Gainesville, Florida, 32607, United States

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Local Institution - 0165
NOT_YET_RECRUITING

Plano, Texas, 75093, United States

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Local Institution - 0166
NOT_YET_RECRUITING

Orange City, Florida, 32763, United States

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Local Institution - 0167
NOT_YET_RECRUITING

West Point, Utah, 84015, United States

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Local Institution - 0168
NOT_YET_RECRUITING

Hollywood, Florida, 33024, United States

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Local Institution - 0169
NOT_YET_RECRUITING

Houston, Texas, 77043, United States

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Salveo Integrative Health - Lawrenceville
RECRUITING

Lawrenceville, Georgia, 30046, United States

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University of Cincinnati Cancer Institute
RECRUITING

Cincinnati, Ohio, 45219, United States

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VAST Clinical Research
RECRUITING

Garland, Texas, 75043, United States

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